DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DLG1 and pyd

DIOPT Version :9

Sequence 1:NP_004078.2 Gene:DLG1 / 1739 HGNCID:2900 Length:926 Species:Homo sapiens
Sequence 2:NP_001246998.1 Gene:pyd / 41062 FlyBaseID:FBgn0262614 Length:2395 Species:Drosophila melanogaster


Alignment Length:898 Identity:202/898 - (22%)
Similarity:349/898 - (38%) Gaps:284/898 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   203 NTDSLETPT---------YVNGTDADYEYEEITLER-GNSGLGFSIAGGTDNPHIGD-DSSIFIT 256
            |::.|||.:         :..|....:||..:.:.| ...|.|.:::||.||||..: |.||.::
  Fly   220 NSNLLETASTHSSSQRRRFKKGDRTTWEYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVS 284

Human   257 KIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIK 321
            .::.||.|  :.||:|||.|:.||.|.:.:|.::.||:.|:::|:.|:|.||||.|::.      
  Fly   285 DVLKGGPA--EDRLQVNDRIISVNGVSLENVEYATAVQVLRDSGNTVQLVVKRRVPLNP------ 341

Human   322 LIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAA--------------------------- 359
                     .:.||.|.:||....:|:.:.....||.|                           
  Fly   342 ---------INAAGAVQHQHSHSLSSVGLMANGSGGVAPTPITSLSQPNSLNSSLVQNASSGQPI 397

Human   360 ----HKDGK-------------------------------LQIGDKLLAVNN------------- 376
                .|.||                               ||.||.:..::|             
  Fly   398 KVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQEGDIITRIHNTNCGDTMSLKEAK 462

Human   377 ------------VCLEEVTHEEAVTALK-------NTSDFVY------LKVAKPTSMYMNDGYAP 416
                        |.|.::|::.||:.|.       ..|..:|      :.....::..:.|.|.|
  Fly   463 KIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQASGNIYATHQPQVSGCSSSNNNLEDPYLP 527

Human   417 ---------------------PDITNS-----------------------SSQPVDNHVSP---- 433
                                 |:|..:                       |.|.:|..|:|    
  Fly   528 GGASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNLTPRGRSRGPIMDGVSLQQLDRPVTPTRGR 592

Human   434 SSFLGQTPASPAR------------YSPVSKAVLGDDEITREPRKVVLHR-GSTGLGFNIVGGED 485
            |:.:.:.|..|..            ||  |:..|.::..:.|||.:...: ||.|:  .:.||.:
  Fly   593 SAAIDEPPRPPPPRGSSGGAAQEDFYS--SRRQLYEERQSAEPRFISFQKEGSVGI--RLTGGNE 653

Human   486 GEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEY 550
            . |||::.:..|.||.|.| |..||:|:.||.:|:...:.|:|...|.:....:.::.||..|||
  Fly   654 A-GIFVTAVQPGSPASLQG-LMPGDKILKVNDMDMNGVTREEAVLFLLSLQDRIDLIVQYCKEEY 716

Human   551 SRFEAKIHDLREQMMNSSISSGSGSLRTSQK-RSLYVRALFDYDKTKDSGLPSQG-LNFKFGDIL 613
            .                       .:.|:|: .|.:::..|..|.      ||:| :.||.||:.
  Fly   717 D-----------------------EVVTNQRGDSFHIKTHFHCDN------PSKGEMAFKAGDVF 752

Human   614 HVINASDD---EWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGQSFNDKR 675
            .||:...:   ..||..::....:..:.||||:|.|.|:     |.|.:||:..::  .:.|:.|
  Fly   753 RVIDTLHNGVVGSWQVLKIGRGHQEMQRGVIPNKSRAEE-----LATAQFNATKKE--MNANESR 810

Human   676 KKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVI 740
            ......|:....::|..|.:...|.      ..|||.|.:...|..||.:.       .:.|||:
  Fly   811 GNFFRRRRSTHRRSKSLSRENWDDV------VFSDSISKFPAYERVVLRHP-------GFVRPVV 862

Human   741 ILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQ 805
            :.||:.|...:.|..:|||||.:       |.:|.:                         ::..
  Fly   863 LFGPVSDLARERLAKDFPDKFST-------PLQDDD-------------------------KSAA 895

Human   806 YNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRL--- 867
            .:.......:.::|:|.::|||.:||::.||:.||..||.||:.||:|..|...|.::...|   
  Fly   896 TSGKCRIVRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQLRHGLPKA 960

Human   868 TEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWV 920
            ..:.::|..|:..|||:.::..|:..:.....|..|.:::..|:.|....:|:
  Fly   961 AHKSSKKLLEQCQKLERVWSHIFSTQIALSDEESWYRKLRDSIDLQQSGAVWM 1013

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DLG1NP_004078.2 L27_1 2..62 CDD:370268
MAGUK_N_PEST 106..223 CDD:371162 6/28 (21%)
PDZ_signaling 224..308 CDD:238492 31/85 (36%)
PDZ_signaling 317..403 CDD:238492 25/185 (14%)
PDZ_assoc 404..465 CDD:371157 18/120 (15%)
PDZ 463..547 CDD:214570 28/84 (33%)
SH3_DLG1 582..648 CDD:212964 20/69 (29%)
Guanylate_kin 735..913 CDD:366206 44/180 (24%)
pydNP_001246998.1 PDZ_signaling 249..334 CDD:238492 31/86 (36%)
PDZ_signaling 396..477 CDD:238492 9/80 (11%)
PDZ_signaling 633..710 CDD:238492 25/80 (31%)
SH3_ZO 729..790 CDD:212793 19/66 (29%)
GuKc 831..1007 CDD:214504 52/220 (24%)
ZU5 2263..2351 CDD:279170
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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