DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment apg-1 and AP-2alpha

DIOPT Version :9

Sequence 1:	NP_740937.1	Gene:	apg-1 / 173304	WormBaseID:	WBGene00000158	Length:	829	Species:	Caenorhabditis elegans
Sequence 2:	NP_995607.1	Gene:	AP-2alpha / 33211	FlyBaseID:	FBgn0264855	Length:	952	Species:	Drosophila melanogaster

Alignment Length:	834	Identity:	226/834 - (27%)
Similarity:	399/834 - (47%)	Gaps:	116/834 - (13%)

- Green bases have known domain annotations that are detailed below.

Worm    49 VDRESANIRESFRDD---DSPWKCRNIAKLLYIHMLGYPAHFGQMECMKLVAHPRFTDKRIGYLG 110
            :::|.||||..|:.|   |...|.:.:.|||:|.:||:...||.||.:.|::..::::|:||||.
  Fly    44 INKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYSEKQIGYLF 108

Worm   111 AMLLLDERSEVHMLVTNSLKNDLTCSTQFVSGLALCTLGSICSAEMCRDLANEVEKIIKQNNA-- 173
            ..:|::..|::..|:..|:||||.........|||..:.:|.|.:|....:||:.|::...:.
  Fly   109 ISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIPKLLVSGDTMD 173

Worm   174 YLKKKAALCAFRIVRKVPELMEVFIP----CTR--SLLGEKNHGVLMGATTLVTEMCEKSPDVLN 232
            .:|:.||||..|:.|..|::    ||    .:|  .||.:::.||:..||:|:..:.:::||
  Fly   174 VVKQSAALCLLRLFRSSPDI----IPGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKRNPD--- 231

Worm   233 HFKKLVPNLVRILKNLLMSGYSPEHDVT--GISDPFLQVKILRLLRVLGKDDVRVTEE------M 289
            .:|..|...|..|..::.:.|:...|.|  .:..|:|.||:||||:....    ||||      :
  Fly   232 EYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNP----VTEEAGVRARL 292

Worm   290 NDILAQVATNTETA--------KNVGNAILYETVLTIMEIKSESGLRILAVNILGRFLLNTDKNI 346
            |:.|..:....:..        .|..||:|:|.:..|:...||..|.:.|.|.||:||.|.:.|:
  Fly   293 NETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQFLSNRETNL 357

Worm   347 RYVALNTL--LKTVHVDYQAVQRHRNVVVECLK-DPDISIRKRAMELCFALMNRTNIAIMTKEVL 408
            ||:||.::  |.|....::.|::|:.||:..:| :.|:|:|:.|::|.:|:.:|.|...:.:|:|
  Fly   358 RYLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEIVQEML 422

Worm   409 IFLETADAEFKSECASRMYIATERYSPNHEWHLDTMITVLRLAGKYVPDEVVSCMIQMISANEQL 473
            .:|||||...:.|...::.|..|:|:.::.|::|.::.::|:||.||.:||...:||::...|::
  Fly   423 NYLETADYSIREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVWYRVIQIVINREEV 487

Worm   474 QSYAVSQLYHAAQKDAINAQPLLQVAFWTIGEFGDLLLQPTDVDSTPISENDVVGVFESVLPSA- 537
            |.||...::.|.|..|.: :.:::|..:.:||||:|:  ..|..|.|:       |...:|.|.
  Fly   488 QGYAAKTVFEALQAPACH-ENMVKVGGYILGEFGNLI--AGDSRSAPL-------VQFKLLHSKY 542

Worm   538 -LTSLWTKCYGVTALAKLGTRFQSTGDRIGALVRM--NQAHIQLELQQRSVEF---NVILNLGDL 596
             |.|..|:...::...|....|......|..:.|.  |......|||||:.|:   :::.:. |:
  Fly   543 HLCSPMTRALLLSTYIKFINLFPEIRTNIQDVFRQHSNLRSADAELQQRASEYLQLSIVAST-DV 606

Worm   597 RDGLLERMPVITHNS------LNAAAPSMIDEEVSAESGAPVVTNGDLLGDLNLGGGGSTNPSND 655
            ...:||.||......      |....|..:.|....||.:|.........:..:....|...:::
  Fly   607 LATVLEEMPSFPERESSILAVLKKKKPGRVPENEIRESKSPAPLTSAAQNNALVNNSHSKLNNSN 671

Worm   656 YSSDLLGV------GVGSGAASAQAPPPPPPPTSNSNILDIFGDTPSSNAAGGFDFGMAAPAKEP 714
            .::||||:      .:|||:            .|||.::|:.||...||:...         ...
  Fly   672 ANTDLLGLSTPPSNNIGSGS------------NSNSTLIDVLGDMYGSNSNNN---------SSA 715

Worm   715 TY--QPVIAINKGGI----EVQLQVIETWKNEKARLRMTAYNYTPRTLSNYNFFAAVTKTFEIAL 773
            .|  :..:..|.|.:    .:|:.|...::....||.:...|.|...|:|:|  ..:..:.|.||
  Fly   716 VYNTKKFLFKNNGVLFENEMLQIGVKSEFRQNLGRLGLFYGNKTQVPLTNFN--PVLQWSAEDAL 778

Worm   774 E-----PASSPNIDPNEHTTQFMTIT-----RKAPNTTARMRTKISYIVDGTEQ 817
            :     ....|.::......|.:|..     ..||.      .:||:..:||:|
  Fly   779 KLNVQMKVVEPTLEAGAQIQQLLTAECIEDYADAPT------IEISFRYNGTQQ 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
apg-1	NP_740937.1	Adaptin_N	45..595	CDD:279882	174/582 (30%)
apg-1	NP_740937.1	Alpha_adaptinC2	721..827	CDD:197886	24/111 (22%)
AP-2alpha	NP_995607.1	Adaptin_N	40..598	CDD:279882	174/574 (30%)
		Alpha_adaptinC2	730..839	CDD:197886	22/105 (21%)
		Alpha_adaptin_C	839..947	CDD:280460
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53727
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820