Protein Alignment Aff1 and lilli

DIOPT Version :9

• Sequence 1: NP_001074267.1
• Gene: Aff1 / 17355
• MGIID: 1100819
• Length: 1226
• Species: Mus musculus
• Sequence 2: NP_001137775.1
• Gene: lilli / 33496
• FlyBaseID: FBgn0041111
• Length: 1673
• Species: Drosophila melanogaster
• Alignment Length: 1793
• Identity: 343/1793 - (19%)
• Similarity: 553/1793 - (30%)
• Gaps: 758/1793 - (42%)

Mouse    15 LYNEDRNLLRIREKERRNQEAHQEKEAF---PEKAPLFPEPYKTAKGDELSSRIQTMLGDYEEMK 76
            ||:::.|:.....::||.:|..:.::..   ..:..||.||.:..:||   :.|...||::.|.:
  Fly    53 LYSQNYNMEEYERRKRREREKIERQQGIQIDDRETSLFGEPRRLTEGD---AEITAALGEFFEAR 114

Mouse    77 EFLSSKSHPHRLDGSEDRPGKPRYPLGHDRGNGAASSSLRTHVYHQPIHTSAPGSRPVGNISHSP 141
            |::::::    :..|...||         .||.....:|            ||.::.:|   |||
  Fly   115 EYINNQT----VGISRSAPG---------AGNPRLQPNL------------APQAKSLG---HSP 151

Mouse   142 KMAQPRMEPSLHTKIYDGPRLTQDHLSQGHCSRKCDRRAEGDSAPERK------LSPLISSLPSP 200
            ..|.....|:..:.....|...|.:..|   .|......:.|:.|...      ..|:.:.:||.
  Fly   152 SSASSAAGPTAASATTSLPGQQQHYQQQ---QRPPTYVKQADNKPPYNGRGGYPGQPMKNDIPSS 213

Mouse   201 ---VPPLSPVHSRLQGTSKAHSSGVSSKSCCVAKSSKDLVAKAQDKETPHDGLVAVTSLGSAPPQ 262
               .||..|..:   .:|.::||.|::.:     ||              .|:.|.|.||
  Fly   214 SGMAPPRGPPRT---SSSNSNSSSVTNNA-----SS--------------GGVPASTPLG----- 251

Mouse   263 PPCQTFPP---------PPLP---SKSAAMQQKPTAYVRPMDGQDQAPSESPELKL--------- 306
            ||..|..|         ||.|   :.:......|.|..||..||...|.|....|:
  Fly   252 PPLSTQMPNGREKSFLGPPAPALHNGTGGRFVPPAASKRPGVGQQPPPPEKDVNKIISDIANIFT 316

Mouse   307 --PL------------EDY----------------GQQSFEKPDLKVPAKAKLTR-----LRMPS 336
              ||            |:|                ...|.|...|..|..|.:|.     :..|.
  Fly   317 VQPLTLIAATPHAPTRENYNLLAPNRQKYAMDIPSSPPSAEPSSLMTPLFAPITSPIAPLVTTPP 381

Mouse   337 QSVEQPYSNEVH---CVEEILKEMTHSWPPPLTAIHTPSTAEPSRFPFPTKDPLHVSPATQSQKQ 398
            |:.:.|......   ...|.|..: |..||.:     |..|.....|.|.|
  Fly   382 QASQMPLGGATSGTILAGEALAPL-HQLPPTM-----PKAASGVTSPGPVK-------------- 426

Mouse   399 YDTPSKTHPNP--QQGTSMLEDDLQLSDSEDSDTEQATEKPPSPPAPPSAPQTLPEPVASAHSSS 461
               |.||..|.  ::..|.||:||:||:|||...::                       ...|..
  Fly   427 ---PLKTEKNHSLEKQDSCLENDLELSESEDEQRKK-----------------------EGRSGG 465

