Protein Alignment DKC1 and dkc-1

DIOPT Version :10

• Sequence 1: NP_001354.1
• Gene: DKC1 / 1736
• HGNCID: 2890
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_499370.1
• Gene: dkc-1 / 176504
• WormBaseID: WBGene00010478
• Length: 445
• Species: Caenorhabditis elegans
• Alignment Length: 481
• Identity: 296/481 - (61%)
• Similarity: 358/481 - (74%)
• Gaps: 38/481 - (7%)

Human    15 KKKERKSLPEEDVAEIQHAEEFLIKPESKVAKLDTSQWPLLLKNFDKLNVRTTHYTPLACGSNPL 79
            ||.:|..|..:|:||.|....|.:...::.||||.|||||||||:|||||||.||||...|.:||
 Worm     3 KKDKRSKLEGDDLAEAQQKGSFQLPSSNETAKLDASQWPLLLKNYDKLNVRTNHYTPHVEGVSPL 67

Human    80 KREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVK 144
            ||:|.:||.:||.||||||||||||||:||:||||.|||||||||||||:|||||||:|.|||.|
 Worm    68 KRDIKNYISSGFFNLDKPSNPSSHEVVSWIKRILRCEKTGHSGTLDPKVSGCLIVCIDRTTRLAK 132

Human   145 SQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDP 209
            |||.|||||:.|.:||..:|...::.:|||.||||||||||||:|||||||:||:||:|.|||||
 Worm   133 SQQGAGKEYICIFKLHEEVEDDRKVKQALEKLTGALFQRPPLISAVKRQLRIRTVYENKFIEYDP 197

Human   210 ERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYD 274
            .:::|||...||:|||:||:||||||:||.|||||||||.|||:..|.::|||||||||||:|.|
 Worm   198 AQQMGIFNCICESGTYVRTICVHLGLILGCGGQMQELRRNRSGICDENENMVTMHDVLDAQYLLD 262

Human   275 NHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGVLRYEDGIEVNQEIVVITTK 339
            ..|||||:|.:|.|||.|||.|||:|:|||.:|||||||||::||:|||:|.|||.:|||:::||
 Worm   263 TQKDESYMRHIVRPLEALLTQHKRVVVKDSCINAICYGAKILIPGILRYDDDIEVGKEIVIMSTK 327

Human   340 GEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKLMIKQGLLDKHGKP 404
            |||||:|||.|.|:.|::.|||:|||.||||||||.|.|||||||.||:||.|:|.|||||.|||
 Worm   328 GEAICIAIAQMNTSTIASVDHGVVAKSKRVIMERDVYGRKWGLGPVASKKKQMVKDGLLDKFGKP 392

Human   405 TDSTPATWKQEYVDYSESAKKEVVAEVVKAPQVVAEAAKTAKRKRESESESDETPPAAPQLIKKE 469
            .|:||.:|.:|||  ..|.||||                   :|.|:..|.:|..|
 Worm   393 NDTTPKSWAKEYV--QTSTKKEV-------------------KKEETPDEEEEEAP--------- 427

Human   470 KKKSKKDKKAKAGLESGAEPGDGDSD 495
            ||||||.||        .|..|.|||
 Worm   428 KKKSKKSKK--------QESSDSDSD 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DKC1	NP_001354.1	Nucleolar localization	2..21		3/5 (60%)
		CBF5	56..381	CDD:273073	228/324 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	443..514		18/53 (34%)
		Nuclear and nucleolar localization	446..514		18/50 (36%)
dkc-1	NP_499370.1	CBF5	44..369	CDD:273073	228/324 (70%)