DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Met and PlexA

DIOPT Version :9

Sequence 1:NP_032617.2 Gene:Met / 17295 MGIID:96969 Length:1379 Species:Mus musculus
Sequence 2:NP_524637.2 Gene:PlexA / 43832 FlyBaseID:FBgn0025741 Length:1945 Species:Drosophila melanogaster


Alignment Length:1784 Identity:355/1784 - (19%)
Similarity:590/1784 - (33%) Gaps:662/1784 - (37%)


- Green bases have known domain annotations that are detailed below.


Mouse    29 ALVKSEMNVNMKYQLPNFTA-ETPIQNVVLH--GHHIYLGATNYIYVLNDKDLQKVSEFKTGPVL 90
            |.:|:..|:|.  .:.|..| :|.:.::::.  ...:::|..|.:|.|: .||:.....||||..
  Fly    53 APIKNAKNLNS--TITNVAAFDTKLNHLLVDTITGRVFVGGVNRLYQLS-PDLELSETVKTGPQN 114

Mouse    91 EHPDCLPCRDCSSKANSSGGVWKDNINMALLVDTYYDDQLISCGSVNRGTCQRHVLPPDNSADIQ 155
            :..:| ...||...|..|.   .||.|..||:|. ...:||:|||:.:|||....|  .|.:.|:
  Fly   115 DSVEC-SILDCPLNAVRSP---TDNYNKVLLIDR-ATSRLIACGSLFQGTCTVRNL--QNVSIIE 172

Mouse   156 SEVHCMFSPEEESGQCPDCVVSALGAKVLLSEKDRFIN-----------FFVGNTINSSYPPGYS 209
            .||             ||.||    |....|....||.           .:||.|..::.|....
  Fly   173 HEV-------------PDAVV----ANDANSSTVAFIAPGPPQHPVTNVMYVGVTYTNNSPYRSE 220

Mouse   210 LHSISVRRLKET---QDGFKFLTDQSYIDVLPEFQDSYPIKYIHAFESNHFIYFLTVQ---KETL 268
            :.:::.|.|::|   |.....:|..:...:....:::|.:.|::.|.|..|.||||.|   ....
  Fly   221 IPAVASRSLEKTKMFQIASSAVTTGTRTFINSYARETYFVNYVYGFSSERFSYFLTTQLKHSHHS 285

Mouse   269 DAQTFHTRIIRFCSVDSGLHSYMEMPLECILTEKRRKRSTREEVFNILQAAYVSKPGANLAKQIG 333
            ..:.:.|:::|.|..||..:||.|:|:|||...:...:      ||::||.::.||.::||:.:|
  Fly   286 SPKEYITKLVRICQEDSNYYSYTEIPVECISDAQGGTK------FNLVQAGFLGKPSSDLAQSLG 344

Mouse   334 ASPSDDILFGVFAQSKPDSAEPVNRSAVCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFN 398
            .|..||:||.||  ||.:...|.|.||:|.:.:|.:...|.:                |.:.|||
  Fly   345 ISIQDDVLFAVF--SKGEGNTPTNNSALCIYSLKSIRRKFMQ----------------NIKSCFN 391

Mouse   399 RTLLRN------SSGC-----EARSDEY-----------RTEFTTALQRVDLFMGRLNQVLLTSI 441
            .:.:|.      |..|     :...:::           .|..|:.  .|.:|..:|..|..||.
  Fly   392 GSGMRGLDFISPSMPCVLTKLQTIGEDFCGLDVNSPLGGETPITSV--PVAMFNTKLTSVAATST 454

Mouse   442 STFIKGDLTIANLGTSEGRFMQVVLSRTAHLTPHVNFLLDSHPVSPEVIVEHP-SNQNGYTLVVT 505
            |.:     |:..:|||:|...:||:..::....:.:|.:|   :..|:..:.. .|||.|..|::
  Fly   455 SGY-----TVVFVGTSDGFLKKVVIESSSIANEYASFAVD---LGSEINRDMQFDNQNLYIYVMS 511