Mouse   462 GESESSESDSSSDSESESSSSDS-------------------------------EEEEENEPLET 495
            ..|.||||| ||:|.|||||.:.                               :::..::||.:
  Fly   466 NSSNSSESD-SSESGSESSSKNDLQHHPNHQQHHHQLQQQQQQQQATMQQQQVLQQQHRSQPLTS 529

Mouse   496 RAPE------------------------------------------------------------- 499
            ...:
  Fly   530 NGAQNKKFRHEIIARGSNTITGLLSSSGFGSGGNVGPAGVNSNAVVGTGSGSGGTLSSGGSSSNK 594

Mouse   500 -PEPPTTNKWQLDNWLTK-VNQPS------------VP--LDGRGSTESPQ--------WRQESK 540
             |.|..:|||.|..:..| .||.:            ||  |.| |:...|:        .:.|..
  Fly   595 TPSPTESNKWNLSRFFHKPANQTNSESVSPGNVSMKVPGILPG-GAQIIPESIDVTTAIVKNEKN 658

Mouse   541 GVAEGSSDQQHPDSKDPL-----------------------------PK---------------- 560
            .:|....:::..|.:..|                             ||
  Fly   659 DMAMEEGEEEDDDEEQQLRYGGGLSVTPVAVKKEAIDAVSEMALGAIPKTQIKRESAETLLSARL 723

Mouse   561 ---------------SSSKTLRGPSEGPQPGK------RGCPKS--------PAQ-QEPPPRQTV 595
                           |||.:..|....|.||.      .|.|.:        |.| |:.||..:|
  Fly   724 SDSGTSASGSSSSSSSSSDSAMGGEVVPMPGPGETLQLPGVPAAITTVMRVQPTQSQKAPPSNSV 788

Mouse   596 --------------GSKQPRKPAKGSGQAEPQASSQAESEVGPLPYG-------SKEQTSKDRPK 639
                          ..|:|||  |.:..:.|...|..:.|..|...|       .:.|.:.|..|
  Fly   789 TLTPILPLPTSPKQRQKKPRK--KKAITSAPILDSSDDDEPPPKHPGLDHTAVSVQTQPATDTVK 851

Mouse   640 VKTKGRPR-----------AVGSREPKPEVPAPTPQAAVPRPKPPVPTP-----SEKRKHKSSTA 688
             |.:||||           :..|.....:...||..||   .||...||     :.||:|.|.::
  Fly   852 -KGRGRPRKQQQSGGSGNLSSASAGSSSQTKGPTLTAA---KKPLAKTPLAMSRARKREHSSQSS 912

Mouse   689 -----PSKAPSAPQ-------PPKDSAGDRNPEHSALVSLTQSQGPSHSSRGSSGSVRT--SGCR 739
                 |:|..:.||       |..::||..:.:..: .|..:|...|.||..||....|  :.||
  Fly   913 SNGNTPTKKVATPQLVAAPLKPTSNTAGSSSSDEDS-SSSAESSSKSSSSSSSSDDTETQNTNCR 976

Mouse   740 ------------QAVIAQGD--------------------------------------------- 747
                        :|::..|.
  Fly   977 IVKLNKTGAVQKKALLGSGSSSPSSSGSEAEDQTTRSQVGSGQALAQQLPPYKQLPISQHSQHLS 1041

Mouse   748 ---------GC---------------------------KDKL---------------------LL 755
                     ||                           |:|:                     ::
  Fly  1042 SSDCSSSSGGCTAVCSSSSGEEDEGRREKERERKPKSDKNKINTLTRIFNPKEGGAKKQGQVVIV 1106

Mouse   756 PLRDTK-----------------------------------------LLSPLRDSPPP-TSLVVK 778
            .|::.:                                         |.||.|.:.|. |||:.|
  Fly  1107 DLQEEQQQGKLDAAAQPSAPQAPPAAPAAIMAKPRMTPTQQQQLGAGLASPARTTTPHLTSLICK 1171

