DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rig-6 and Nrg

DIOPT Version :9

Sequence 1:	NP_001022014.1	Gene:	rig-6 / 173828	WormBaseID:	WBGene00016354	Length:	1196	Species:	Caenorhabditis elegans
Sequence 2:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster

Alignment Length:	1087	Identity:	256/1087 - (23%)
Similarity:	394/1087 - (36%)	Gaps:	237/1087 - (21%)

- Green bases have known domain annotations that are detailed below.

Worm   167 LPCTVQGNPKPTVAWYKNDVEVLSPSMSNVSYLLSG-GNLLVPASSTLAYSSFHCTARNSLGEVR 230
            :.|...|.|:|..:|.||..:....:..|......| |.|::..........:.|.|.|..|...
  Fly    57 IECEADGQPEPEYSWIKNGKKFDWQAYDNRMLRQPGRGTLVITIPKDEDRGHYQCFASNEFGTAT 121

Worm   231 SPPILLKPSFIDPFRPHRLDVYSLATGGA-KLDCDAPAHQPKSLTYSWLYGSSTDRILS--QNER 292
            |..:.::.:.::.|:...........|.. .|.|.||...| |.|.:|:...|.|..:.  .|.|
  Fly   122 SNSVYVRKAELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFP-SPTVNWMIQESIDGSIKSINNSR 185

Worm   293 KFISLDGTLFFSYVTAEDEDS---YACS---------------------LSVYSTQSGHYGPFFR 333
            ..:..:|.|:||.||.||..|   ||||                     :.|.::|:.| .|..:
  Fly   186 MTLDPEGNLWFSNVTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGVSASQNKH-PPVRQ 249

Worm   334 LISSTPKLVNSTFPPKLDSTQPQIFPEDPKVGDSIYLECFAYASPLPQYKWSRVDGKPIPARSHI 398
            .:|....|.       |...:.::|             |....:||||..||: ||:.|.....|
  Fly   250 YVSRRQSLA-------LRGKRMELF-------------CIYGGTPLPQTVWSK-DGQRIQWSDRI 293

Worm   399 S--NYGRVLKIEKVNYGDAGKYKCVAMNAFGSAAG-EVHVKLRAPPSILQGLHDRLVPTESNVSF 460
            :  :||:.|.|.:.|:.|||.|.|...|..|:|.. .:.:.:.:.|...:.........:..|.|
  Fly   294 TQGHYGKSLVIRQTNFDDAGTYTCDVSNGVGNAQSFSIILNVNSVPYFTKEPEIATAAEDEEVVF 358

Worm   461 ECLLSNADSYSSVEWFKDAKPIVPLLLPAEKRKRLKIDHNVLHLKFADETDSGVYQCVASNDVGS 525
            ||..:.... ..:.|..:.|||.    .:....|..:..|.:.:....:.|:|.|.|.|:|.:|.
  Fly   359 ECRAAGVPE-PKISWIHNGKPIE----QSTPNPRRTVTDNTIRIINLVKGDTGNYGCNATNSLGY 418

Worm   526 SSSSALLTVKDSAPVF--PPNAMSRKVFAAFGSTVSIPCIFEASPRFHGKWADAGGSKLPQKGRI 588
            ......|.|:...|..  .|.|:|    ...|..|:|.|....||:...||..|  |.....||.
  Fly   419 VYKDVYLNVQAEPPTISEAPAAVS----TVDGRNVTIKCRVNGSPKPLVKWLRA--SNWLTGGRY 477

Worm   589 R-DEEGVISIEKVLHEDAGLFFCTAHNKLGKAHAQVQLIVVNKPSIKTNFLDEETVNMSCEVELT 652
            . ...|.:.|:.|...|||.:.|.|.||.|:..|...|:|.....|     .:|..|    .|:.
  Fly   478 NVQANGDLEIQDVTFSDAGKYTCYAQNKFGEIQADGSLVVKEHTRI-----TQEPQN----YEVA 533

Worm   653 CENSA--ECPEALFEWKINDRPAKEYPSLKSKVHEKKSGHKGRHLKQKVDLEV-PK--------- 705
            ...||  .|.||      :|      .:|:.::...|.|       |.:|.|. |:
  Fly   534 AGQSATFRCNEA------HD------DTLEIEIDWWKDG-------QSIDFEAQPRFVKTNDNSL 579

Worm   706 SLAGSRQI--GRFACSSLYGGSSEFVTKPQLPSPIA---LTVEQMDEDGK------KKKMFRLRW 759
            ::|.:.::  |.:.|          |.:.:|....|   |.|:.:....|      :.....:.|
  Fly   580 TIAKTMELDSGEYTC----------VARTRLDEATARANLIVQDVPNAPKLTGITCQADKAEIHW 634

