Protein Alignment DKC1 and Dkc1

DIOPT Version :10

• Sequence 1: NP_001354.1
• Gene: DKC1 / 1736
• HGNCID: 2890
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_596910.1
• Gene: Dkc1 / 170944
• RGDID: 621780
• Length: 509
• Species: Rattus norvegicus
• Alignment Length: 509
• Identity: 424/509 - (83%)
• Similarity: 463/509 - (90%)
• Gaps: 5/509 - (0%)

Human     1 MADAE-VIILPKKHKKKKERKSLPEEDVAEIQHAEEFLIKPESKVAKLDTSQWPLLLKNFDKLNV 64
            ||||| .:..|||||||||||.|||.|||||||||:||||||||.|:||||||||||||||:|||
  Rat     1 MADAEAAMTFPKKHKKKKERKPLPEADVAEIQHAEDFLIKPESKAAQLDTSQWPLLLKNFDRLNV 65

Human    65 RTTHYTPLACGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVT 129
            |||||||:.|||||||||||:|:||||||||||||||||||||||||||||||||||||||||||
  Rat    66 RTTHYTPIPCGSNPLKREIGEYVRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVT 130

Human   130 GCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQL 194
            ||||||||||||||||||||||||||:|||||||||..|||||||||||||||||||||||||||
  Rat   131 GCLIVCIERATRLVKSQQSAGKEYVGVVRLHNAIEGTAQLSRALETLTGALFQRPPLIAAVKRQL 195

Human   195 RVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKDH 259
            ||||||||:::|||||||||:||||||||||||||||||||||||||||||||||||||:.|:||
  Rat   196 RVRTIYESRVVEYDPERRLGVFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVVGERDH 260

Human   260 MVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGVLRYE 324
            |||||||||||:|||:|:|||||||||:||||||||||||||||||||||||||||||||:||||
  Rat   261 MVTMHDVLDAQYLYDHHRDESYLRRVVFPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGLLRYE 325

Human   325 DGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQK 389
            ||||||||:|||||||||:|:||||||||||||||||:|||||||||||||||||||||||||||
  Rat   326 DGIEVNQEVVVITTKGEAVCVAIALMTTAVISTCDHGVVAKIKRVIMERDTYPRKWGLGPKASQK 390

Human   390 KLMIKQGLLDKHGKPTDSTPATWKQEYVDYSESAKKEVVAEVVKAPQVVAEAAKTAKRKRESESE 454
            |.:||||||||||:|||.|||:|.::|||||:|:||...||....|.|.|:||...||||:|:|:
  Rat   391 KQLIKQGLLDKHGRPTDGTPASWTRDYVDYSDSSKKATAAEATPGPGVTADAASIVKRKRDSDSD 455

Human   455 SDETPPAAPQLIKKEKKKSKKDKKAKAGLESGAEPGDGDSDTTKKKKKKKKAKE 508
            :||..|.....:||||||.|  :||..| |..||.||||: |.||||||.:|.|
  Rat   456 ADEATPTTTPRVKKEKKKKK--EKADGG-EEAAEDGDGDA-TRKKKKKKARAAE 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DKC1	NP_001354.1	Nucleolar localization	2..21		14/19 (74%)
		CBF5	56..381	CDD:273073	300/324 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	443..514		35/66 (53%)
		Nuclear and nucleolar localization	446..514		35/63 (56%)
Dkc1	NP_596910.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25		17/23 (74%)
		Nucleolar localization. /evidence=ECO:0000250	2..22		14/19 (74%)
		CBF5	57..382	CDD:273073	300/324 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	381..509		78/129 (60%)
		Nuclear and nucleolar localization. /evidence=ECO:0000250	447..509		35/63 (56%)