Mouse   506 GKKITKIPLNGLGCGHFQSCSQCLSA--PYFIQCGWC---------------------------- 540
            ..|::|:.:  ..|..:::|..||.|  ||   ||||                            
  Fly   512 KTKVSKVKV--FDCSDYKTCGDCLGARDPY---CGWCSLENKCSPRSNCQDDANDPLYWVSYKTG 571

Mouse   541 ----------------------------------------------------------------- 540
                                                                             
  Fly   572 KCTTITSVVPHQLQRTTARTLELIIDHLPQLKENLICAFTTEDKALFTNATKKRNGVNCTTPRTD 636

Mouse   541 --------------------------------------HNQCVRFDE------------------ 549
                                                  |:.|.|...                  
  Fly   637 MLPQIEQGKHHFTAKLSVRTRNGPDLVSTDFTFFDCSTHSSCTRCVSSEFPCDWCVEAHRCTHDT 701

Mouse   550 --------------------------CPS--------------GT-------------------- 554
                                      ||:              ||                    
  Fly   702 AENCRNDILVTGVSRIGPSYRSGPGFCPTINATGDGSEVLVAGGTSKSIKVKVHIIGQFIVQTRF 766

Mouse   555 ----------------------------------------------------------------- 554
                                                                             
  Fly   767 VCQFNIEGRVTSLNAQLLGDTIYCDSMEFQYTSRSPNLTATFAVIWGGSKPLDNPHNIHVVIYRC 831

Mouse   555 -------------------------------------------W--TQEIC-LPAVYKVFPTSAP 573
                                                       |  ..||| .|.::...|.:.|
  Fly   832 REMADSCGICLALSEKYNCGWCSSTNTCEVEEQCNKNKEGKTDWLNRSEICPNPEIHTFQPKTGP 896

Mouse   574 LEGGTVLTICGWDFGFRKNNKFDLRKTKVLLGNESCTLTLSESTTNTLKCTV---GPAMSEHFNV 635
            .||||.:||.|.:.|   .|..|:.....:.|............|..:.|||   |..|..:..:
  Fly   897 WEGGTNITIRGINLG---KNYNDIYSGVRIAGINCMPFPQFYIDTKQIVCTVDSPGEQMYRNGKI 958

Mouse   636 SVIISNSRETTQYSAFSYVDPVITSISPRYGPQAGGTLLTLTGKYLNSGNSRHISIGGK-TCTLK 699
            .|.|.:.|..:: ..:.:|||.|...:|::||.:|||.:.:|||:||:|:....||... .|.:.
  Fly   959 VVQIGDYRGESK-EDYEFVDPKILDFNPKFGPTSGGTEIHITGKHLNAGSRIQASINDHLPCKIL 1022

Mouse   700 SVSDSILECYTPAQTTSDEFPVKLKIDLANRETS--SFSYREDPVVY--------EIHPTKSFIS 754
            |...|...|.|.|.....|..:|:..|...||.:  :|.|..||.|.        :|...|...:
  Fly  1023 STDSSQAICRTSASPGIIEGRLKMSFDNGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPKGIPA 1087

Mouse   755 GGSTITGIGKTLNSVSLPKLVIDVHEVGVNYTVACQHRSNSEIICCTTPSL----KQLGLQLPLK 815
            ||..|:..|....|:..|.:.:..:  |..|...|:.:|::|:. |.:|.:    ..:..:.|:.
  Fly  1088 GGIRISVTGTQFTSIQNPNIYVVYN--GEMYASPCRVQSDTEME-CASPVVDVDSHVIEAERPIL 1149

Mouse   816 TKAFFLLDGILSKHFDLTYVHNPVFEPFEKPVMISIGNENV-------VEIKGNNIDPEAVKGEV 873
            .:..||:|.:|... :|:.|||..||.:..|... |..|.|       :.|.|.|:|....:.:|
  Fly  1150 LEYGFLMDNVLRVQ-NLSKVHNNHFELYPNPEYF-IFEERVKYFKSEYLTINGRNLDRACKESDV 1212

Mouse   874 -LKVGNQSCESLHWHSGAVLCTVPSD------------LLKLNSELNIEWKQAVSSTVLGKVIVQ 925
             :|:||..|.........:.|..||:            ::::.:.|  |::..:.|.....:|:.
  Fly  1213 EVKIGNGFCNITSLSRQQLTCRPPSEATATKSMNGPEVIVRIGTSL--EYRIGILSYESSNIILD 1275