Worm   760 RLPPQHRDTRDHSPKVEGYLVELRTR-KNRKWRAAERQLVGNMEKDSITVENLLPNTEYQFRVRS 823
            .   |..|.|  || :..|.::..|. ....|.||..::...   ||..|..:.|...|.|||.:
  Fly   635 E---QQGDNR--SP-ILHYTIQFNTSFTPASWDAAYEKVPNT---DSSFVVQMSPWANYTFRVIA 690

Worm   824 VESAAIGEPSIPSDWVKTAPGAPSETIDNLKWRSLDSQTLLVEWQPI-EIGQESSGDNLRYRVSW 887
            ........||..||...|.|..|.:..||:..:..:...|::.|.|: ||  |.:..|..|.|||
  Fly   691 FNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEI--EHNAPNFHYYVSW 753

Worm   888 SE---ATVGKNATDDMKLSNQDDDFENHL-DSDQPQAILKLNTTEGCRMVVLAVRPVNDQGNGSV 948
            ..   |...:|       :|..|..:|:: .:|||..:..|          :.|..:||:|..:|
  Fly   754 KRDIPAAAWEN-------NNIFDWRQNNIVIADQPTFVKYL----------IKVVAINDRGESNV 801

Worm   949 GTDTIAFLNSHGELKKVSLHNVKPINASHVNISWTWDNTSDCDTKHAVQITCINLSGSEISATVA 1013
            ..:.:  :...||                       |...|..|...::....:.||......|:
  Fly   802 AAEEV--VGYSGE-----------------------DRPLDAPTNFTMRQITSSTSGYMAWTPVS 841

Worm  1014 SDRIFWMLGGLEAETAYDCD----LKAI----DNHGS----FGPASKKF-RIHTK----QHPPS- 1060
            .:.:.....|.:.:|..:.:    |:.|    |.|.:    |.|.||.: ||...    ..|||
  Fly   842 EESVRGHFKGYKIQTWTENEGEEGLREIHVKGDTHNALVTQFKPDSKNYARILAYNGRFNGPPSA 906

Worm  1061 ----ETPLIGKLMMKQMKDTY-----TTILEWSSIELQKPNRTENG--CGYKIFI------YISE 1108
                :|| .|.....|..|.|     ..:|.|     :|| ...||  .||||:.      |:.|
  Fly   907 VIDFDTP-EGVPSPVQGLDAYPLGSSAFMLHW-----KKP-LYPNGKLTGYKIYYEEVKESYVGE 964

Worm  1109 TATEAIELDMPLQRLSDRRNPSARLDGLKLMYMYTIKVAGYNPGGIG 1155
            ..    |.|   ..::|.|....::.|||....|.|.:......|.|
  Fly   965 RR----EYD---PHITDPRVTRMKMAGLKPNSKYRISITATTKMGEG 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rig-6	NP_001022014.1	Ig	153..237	CDD:299845	16/70 (23%)
		Ig	240..335	CDD:299845	31/121 (26%)
		Ig	358..427	CDD:299845	23/70 (33%)
		IG_like	363..436	CDD:214653	24/75 (32%)
		I-set	441..534	CDD:254352	19/92 (21%)
		IGc2	456..524	CDD:197706	16/67 (24%)
		I-set	547..627	CDD:254352	26/80 (33%)
		Ig	552..627	CDD:299845	25/75 (33%)
		FN3	737..839	CDD:238020	27/111 (24%)
		fn3	970..1047	CDD:278470	14/88 (16%)
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	16/70 (23%)
		IG_like	57..127	CDD:214653	16/69 (23%)
		Ig	135..214	CDD:299845	26/79 (33%)
		IG_like	141..216	CDD:214653	26/75 (35%)
		ig	251..332	CDD:278476	28/101 (28%)
		I-set	339..427	CDD:254352	19/92 (21%)
		Ig	354..427	CDD:299845	18/77 (23%)
		I-set	432..517	CDD:254352	29/90 (32%)
		Ig	446..517	CDD:299845	25/72 (35%)
		I-set	522..611	CDD:254352	24/126 (19%)
		ig	525..609	CDD:278476	22/116 (19%)
		FN3	613..707	CDD:238020	24/102 (24%)
		FN3	716..807	CDD:238020	27/111 (24%)
		fn3	817..905	CDD:278470	18/87 (21%)
		FN3	917..1004	CDD:238020	25/99 (25%)
		FN3	1041..1111	CDD:238020
		Bravo_FIGEY	1155..>1221	CDD:290593
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910