Protein Alignment DKC1 and dkc1

DIOPT Version :10

• Sequence 1: NP_001354.1
• Gene: DKC1 / 1736
• HGNCID: 2890
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_001028279.2
• Gene: dkc1 / 613144
• ZFINID: ZDB-GENE-031118-120
• Length: 506
• Species: Danio rerio
• Alignment Length: 524
• Identity: 394/524 - (75%)
• Similarity: 442/524 - (84%)
• Gaps: 28/524 - (5%)

Human     1 MADAEVIILPKKHKKKKERKSLPEEDVAEIQHAEEFLIKPESKVAKLDTSQWPLLLKNFDKLNVR 65
            |||.|    .||.||:|.:| :.:|:|.:||.:.:||||||||||.|||||||||||||||||:|
Zfish     1 MADTE----SKKEKKRKSKK-ISDEEVGDIQESGDFLIKPESKVASLDTSQWPLLLKNFDKLNIR 60

Human    66 TTHYTPLACGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTG 130
            |.|||||..|||||||.|.||:|:||||||||:|||||||||||:||||||||||||||||||||
Zfish    61 TAHYTPLPHGSNPLKRGIHDYVRSGFINLDKPANPSSHEVVAWIKRILRVEKTGHSGTLDPKVTG 125

Human   131 CLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQLR 195
            |||||:||||||||||||||||||||||||||:|...||:||||.||||||||||||||||||||
Zfish   126 CLIVCVERATRLVKSQQSAGKEYVGIVRLHNALENEHQLARALECLTGALFQRPPLIAAVKRQLR 190

Human   196 VRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKDHM 260
            ||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||:.|||::
Zfish   191 VRTIYESKLIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVLGEKDNL 255

Human   261 VTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGVLRYED 325
            |||||||||||.:|::|||:|||||::||||||.||||:||||||||||||||||||||||||||
Zfish   256 VTMHDVLDAQWQFDHNKDETYLRRVIFPLEKLLISHKRIVMKDSAVNAICYGAKIMLPGVLRYED 320

Human   326 GIEVNQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKK 390
            ||||||:||||||||||||.|:||||||||||||||:||||||||||||||||||||||||||||
Zfish   321 GIEVNQDIVVITTKGEAICTAVALMTTAVISTCDHGVVAKIKRVIMERDTYPRKWGLGPKASQKK 385

Human   391 LMIKQGLLDKHGKPTDSTPATWKQEYVDYSESAKKEVVAEVVKAPQVVAEAAKTAKRKRESESES 455
            :||::|||||||||.:|||:.||:.|||||.:..|:           ..||  :|||||:.....
Zfish   386 MMIQKGLLDKHGKPNNSTPSDWKEGYVDYSTTKVKK-----------GGEA--SAKRKRDESGSE 437

Human   456 DETPPAA------PQLIKKEKKKSKKDKKAKAGLESGAE-PGDGDSDTT---KKKKKKKKAKEVE 510
            .|...||      .:..||||||.||:||.|...|:.|| |.:.:::.|   |||||||||||.|
Zfish   438 GEAAAAAQDTSKTEEESKKEKKKKKKEKKQKLAEEAAAEAPAEEETEVTESAKKKKKKKKAKETE 502

Human   511 LVSE 514
            ..|:
Zfish   503 ADSD 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DKC1	NP_001354.1	Nucleolar localization	2..21		8/18 (44%)
		CBF5	56..381	CDD:273073	289/324 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	443..514		36/80 (45%)
		Nuclear and nucleolar localization	446..514		35/77 (45%)
dkc1	NP_001028279.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		12/29 (41%)
		CBF5	51..376	CDD:273073	289/324 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	391..410		14/18 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	419..506		39/99 (39%)