DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scc-1 and vtd

DIOPT Version :9

Sequence 1:	NP_494836.1	Gene:	scc-1 / 173808	WormBaseID:	WBGene00004737	Length:	645	Species:	Caenorhabditis elegans
Sequence 2:	NP_001015132.1	Gene:	vtd / 3354896	FlyBaseID:	FBgn0260987	Length:	715	Species:	Drosophila melanogaster

Alignment Length:	758	Identity:	217/758 - (28%)
Similarity:	332/758 - (43%)	Gaps:	177/758 - (23%)

- Green bases have known domain annotations that are detailed below.

Worm     1 MFYAQFVLAKKGPLAKVWLAAHWEKKLTKAQIFETDVPQAIEEVIRPKVKMALRTVGHLLLGIVR 65
            |||...:||||||||::||||||:||:|||.:|||::.:::|.:::||||:||||.||||||:||
  Fly     1 MFYEHIILAKKGPLARIWLAAHWDKKITKAHVFETNIEKSVEGILQPKVKLALRTSGHLLLGVVR 65

Worm    66 IYSKKTRYLLADTNEAYQKMKINFRNGFSFEVDIPE-------NA-EIEEDFSNFIDKYNITVPE 122
            |||:|.:|||||.|||:.|:|:.||.|.   ||:||       || .:.|.|.:|    :..:||
  Fly    66 IYSRKAKYLLADCNEAFVKIKMAFRPGM---VDLPEGHREANVNAITLPEVFHDF----DTALPE 123

Worm   123 FHDADYNEQLIMANVSRREDITMKETVNFNVEFNIDADFDGFGDEGESWQLDHLYGSVEPLSLRP 187
            .:|.|...|..: |.||.::|||:|...   ..::....|||||.|...:
  Fly   124 LNDIDIEAQFSI-NQSRADEITMREDYG---SLSLSLQDDGFGDIGFEAE--------------- 169

Worm   188 TPQ------PESLMEVERDRDVAANGTEI-------------SRIDADSVIFSEGPTRPNLIFDN 233
            ||:      |.::.:...|.||..|...:             ||:|.|.  |.:...:|.|..|:
  Fly   170 TPEIIRCSIPSNINDKIFDNDVLENIESLDPHSLDAHADMPGSRLDGDG--FGDSFGQPALFEDD 232

Worm   234 QEGGNFMPEMNLKVENQTLEN--DGGVGPADMFSSMIHPVRE--HAVADVQNDDGMDFDYQPFE- 293
            ..|....|...:..|:.|:.|  |......|...::..|...  :::.|.:.::.::......|
  Fly   233 LFGDPSQPVEQITKESTTVLNADDSDEDAIDNIHNVPSPATSLVNSIEDEKEENNLNGHASVSEN 297

Worm   294 -PENVEPSRPQSPESFALEPLDVEHMEGRKKRQRKARKLIVDAETMISNDAFREQQEDFSDTMRV 357
             |.|.........|.|||.||||...:|..|.:|| ||||:|....||.:..:.|..|.||.:..
  Fly   298 VPMNEITLVQNEDEGFALAPLDVSMYKGVTKAKRK-RKLIIDEIKNISGEEMKAQLADTSDILTT 361

Worm   358 VEMAPPTRKMFNLCVSGDLQHLSREPGCKMFNRELLQRYRRCLVTR------------------E 404
            :::||||:::.....:|.::.|...|...:..|.|...|.|.|.:.                  |
  Fly   362 LDLAPPTKRLMYWKETGGVEKLFSLPSRSIPARALFGNYNRQLFSHSTFFEDFSSVVPMEILALE 426

Worm   405 FDLNYTMQ--------------ELSDSSS-----FTPSMEAQA-EPWEDLNLNEDI--------- 440
            |   ||.:              ..:|:.|     ..|....|: |..|.|..|...
  Fly   427 F---YTKENENALIIFNKKGRKRKNDNMSNLFLDHVPDSVVQSLEAPEVLRANHKSLGVSTVSVE 488

Worm   441 -----QEDIQAQGPAVDEFFNDVR------MDDDDDRQPAQEM---------DFGDNFD----FP 481
                 ||.|..|....  ||:::|      :::.:......|:         :.||:|:    .|
  Fly   489 IVSKEQESISCQNELT--FFDNMRSPDLLSLNEMEQFSSINELPLTPRNMNHEMGDDFNQGDSTP 551

Worm   482 QEVEHQECAPIPIQSGFAGENKEN------EDAEDWSDPFGSSNSSRRG---------------Q 525
            ..::|....|   |.|..||...:      :.|...::..|:|..|..|               :
  Fly   552 AGLDHGHATP---QHGNIGEMDHDSVIPTKKTAVILNESVGTSVLSDNGVSKRTNNILKGWDNYE 613

Worm   526 LEAY---GFGNTSTYKEDDGKWA-----KRAKHILKKVSADIETSGQADFSSVTATAKNRKQAAE 582
            :.::   ..|:.....|.|.::.     |||.|:...|.|........:.|.:| :..:|||||:
  Fly   614 IPSFVGQNHGDEQMENETDEQFEERVLNKRAAHLFIDVRAHFIAKDSLELSQLT-SGNSRKQAAQ 677

Worm   583 QFYSLLTLAKSQAISVDQSEPYGEIVIRPGANFKEACPLSSPK 625
            :|||||.|.|.:.:.:|||.||.:|.|..|..|:      :||
  Fly   678 KFYSLLVLKKFKVLHIDQSAPYADITITRGPTFE------NPK 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scc-1	NP_494836.1	Rad21_Rec8_N	1..109	CDD:282655	66/115 (57%)
scc-1	NP_494836.1	Rad21_Rec8	561..615	CDD:282654	22/53 (42%)
vtd	NP_001015132.1	Rad21_Rec8_N	1..106	CDD:282655	63/107 (59%)
vtd	NP_001015132.1	Rad21_Rec8	657..710	CDD:282654	22/53 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165750
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1213
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	260	1.000	Inparanoid score	I1918
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1253899at2759
OrthoFinder	1	1.000	-	-		FOG0001363
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103388
Panther	1	1.100	-	-	O	PTHR12585
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1058
SonicParanoid	1	1.000	-	-		X1093
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.790