Protein Alignment DKC1 and dkc1

DIOPT Version :10

• Sequence 1: NP_001354.1
• Gene: DKC1 / 1736
• HGNCID: 2890
• Length: 514
• Species: Homo sapiens
• Sequence 2: XP_012824635.1
• Gene: dkc1 / 100145077
• XenbaseID: XB-GENE-5766174
• Length: 555
• Species: Xenopus tropicalis
• Alignment Length: 539
• Identity: 398/539 - (73%)
• Similarity: 443/539 - (82%)
• Gaps: 30/539 - (5%)

Human     1 MADAEVIILPKKHKKKKERKSLPEEDVAEIQHAEEFLIKPESKVAKLDTSQWPLLLKNFDKLNVR 65
            |||.|.   .||..||:..:.|..||||:|||..:||||||||||:|||||||||||||||||:|
 Frog     1 MADGEG---SKKKAKKRRSQILGAEDVADIQHEGDFLIKPESKVAQLDTSQWPLLLKNFDKLNIR 62

Human    66 TTHYTPLACGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTG 130
            |.||||:..|||||||||.:||:|||||||||:||||||||||||||||.|||||||||||||||
 Frog    63 TAHYTPIPSGSNPLKREISEYIKTGFINLDKPANPSSHEVVAWIRRILRSEKTGHSGTLDPKVTG 127

Human   131 CLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQLR 195
            ||||||:|||||||||||||||||||||||||:|...||||||||||||||||||||||||||||
 Frog   128 CLIVCIDRATRLVKSQQSAGKEYVGIVRLHNALENELQLSRALETLTGALFQRPPLIAAVKRQLR 192

Human   196 VRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKDHM 260
            ||||||||:||||||||||||||||||||||||||||:||||||||||||||||||||:.|||::
 Frog   193 VRTIYESKLIEYDPERRLGIFWVSCEAGTYIRTLCVHIGLLLGVGGQMQELRRVRSGVLGEKDNL 257

Human   261 VTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGVLRYED 325
            |||||||||||.:||:|||||||||::||||||.|||||||||||||||||||||||||:|||||
 Frog   258 VTMHDVLDAQWQFDNNKDESYLRRVIFPLEKLLVSHKRLVMKDSAVNAICYGAKIMLPGLLRYED 322

Human   326 GIEVNQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKK 390
            |||:|||||||||||||||:|:||||||||||||||:||||||||||||||||||||||||||||
 Frog   323 GIELNQEIVVITTKGEAICIAVALMTTAVISTCDHGVVAKIKRVIMERDTYPRKWGLGPKASQKK 387

Human   391 LMIKQGLLDKHGKPTDSTPATWKQEYVDYSESAKKEVVAEVVKAPQV------VAEAAKTAKRKR 449
            :||::|||||||||.:|||:.|||||||||.:.|.:..|:..|...|      .||.:...|:|:
 Frog   388 MMIQKGLLDKHGKPNESTPSGWKQEYVDYSATPKIQQAADAPKRKHVSETDSDSAEPSTLKKKKK 452

Human   450 ESESESDE-------TPPAAPQLIKKEKKKSKKDKKAKAGLESGAE---------PGDGDSDT-- 496
            :.|||..|       :..|.|  :|..|||.||||......|:.|.         .|..:.:|
 Frog   453 KLESEDKEEHVDNADSDAATP--VKSSKKKKKKDKGGDTENETAAHSEKSKEMETAGSDEGETVL 515

Human   497 -TKKKKKKKKAKEVELVSE 514
             |||||||.|.:|.|..:|
 Frog   516 KTKKKKKKDKTEERESPAE 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DKC1	NP_001354.1	Nucleolar localization	2..21		7/18 (39%)
		CBF5	56..381	CDD:273073	292/324 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	443..514		30/89 (34%)
		Nuclear and nucleolar localization	446..514		30/86 (35%)
dkc1	XP_012824635.1	CBF5	53..378	CDD:273073	292/324 (90%)