Protein Alignment DKC1 and Dkc1

DIOPT Version :10

• Sequence 1: NP_001354.1
• Gene: DKC1 / 1736
• HGNCID: 2890
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_001346340.1
• Gene: Dkc1 / 245474
• MGIID: 1861727
• Length: 534
• Species: Mus musculus
• Alignment Length: 510
• Identity: 462/510 - (90%)
• Similarity: 479/510 - (93%)
• Gaps: 5/510 - (0%)

Human     5 EVIILPKKHKKKKERKSLPEEDVAEIQHAEEFLIKPESKVAKLDTSQWPLLLKNFDKLNVRTTHY 69
            ::|..||||||||:||.|.|:||||||||||||||||||||:||||||||||||||||||||.||
Mouse    30 KLITFPKKHKKKKDRKPLQEDDVAEIQHAEEFLIKPESKVAQLDTSQWPLLLKNFDKLNVRTAHY 94

Human    70 TPLACGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIV 134
            |||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    95 TPLPCGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIV 159

Human   135 CIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQLRVRTI 199
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   160 CIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQLRVRTI 224

Human   200 YESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKDHMVTMH 264
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   225 YESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKDHMVTMH 289

Human   265 DVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGVLRYEDGIEV 329
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||
Mouse   290 DVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGLLRYEDGIEV 354

Human   330 NQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKLMIK 394
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||
Mouse   355 NQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKMMIK 419

Human   395 QGLLDKHGKPTDSTPATWKQEYVDYSESAKKEVVAEVVKAPQVVAEAAKTAKRKRESESESDETP 459
            ||||||||||||:|||||||:|:|||:|.|..:|.|.|:|||:.|||....||||:||||||||
Mouse   420 QGLLDKHGKPTDNTPATWKQDYIDYSDSGKNTLVTEAVQAPQLAAEAVNVIKRKRDSESESDET- 483

Human   460 PAAPQLIKKEKKKSKKDKKAKAGLESGAEPGDGDSDTTKKKKKKKKAKEVELVSE 514
            |..|||  ||||| |||||.|..||||.|.||||:||| |||||||.|.||.:||
Mouse   484 PTVPQL--KEKKK-KKDKKPKTVLESGGETGDGDNDTT-KKKKKKKVKVVEEMSE 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DKC1	NP_001354.1	Nucleolar localization	2..21		10/15 (67%)
		CBF5	56..381	CDD:273073	321/324 (99%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	443..514		49/70 (70%)
		Nuclear and nucleolar localization	446..514		49/67 (73%)
Dkc1	NP_001346340.1	CBF5	81..406	CDD:273073	321/324 (99%)