DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mep1b and Cubn2

DIOPT Version :10

Sequence 1:NP_032612.2 Gene:Mep1b / 17288 MGIID:96964 Length:704 Species:Mus musculus
Sequence 2:NP_729748.3 Gene:Cubn2 / 39334 FlyBaseID:FBgn0259140 Length:3613 Species:Drosophila melanogaster


Alignment Length:723 Identity:140/723 - (19%)
Similarity:241/723 - (33%) Gaps:246/723 - (34%)


- Green bases have known domain annotations that are detailed below.


Mouse    78 YVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWSGEANYISVFKGSGCWSSVGNIHAGKQELSIG 142
            ||||.::.:..:              |        :..||.:|.|.   |.||.|..|....|  
  Fly  2728 YVLEGNVTLTDR--------------C--------DREYIVIFSGQ---SEVGRICRGMAMNS-- 2765

Mouse   143 TNCDR-IATVQHEFLHALGFWHEQSR-ADRDDYVIIVWDRIQPGKEHNFNIYNDSVSDSLNVPYD 205
            |..:| .:|:         .:|.:|| |.:..:::..|..:..|             :::.:.:.
  Fly  2766 TLLERPFSTI---------LYHSESRLAQQSKFILQAWKSVSSG-------------NAIRIDHR 2808

Mouse   206 YTSVMHYSKTAFQNGTESTIVTRISEF--EDVIGQRMDFSDYDLLKLNQLY-----NCTSSLSFM 263
            .:..:..|.   :|..||.  .||.||  .|.:..|:.|       |.:::     ||::....:
  Fly  2809 PSPPVTISS---KNYLESK--QRIWEFVTNDGLSLRLHF-------LERIFIVSSPNCSTDRLTV 2861

Mouse   264 DSCD------FELENICG-------MIQS-------------SGDSADWQRV----SQVLSGPE- 297
            :..|      .|:.::||       ::.|             :||...:|.:    |.:|:|.| 
  Fly  2862 ERYDQTTEEYIEVTSLCGRQAANDILVPSARMRVIFQTNSNITGDGFSFQVIPSCDSVLLAGAEI 2926

Mouse   298 ---------SDHSKMGQCKDSGFFMHFNTSILNEGATAMLESRLLYPKRGFQCLEFYL--YNSGS 351
                     :...:...|..: |:.|.|..::   .:.....|   |...:.|...|.  |..|.
  Fly  2927 QTLASPSWAAFRGRQFNCSYT-FYAHDNHQVV---VSVRTRGR---PWASYACSRSYFEAYRRGD 2984

Mouse   352 GN----DQLNIYTREYTTGQQGGVLTLQRQIKEV-PIGSW-QLHYVTLQVTKKFRVVFEGLRGPG 410
            ||    :.:.....|:.....|.|     :::.| |:..| ::.|..:|....:...|. ||.| 
  Fly  2985 GNGVGEESIGRLCPEFEVKGNGRV-----RLRYVSPLSRWFEMQYQLIQCGGNYSTSFT-LRPP- 3042

Mouse   411 TSSGGLSIDDINLSETRCPHHIWHIQNFTQILGGQDTSVY-----------SPPFYSSKGYAFQI 464
                                     ||       :|:|||           :||     .:|..|
  Fly  3043 -------------------------QN-------EDSSVYAHNTLCEWRITAPP-----QHAVVI 3070

Mouse   465 ---YMDLRSSTNVG-----IY-FHLISGANDDQLQWPCPWQQATMTLLDQ--NPDIRQRMFNQRS 518
               |.|:.||.|.|     || .|::|.            :|.|..|...  ||:......|:..
  Fly  3071 EFKYFDMESSRNCGFDSLTIYRGHVVSE------------EQRTGLLCGNVTNPETIIVNSNEAL 3123

Mouse   519 ITTDPTMTSDNGSYFWDRPSKVGVTDVFPNGTQFSRGIGYGTTVFITRERLKSREFIKGDDIYIL 583
            |    .:|:|:.:.:....:.|..|   ||..:.     ....:.:.|..:..:        |::
  Fly  3124 I----VLTTDSSNSYRGFLASVRFT---PNCNEH-----VALDLEVPRMSVMRQ--------YVV 3168

Mouse   584 LTVEDISHLNSTSAVPDPVPTLAVH--NACSEVVCQNGGICVVQDGRAECKCPAGEDWW-YMGKR 645
            ...|.:..:...||.||...:|.|.  ....:|||:......:.|.    |...|::.. |.|..
  Fly  3169 NISESLLCIFQASAPPDYRISLEVRKLQLADDVVCRTCSYLEIHDS----KDVEGQNLGRYYGGT 3229

Mouse   646 CEKRGSTRDTV----------IIAVSSTVTV-FAVMLIITLVSVYCTRRKYRKKARAN---TAAM 696
            .....|.|..|          :||.:..... .:..||:.:|...|.:.:|  ..|.|   |..|
  Fly  3230 NGNEPSNRTKVFSSFSDMSFKLIATTGQAQKNISFELILQMVRTVCGQGEY--DLRLNETITLGM 3292

Mouse   697 TLENQHAF 704
            ..:|...|
  Fly  3293 QYDNSTRF 3300

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mep1bNP_032612.2 ZnMc 30..256 CDD:469599 36/186 (19%)
MAM 266..429 CDD:459878 36/210 (17%)
MATH 428..587 CDD:445786 35/180 (19%)
EGF_CA 609..647 CDD:238011 8/38 (21%)
Cubn2NP_729748.3 cubilin_NTD 38..141 CDD:412063
EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 290..328 CDD:214542
EGF_CA 330..374 CDD:214542
EGF 427..455 CDD:394967
EGF_CA 462..496 CDD:238011
CUB 503..619 CDD:238001
CUB 624..738 CDD:238001
CUB 745..854 CDD:238001
CUB 857..963 CDD:238001
CUB 1066..1179 CDD:238001
CUB 1185..1293 CDD:238001
CUB 1303..1406 CDD:238001
CUB 1411..1523 CDD:238001
CUB 1530..1648 CDD:238001
CUB 1754..1862 CDD:238001
CUB 1979..2091 CDD:238001
CUB 2210..2321 CDD:238001
CUB 2327..2441 CDD:238001
CUB 2688..2782 CDD:412131 19/89 (21%)
CUB 2810..2911 CDD:238001 21/112 (19%)
CUB 3029..3143 CDD:238001 34/168 (20%)
CUB 3169..3249 CDD:412131 18/83 (22%)
CUB 3499..3607 CDD:238001
Blue background indicates that the domain is not in the aligned region.

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