DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DKC1 and Nop60B

DIOPT Version :9

Sequence 1:	NP_001354.1	Gene:	DKC1 / 1736	HGNCID:	2890	Length:	514	Species:	Homo sapiens
Sequence 2:	NP_001014547.1	Gene:	Nop60B / 37873	FlyBaseID:	FBgn0259937	Length:	508	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	340/518 - (65%)
Similarity:	409/518 - (78%)	Gaps:	28/518 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     1 MADAEVIILPKKHKKKKERKSLP--EEDVAEIQHAEEFLIKPESKVAKLDTSQWPLLLKNFDKLN 63
            |||.||    :|.||||:.|..|  .:|:..:|....|.|||.||:|:|||||||||||||||||
  Fly     1 MADVEV----RKEKKKKKIKEEPLDGDDIGTLQKQGNFQIKPSSKIAELDTSQWPLLLKNFDKLN 61

Human    64 VRTTHYTPLACGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKV 128
            :|:.||||||.||:||.|:|.:|::|||||||||||||||||||||::||:||||||||||||||
  Fly    62 IRSNHYTPLAHGSSPLNRDIKEYMKTGFINLDKPSNPSSHEVVAWIKKILKVEKTGHSGTLDPKV 126

Human   129 TGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQ 193
            ||||||||:|||||||||||||||||.|.:||.|:|...::.:.||.|.||||||||||:|||||
  Fly   127 TGCLIVCIDRATRLVKSQQSAGKEYVAIFKLHGAVESVAKVRQGLEKLRGALFQRPPLISAVKRQ 191

Human   194 LRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKD 258
            |||||:|:||:::||..|.:|:||||||||:||||:||||||:|||||||.||||||||:.||:|
  Fly   192 LRVRTVYDSKLLDYDETRNMGVFWVSCEAGSYIRTMCVHLGLVLGVGGQMLELRRVRSGIQSERD 256

Human   259 HMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGVLRY 323
            .||||||||||.|||:||||||.||||:.|||.||.:|||::||||:|||:||||||.|||||||
  Fly   257 GMVTMHDVLDAMWLYENHKDESMLRRVIKPLEGLLVNHKRIIMKDSSVNAVCYGAKITLPGVLRY 321

Human   324 EDGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQ 388
            |||||::||||:.||||||||:||||||||.:::||||:|||||||||||||||||||||||||.
  Fly   322 EDGIEIDQEIVICTTKGEAICLAIALMTTATMASCDHGVVAKIKRVIMERDTYPRKWGLGPKASA 386

Human   389 KKLMIKQGLLDKHGKPTDSTPATWKQEYVDYSESAKKEVVAEVVKAPQVVAEAAKTAKRKRESES 453
            ||.:|..|.|||.|:|.::||..|...||||  :|||....||  :|  ...:::.:|||..:.|
  Fly   387 KKALIAAGKLDKFGRPNENTPKEWLTGYVDY--NAKKPAAQEV--SP--TNGSSEPSKRKLSTSS 445

Human   454 --------ESDETPPAAPQLIKKEKKKSKKDKKAKAGLESGAEPGDGDSDTTKKKKKKKKAKE 508
                    .|:|||....   ||:|||.|.|::|....|..|||.:     .:|||||||.|:
  Fly   446 VEETAAAAVSEETPSKDK---KKKKKKHKGDEEAPEAAEEEAEPVE-----KEKKKKKKKDKD 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DKC1	NP_001354.1	Nucleolar localization	2..21		9/18 (50%)
		CBF5	56..381	CDD:273073	252/324 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..514		28/74 (38%)
		Nuclear and nucleolar localization	446..514		28/71 (39%)
Nop60B	NP_001014547.1	DKCLD	47..104	CDD:285330	45/56 (80%)
		CBF5	54..379	CDD:273073	252/324 (78%)
		PseudoU_synth_hDyskerin	86..268	CDD:211338	142/181 (78%)
		PUA	295..368	CDD:279774	57/72 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154949
Domainoid	1	1.000	185	1.000	Domainoid score	I3399
eggNOG	1	0.900	-	-		E1_COG0130
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1045
Inparanoid	1	1.050	665	1.000	Inparanoid score	I763
Isobase	1	0.950	-	0.906565	Normalized mean entropy	S134
OMA	1	1.010	-	-		QHG54015
OrthoDB	1	1.010	-	-		D1070373at2759
OrthoFinder	1	1.000	-	-		FOG0005182
OrthoInspector	1	1.000	-	-		oto90642
orthoMCL	1	0.900	-	-		OOG6_100327
Panther	1	1.100	-	-	LDO	PTHR23127
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R170
SonicParanoid	1	1.000	-	-		X3697
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750