DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mme and Nepl4

DIOPT Version :9

Sequence 1:	NP_001276391.1	Gene:	Mme / 17380	MGIID:	97004	Length:	750	Species:	Mus musculus
Sequence 2:	NP_609019.1	Gene:	Nepl4 / 33889	FlyBaseID:	FBgn0031805	Length:	652	Species:	Drosophila melanogaster

Alignment Length:	774	Identity:	172/774 - (22%)
Similarity:	285/774 - (36%)	Gaps:	235/774 - (30%)

- Green bases have known domain annotations that are detailed below.

Mouse    55 GICKSSDCIKSAARLIQNMDASVEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILK 119
            |.|.|:...:....|:..:|:...||.||:.||||.|..::....|::..|...|.| :.|.:..
  Fly    36 GECNSTINQQHIDTLMSYVDSEKNPCEDFYAYACGKWRAKHGSHTTATMISESQINR-QYEDLFL 99

Mouse   120 DVLQEPKTEDIVAVQKAKTL--YRSCINESAIDSRGGQPLLKLLP-DIYGWPVASDNWDQTYGTS 181
            .:|:.|...:......||.|  |:|||   |::....:..::||. |:    :||.|     .|.
  Fly   100 QLLRNPSAPEYGYPMFAKVLAHYQSCI---ALEKPDLRRYIELLDRDL----LASLN-----STH 152

Mouse   182 WTAEKSIAQLNSKYG-----KKVLINFFVGTDDKNSTQHII----HFDQPRLGLPSRDYYECTGI 237
            |.  ..:|.| .:||     .:|.:.::      |:|.|:|    |.....|.| ::|.|:.
  Fly   153 WM--HLLAAL-GRYGYHGHYVQVEVRWY------NATHHMIFLLPHNRHLNLSL-TQDIYDA--- 204

Mouse   238 YKEACTAYVDFMISVARLIRQEQSLP----IDENQLSLEMNKVMELEKEIANATTKPEDRNDPML 298
                             |.:...|.|    :.|...|||.|.|         ...||...:|..
  Fly   205 -----------------LSQDGSSWPPLHQLQEQFRSLEQNLV---------RLAKPHSADDTF- 242

Mouse   299 LYNKMTLAKLQNNFSL-----EVNGKSFSWSNFTNEIMSTV-------NINIQNEE-EVVVYAPE 350
                       .|:||     ||.|  ..|    :|.:.|.       |...|.:: :.:....|
  Fly   243 -----------RNYSLDQIRTEVPG--LHW----DEALRTQLGRSVPGNHVFQVDDLDAIEGLVE 290

Mouse   351 YLTKLKP-ILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATW------ 408
            ||..:.. :|.:||..        ||:..|: .|..|                 ..|||
  Fly   291 YLNTVDTLLLNRYSLA--------RFLSHLL-ELPHN-----------------PLATWESGQRS 329

Mouse   409 --RRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEE 471
              |.|..::..::...:..:| |.:|....:| .::|:  |..||.|       :.::.:.:.:.
  Fly   330 RGRNCIRHMRRSVYLPMNYVY-ERSFYSRRRH-ADELV--IHSVFQQ-------LQSQLELRVQH 383

Mouse   472 KALAIKERIGYPDDIIS------NENKLNNEYLELNYRED-------------EYFENIIQNLKF 517
            .|..:.:      |::.      ::.::|...|..|..|.             :::||.:.:|.:
  Fly   384 NAFNLSQ------DLVKSLQAKVHQMRINVGNLPPNVTEQFYWDSDRRWSVGRDFYENHLNSLLY 442

Mouse   518 SQS--KQLKKLREKVDKDEWIS----------GAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQS 570
            ..:  ..|:...::.::|.|.|          .......||..| |.|..|...::.|||.|...
  Fly   443 YYTLVADLESSSDQEERDIWYSFNMHTPEFPDNIDATPYFYCLG-NIIFVPYSYVKRPFFDANFW 506

Mouse   571 NSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFSWDLAG 635
            .:|.||.:...:||||.|.||.         ||||:..|.:..||.||              |..
  Fly   507 PALLYGDLANTLGHEIMHAFDT---------DLVDYDAQGNLRNFSDQ--------------LGE 548

Mouse   636 GQHLNG----INT----LGENIADNGGIGQAYRAY-QNYVKKNGEEKLLPGLDLNHKQLFFLNFA 691
            .:..||    :|:    |.|..:|..|...|.:.| .:::.::|           :.:|:||.||
  Fly   549 VELYNGAVGCLNSSAVMLNERTSDVSGSRLAMQTYGGDWLTRSG-----------NGRLYFLQFA 602

Mouse   692 QVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW 750
            ..:||....:|         |..|:.|:...|....:||:.|.|...|.|....:|..|
  Fly   603 HFFCGDEGDQY---------HDSGSQRLNYALGQVPQFAEVFRCHVGSGMTSADQCPFW 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mme	NP_001276391.1	Stop-transfer sequence. /evidence=ECO:0000255	16..23
Mme	NP_001276391.1	M13	77..748	CDD:341056	165/748 (22%)
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	165/748 (22%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:301352	165/746 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920