Mouse   779 ITLDLLTR---------------------------IPQPLG-----------KGSRPRKAEDKQL 805
            |.|..|:|                           :..|.|           |...|.|.| .:|
  Fly  1172 IDLSKLSRERIMRLKKLTPAQQNGHLTPKDQATNAVHVPNGYAGDTNPAAKVKHEHPVKPE-PEL 1235

Mouse   806 SAGKKQDSETKSCDSSSRVTKKRKGDPEKEHSNKRHK-----------LDKSQTASSSSSHTESS 859
            .||.:...:..:.....::.::|..|.|:|...:|.:           ..:.:::|||||..:..
  Fly  1236 DAGYEAKFKPGNVKQEFQLKQERDRDRERERERERERERDREREQPPGRRRKRSSSSSSSPYKEK 1300

Mouse   860 RTKAPRSSSENSRKEMLP-----PAS----------------------ASSVSSSSSSQKPSRPA 897
            :.|..::......||:||     |::                      |::|....|:...| |.
  Fly  1301 KRKKEKADQLQMGKELLPVPVLLPSNNHERMPNHDRLSYDKLQLLHEDAAAVIGDVSAPNGS-PT 1364

Mouse   898 QK----RPRPDED-------TCSQ----EPPRSASSTKSSSTDPPAPKHRKVQA----RGSEHKG 943
            :|    .|.|...       ||::    .||   |:|.:|:..||.|..|.:..    |..||
  Fly  1365 KKLLAMSPLPPPPTVTVAPATCNEAVQTTPP---SATATSAIAPPVPATRLIYRSYFDRDVEH-- 1424

Mouse   944 SSGDAANAANPFPVPSLPNGNAKPGKPQVKSDRQQADFHMKEAKKLKCKAETMVDKAGKAFKYLE 1008
                          ||              .|.::.:..::||...|..|:...|...:...|||
  Fly  1425 --------------PS--------------DDPRKNNQFLQEAINRKHAADLERDSFNQVTLYLE 1461

Mouse  1009 AVLSFIECGMASESESSAKSAYAVYSETIDLIRYVMSLKCFSDNTMPAQEKI-----------FA 1062
            ||:.|:....|.|..||.::...:|.:|:.||:::      |....|.|::.           .|
  Fly  1462 AVVYFLLTADAMERCSSEQATNTMYKDTLSLIKFI------STKFRPYQQQSTTNIQHETHNKVA 1520

Mouse  1063 VLCLRCQSLLNMAMFRCKKDTVMKYSRTLSEHFK-STSKVAQAPSPCTARSTGVPSPLSPMPSPA 1126
            :|.||||||:::.:::.::........:|::.|: ....:|...:|.:.             ||:
  Fly  1521 ILSLRCQSLISLKLYKLRRKDCRAIINSLTDFFRVGRGDIANGNTPSSI-------------SPS 1572

Mouse  1127 SSVGSQSSAGSS-MGSVGVTATVSTPVSIQNMTSSYVTITSHVLTAFSLWEQAEALTRKNK--EF 1188
            :|||||.|..:: .|.:       .|..|.||........|::.:|..||:||:.|.|...  :|
  Fly  1573 NSVGSQGSGSNTPPGRI-------VPPDIHNMLCKQNEFLSYLNSAHELWDQADRLVRTGNHIDF 1630

Mouse  1189 FAQLSTKVRVLALNSSLVDLVHYTRQGLQRLKQSPKGP 1226
            ..:|..:...|.|:|::.::..|.:.||:.|:.:...|
  Fly  1631 IRELDHENGPLTLHSTMHEVFRYVQAGLKTLRDAVSHP 1668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aff1	NP_001074267.1	AF-4	17..1221	CDD:282905	340/1784 (19%)
lilli	NP_001137775.1	AF-4	<1435..1662	CDD:282905	63/252 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837793
Domainoid	1	1.000	131	1.000	Domainoid score	I5113
eggNOG	1	0.900	-	-		E1_28IRS
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	167	1.000	Inparanoid score	I4158
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001371
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10528
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4465
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.010