DRSC/TRiP Functional Genomics Resources

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Protein Alignment DKC1 and CBF5

DIOPT Version :10

Sequence 1:NP_001354.1 Gene:DKC1 / 1736 HGNCID:2890 Length:514 Species:Homo sapiens
Sequence 2:NP_013276.1 Gene:CBF5 / 850872 SGDID:S000004165 Length:483 Species:Saccharomyces cerevisiae


Alignment Length:480 Identity:304/480 - (63%)
Similarity:371/480 - (77%) Gaps:9/480 - (1%)


- Green bases have known domain annotations that are detailed below.


Human    34 EEFLIKPESKVAKLDTSQWPLLLKNFDKLNVRTTHYTPLACGSNPLKREIGDYIRTGFINLDKPS 98
            |:|:||||:..|..|||:|||||||||||.||:.||||:..||:||||::..||.:|.|||||||
Yeast     4 EDFVIKPEAAGASTDTSEWPLLLKNFDKLLVRSGHYTPIPAGSSPLKRDLKSYISSGVINLDKPS 68

Human    99 NPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAI 163
            |||||||||||:||||.|||||||||||||||||||||:||||||||||.||||||.|||||:|:
Yeast    69 NPSSHEVVAWIKRILRCEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHDAL 133

Human   164 EGGTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRT 228
            :....|.|:||.||||||||||||:||||||||||||||.:||:|.:|.||:||.|||||||:||
Yeast   134 KDEKDLGRSLENLTGALFQRPPLISAVKRQLRVRTIYESNLIEFDNKRNLGVFWASCEAGTYMRT 198

Human   229 LCVHLGLLLGVGGQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLL 293
            ||||||:||||||.||||||||||.:||.|:|||:|||:||||:|||.:||||||.::.|||.||
Yeast   199 LCVHLGMLLGVGGHMQELRRVRSGALSENDNMVTLHDVMDAQWVYDNTRDESYLRSIIQPLETLL 263

Human   294 TSHKRLVMKDSAVNAICYGAKIMLPGVLRYEDGIEVNQEIVVITTKGEAICMAIALMTTAVISTC 358
            ..:||:|:|||||||:|||||:|:||:||||:|||:..|||:||||||||.:|||.|:|..:::|
Yeast   264 VGYKRIVVKDSAVNAVCYGAKLMIPGLLRYEEGIELYDEIVLITTKGEAIAVAIAQMSTVDLASC 328

Human   359 DHGIVAKIKRVIMERDTYPRKWGLGPKASQKKLMIKQGLLDKHGKPTDSTPATWKQEYVDYSESA 423
            |||:||.:||.|||||.|||:|||||.|.:||.|...|.|||:|:..::||..||:|||....:.
Yeast   329 DHGVVASVKRCIMERDLYPRRWGLGPVAQKKKQMKADGKLDKYGRVNENTPEQWKKEYVPLDNAE 393

Human   424 KKEVVAEVVKAPQVVAEAAKTAKRKRESESESDETPPAAPQLIKKEK--------KKSKKDKK-A 479
            :....::..|..:...:.||.....:|.|:|.:|......:..||||        ||.||||| .
Yeast   394 QSTSSSQETKETEEEPKKAKEDSLIKEVETEKEEVKEDDSKKEKKEKKDKKEKKEKKEKKDKKEK 458

Human   480 KAGLESGAEPGDGDSDTTKKKKKKK 504
            |...|...:..||||:..|.||.||
Yeast   459 KEKKEKKRKSEDGDSEEKKSKKSKK 483

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DKC1NP_001354.1 Nucleolar localization 2..21
CBF5 56..381 CDD:273073 240/324 (74%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 443..514 27/71 (38%)
Nuclear and nucleolar localization 446..514 26/68 (38%)
CBF5NP_013276.1 CBF5 26..351 CDD:273073 240/324 (74%)
Blue background indicates that the domain is not in the aligned region.

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