DRSC/TRiP Functional Genomics Resources

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Protein Alignment DKC1 and cbf5

DIOPT Version :10

Sequence 1:NP_001354.1 Gene:DKC1 / 1736 HGNCID:2890 Length:514 Species:Homo sapiens
Sequence 2:NP_594878.1 Gene:cbf5 / 2542481 PomBaseID:SPAC29A4.04C Length:474 Species:Schizosaccharomyces pombe


Alignment Length:488 Identity:313/488 - (64%)
Similarity:382/488 - (78%) Gaps:36/488 - (7%)


- Green bases have known domain annotations that are detailed below.


Human    35 EFLIKPE-SKVAKLDTSQWPLLLKNFDKLNVRTTHYTPLACGSNPLKREIGDYIRTGFINLDKPS 98
            :|:|||| :..:|:||::|||||||||||.|||.||||:.||:|||||.|.:|:.:|.||||||:
pombe     9 DFMIKPEATSASKIDTAEWPLLLKNFDKLLVRTGHYTPIPCGNNPLKRPIAEYVSSGVINLDKPA 73

Human    99 NPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAI 163
            ||||||||||:::||||||||||||||||||||||:|.:|||||||||||||||||.::|||:::
pombe    74 NPSSHEVVAWVKKILRVEKTGHSGTLDPKVTGCLIICNDRATRLVKSQQSAGKEYVCVLRLHDSV 138

Human   164 EGGTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRT 228
            ||...::.|:||||||||||||||:|||||||:|:|||||:||:|.||.|.:||.|||||||:||
pombe   139 EGERNVASAIETLTGALFQRPPLISAVKRQLRIRSIYESKLIEFDNERNLAVFWASCEAGTYMRT 203

Human   229 LCVHLGLLLGVGGQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLL 293
            |||||||||||||.||||||||||.:||.|.:|||||||||||:|||.:||||||||:.|||.||
pombe   204 LCVHLGLLLGVGGHMQELRRVRSGCLSENDDIVTMHDVLDAQWIYDNTRDESYLRRVIRPLESLL 268

Human   294 TSHKRLVMKDSAVNAICYGAKIMLPGVLRYEDGIEVNQEIVVITTKGEAICMAIALMTTAVISTC 358
            ..:||:|:|||||||||||||:|:||:||||.|||||:|||:||||||||.:.||.|:|..:|||
pombe   269 VGYKRIVVKDSAVNAICYGAKLMIPGLLRYEAGIEVNEEIVLITTKGEAIAVGIAQMSTVELSTC 333

Human   359 DHGIVAKIKRVIMERDTYPRKWGLGPKASQKKLMIKQGLLDKHGKPTDSTPATWKQEYVDYSESA 423
            |||:|||:||.|||||.|||:|||||::.:||.:.|:|.|||:|:|.::|||.|.:.|:|||:..
pombe   334 DHGVVAKVKRCIMERDVYPRRWGLGPQSMKKKTLKKEGKLDKYGRPNENTPADWSKSYIDYSDPN 398

Human   424 KKEVVAEVVKAPQVVAEAAKTA-----------KRK--RESESESDETPPAAPQLIKKEKKKSKK 475
                 |||.|...|||.||.|.           |||  ..||.:.||......:..|||.||.||
pombe   399 -----AEVAKPAPVVAPAAPTVEAEVNGVEDSKKRKSVESSEKDEDEAAKKEEKRRKKEAKKEKK 458

Human   476 DKKAKAGLESGAEPGDGDSDTTKKKKKKKKAKE 508
            :||.|                 |:||:|||..|
pombe   459 EKKEK-----------------KEKKEKKKKSE 474

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DKC1NP_001354.1 Nucleolar localization 2..21
CBF5 56..381 CDD:273073 245/324 (76%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 443..514 25/79 (32%)
Nuclear and nucleolar localization 446..514 24/65 (37%)
cbf5NP_594878.1 CBF5 31..356 CDD:273073 245/324 (76%)
Blue background indicates that the domain is not in the aligned region.

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