Protein Alignment apg-1 and AP-2alpha

DIOPT Version :10

• Sequence 1: NP_740937.1
• Gene: apg-1 / 173304
• WormBaseID: WBGene00000158
• Length: 829
• Species: Caenorhabditis elegans
• Sequence 2: NP_995607.1
• Gene: AP-2alpha / 33211
• FlyBaseID: FBgn0264855
• Length: 952
• Species: Drosophila melanogaster
• Alignment Length: 834
• Identity: 226/834 - (27%)
• Similarity: 399/834 - (47%)
• Gaps: 116/834 - (13%)

 Worm    49 VDRESANIRESFRDD---DSPWKCRNIAKLLYIHMLGYPAHFGQMECMKLVAHPRFTDKRIGYLG 110
            :::|.||||..|:.|   |...|.:.:.|||:|.:||:...||.||.:.|::..::::|:||||.
  Fly    44 INKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYSEKQIGYLF 108

 Worm   111 AMLLLDERSEVHMLVTNSLKNDLTCSTQFVSGLALCTLGSICSAEMCRDLANEVEKIIKQNNA-- 173
            ..:|::..|::..|:..|:||||.........|||..:.:|.|.:|....:||:.|::...:.
  Fly   109 ISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIPKLLVSGDTMD 173

 Worm   174 YLKKKAALCAFRIVRKVPELMEVFIP----CTR--SLLGEKNHGVLMGATTLVTEMCEKSPDVLN 232
            .:|:.||||..|:.|..|::    ||    .:|  .||.:::.||:..||:|:..:.:::||
  Fly   174 VVKQSAALCLLRLFRSSPDI----IPGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKRNPD--- 231

 Worm   233 HFKKLVPNLVRILKNLLMSGYSPEHDVT--GISDPFLQVKILRLLRVLGKDDVRVTEE------M 289
            .:|..|...|..|..::.:.|:...|.|  .:..|:|.||:||||:....    ||||      :
  Fly   232 EYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNP----VTEEAGVRARL 292

 Worm   290 NDILAQVATNTETA--------KNVGNAILYETVLTIMEIKSESGLRILAVNILGRFLLNTDKNI 346
            |:.|..:....:..        .|..||:|:|.:..|:...||..|.:.|.|.||:||.|.:.|:
  Fly   293 NETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQFLSNRETNL 357

 Worm   347 RYVALNTL--LKTVHVDYQAVQRHRNVVVECLK-DPDISIRKRAMELCFALMNRTNIAIMTKEVL 408
            ||:||.::  |.|....::.|::|:.||:..:| :.|:|:|:.|::|.:|:.:|.|...:.:|:|
  Fly   358 RYLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEIVQEML 422

 Worm   409 IFLETADAEFKSECASRMYIATERYSPNHEWHLDTMITVLRLAGKYVPDEVVSCMIQMISANEQL 473
            .:|||||...:.|...::.|..|:|:.::.|::|.::.::|:||.||.:||...:||::...|::
  Fly   423 NYLETADYSIREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVWYRVIQIVINREEV 487

 Worm   474 QSYAVSQLYHAAQKDAINAQPLLQVAFWTIGEFGDLLLQPTDVDSTPISENDVVGVFESVLPSA- 537
            |.||...::.|.|..|.: :.:::|..:.:||||:|:  ..|..|.|:       |...:|.|.
  Fly   488 QGYAAKTVFEALQAPACH-ENMVKVGGYILGEFGNLI--AGDSRSAPL-------VQFKLLHSKY 542

 Worm   538 -LTSLWTKCYGVTALAKLGTRFQSTGDRIGALVRM--NQAHIQLELQQRSVEF---NVILNLGDL 596
             |.|..|:...::...|....|......|..:.|.  |......|||||:.|:   :::.:. |:
  Fly   543 HLCSPMTRALLLSTYIKFINLFPEIRTNIQDVFRQHSNLRSADAELQQRASEYLQLSIVAST-DV 606

 Worm   597 RDGLLERMPVITHNS------LNAAAPSMIDEEVSAESGAPVVTNGDLLGDLNLGGGGSTNPSND 655
            ...:||.||......      |....|..:.|....||.:|.........:..:....|...:::
  Fly   607 LATVLEEMPSFPERESSILAVLKKKKPGRVPENEIRESKSPAPLTSAAQNNALVNNSHSKLNNSN 671

 Worm   656 YSSDLLGV------GVGSGAASAQAPPPPPPPTSNSNILDIFGDTPSSNAAGGFDFGMAAPAKEP 714
            .::||||:      .:|||:            .|||.::|:.||...||:...         ...
  Fly   672 ANTDLLGLSTPPSNNIGSGS------------NSNSTLIDVLGDMYGSNSNNN---------SSA 715

 Worm   715 TY--QPVIAINKGGI----EVQLQVIETWKNEKARLRMTAYNYTPRTLSNYNFFAAVTKTFEIAL 773
            .|  :..:..|.|.:    .:|:.|...::....||.:...|.|...|:|:|  ..:..:.|.||
  Fly   716 VYNTKKFLFKNNGVLFENEMLQIGVKSEFRQNLGRLGLFYGNKTQVPLTNFN--PVLQWSAEDAL 778

 Worm   774 E-----PASSPNIDPNEHTTQFMTIT-----RKAPNTTARMRTKISYIVDGTEQ 817
            :     ....|.::......|.:|..     ..||.      .:||:..:||:|
  Fly   779 KLNVQMKVVEPTLEAGAQIQQLLTAECIEDYADAPT------IEISFRYNGTQQ 826

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
apg-1	NP_740937.1	Adaptin_N	45..595	CDD:396262	174/582 (30%)
		Alpha_adaptinC2	721..827	CDD:197886	24/111 (22%)
AP-2alpha	NP_995607.1	Adaptin_N	40..603	CDD:396262	174/579 (30%)
		Alpha_adaptinC2	730..839	CDD:197886	22/105 (21%)
		Alpha_adaptin_C	839..947	CDD:426707