Mouse   926 PDQNFAGLIIGAVSISVVVLLLSGLFLWMRKRKHKDLGSELVRYDARVHTPHLDRLVSARSVSPT 990
            ..:|    :|.||..::|:|||..:.|.:..:|.....|.::| :.:.....|:..|:|      
  Fly  1276 WGEN----VIFAVIATIVILLLIFVALLVAYKKKSSESSRVLR-NMQEQMDILELRVAA------ 1329

Mouse   991 TEMVSNESVDYRATFPEDQFPNSSQNGACRQVQYPLTDLSPILTSGDSDISSPLL---------- 1045
                     :.:..|.|              :|..:|||:..||||    ..|.|          
  Fly  1330 ---------ECKEAFAE--------------LQTEMTDLTGDLTSG----GIPFLDYRSYAMKIL 1367

Mouse  1046 --QNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVK 1108
              .:..||.|....|||::..:.:.|        |.::|....|..::..||             
  Fly  1368 FPNHEDHIVLQWERPELLRKEKGLRI--------FGQLIMNKTFLLLFIRTL------------- 1411

Mouse  1109 SLNRITDIEEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKH------GDL-RNF 1166
            ..||...:.|               ..||.||:.:.|:|:      |.|...      ||| ...
  Fly  1412 ESNRYFSMRE---------------RVNVASLIMVTLQSK------LEYCTDILKTLLGDLIEKC 1455

Mouse  1167 IRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKE 1231
            |..::|                      .|..:.|..:....||...||..:..|  .::...:.
  Fly  1456 IEGKSH----------------------PKLLLRRTESVAEKMLSAWFTFLLYKF--LKECAGEP 1496

Mouse  1232 YYSVHNKTGAKL---PVKWMALE---SLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDI 1290
            .|.:......::   ||.....|   ||..:|...:|                    .|....::
  Fly  1497 LYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQS--------------------IDFRPMNV 1541

Mouse  1291 TIYLLQGRRLLQPEYCPDALYEVMLKCWHPKAEMRPSFSELVSRISSIFSTFIGEHYVHVNATYV 1355
            ...::|     ||.:|.:             .:|.||.:|.|| :..:....||:         |
  Fly  1542 YASIIQ-----QPIFCNN-------------LDMLPSHTENVS-VKVLDCDTIGQ---------V 1578

Mouse  1356 NVKCVAPYPSLLPS-----QDNIDGEGNT 1379
            ..||:......:||     :|::|.|..|
  Fly  1579 KEKCLETIYRNIPSSQRPRKDDLDLEWRT 1607

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MetNP_032617.2 Sema 25..515 CDD:387663 138/528 (26%)
PSI 518..560 CDD:214655 20/362 (6%)
IPT_plexin_repeat1 562..655 CDD:238585 23/95 (24%)
IPT_plexin_repeat2 656..739 CDD:238584 29/85 (34%)
IPT 741..836 CDD:387656 23/106 (22%)
IPT_PCSR 838..917 CDD:238337 20/98 (20%)
PTKc_Met_Ron 1080..1341 CDD:270649 46/273 (17%)
Interaction with RANBP9. /evidence=ECO:0000250 1210..1379 33/179 (18%)
Interaction with MUC20. /evidence=ECO:0000250 1318..1357 9/38 (24%)
PlexANP_524637.2 Sema_plexin_like 75..520 CDD:200497 131/503 (26%)
PSI 522..574 CDD:279745 11/54 (20%)
PSI 671..>699 CDD:279745 3/27 (11%)
PSI 830..883 CDD:279745 3/52 (6%)
IPT_plexin_repeat1 885..977 CDD:238585 23/95 (24%)
IPT_plexin_repeat2 978..1063 CDD:238584 28/84 (33%)
IPT 1078..1177 CDD:301692 26/102 (25%)
IPT_PCSR 1196..>1255 CDD:238337 12/58 (21%)
Plexin_cytopl 1353..1916 CDD:285529 67/369 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3610
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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