DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mep1b and CG42255

DIOPT Version :9

Sequence 1:	NP_032612.2	Gene:	Mep1b / 17288	MGIID:	96964	Length:	704	Species:	Mus musculus
Sequence 2:	NP_729748.3	Gene:	CG42255 / 39334	FlyBaseID:	FBgn0259140	Length:	3613	Species:	Drosophila melanogaster

Alignment Length:	723	Identity:	140/723 - (19%)
Similarity:	241/723 - (33%)	Gaps:	246/723 - (34%)

- Green bases have known domain annotations that are detailed below.

Mouse    78 YVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWSGEANYISVFKGSGCWSSVGNIHAGKQELSIG 142
            ||||.::.:..:              |        :..||.:|.|.   |.||.|..|....|
  Fly  2728 YVLEGNVTLTDR--------------C--------DREYIVIFSGQ---SEVGRICRGMAMNS-- 2765

Mouse   143 TNCDR-IATVQHEFLHALGFWHEQSR-ADRDDYVIIVWDRIQPGKEHNFNIYNDSVSDSLNVPYD 205
            |..:| .:|:         .:|.:|| |.:..:::..|..:..|             :::.:.:.
  Fly  2766 TLLERPFSTI---------LYHSESRLAQQSKFILQAWKSVSSG-------------NAIRIDHR 2808

Mouse   206 YTSVMHYSKTAFQNGTESTIVTRISEF--EDVIGQRMDFSDYDLLKLNQLY-----NCTSSLSFM 263
            .:..:..|.   :|..||.  .||.||  .|.:..|:.|       |.:::     ||::....:
  Fly  2809 PSPPVTISS---KNYLESK--QRIWEFVTNDGLSLRLHF-------LERIFIVSSPNCSTDRLTV 2861

Mouse   264 DSCD------FELENICG-------MIQS-------------SGDSADWQRV----SQVLSGPE- 297
            :..|      .|:.::||       ::.|             :||...:|.:    |.:|:|.|
  Fly  2862 ERYDQTTEEYIEVTSLCGRQAANDILVPSARMRVIFQTNSNITGDGFSFQVIPSCDSVLLAGAEI 2926

Mouse   298 ---------SDHSKMGQCKDSGFFMHFNTSILNEGATAMLESRLLYPKRGFQCLEFYL--YNSGS 351
                     :...:...|..: |:.|.|..::   .:.....|   |...:.|...|.  |..|.
  Fly  2927 QTLASPSWAAFRGRQFNCSYT-FYAHDNHQVV---VSVRTRGR---PWASYACSRSYFEAYRRGD 2984

Mouse   352 GN----DQLNIYTREYTTGQQGGVLTLQRQIKEV-PIGSW-QLHYVTLQVTKKFRVVFEGLRGPG 410
            ||    :.:.....|:.....|.|     :::.| |:..| ::.|..:|....:...|. ||.|
  Fly  2985 GNGVGEESIGRLCPEFEVKGNGRV-----RLRYVSPLSRWFEMQYQLIQCGGNYSTSFT-LRPP- 3042

Mouse   411 TSSGGLSIDDINLSETRCPHHIWHIQNFTQILGGQDTSVY-----------SPPFYSSKGYAFQI 464
                                     ||       :|:|||           :||     .:|..|
  Fly  3043 -------------------------QN-------EDSSVYAHNTLCEWRITAPP-----QHAVVI 3070

Mouse   465 ---YMDLRSSTNVG-----IY-FHLISGANDDQLQWPCPWQQATMTLLDQ--NPDIRQRMFNQRS 518
               |.|:.||.|.|     || .|::|.            :|.|..|...  ||:......|:..
  Fly  3071 EFKYFDMESSRNCGFDSLTIYRGHVVSE------------EQRTGLLCGNVTNPETIIVNSNEAL 3123

Mouse   519 ITTDPTMTSDNGSYFWDRPSKVGVTDVFPNGTQFSRGIGYGTTVFITRERLKSREFIKGDDIYIL 583
            |    .:|:|:.:.:....:.|..|   ||..:.     ....:.:.|..:..:        |::
  Fly  3124 I----VLTTDSSNSYRGFLASVRFT---PNCNEH-----VALDLEVPRMSVMRQ--------YVV 3168

Mouse   584 LTVEDISHLNSTSAVPDPVPTLAVH--NACSEVVCQNGGICVVQDGRAECKCPAGEDWW-YMGKR 645
            ...|.:..:...||.||...:|.|.  ....:|||:......:.|.    |...|::.. |.|..
  Fly  3169 NISESLLCIFQASAPPDYRISLEVRKLQLADDVVCRTCSYLEIHDS----KDVEGQNLGRYYGGT 3229

Mouse   646 CEKRGSTRDTV----------IIAVSSTVTV-FAVMLIITLVSVYCTRRKYRKKARAN---TAAM 696
            .....|.|..|          :||.:..... .:..||:.:|...|.:.:|  ..|.|   |..|
  Fly  3230 NGNEPSNRTKVFSSFSDMSFKLIATTGQAQKNISFELILQMVRTVCGQGEY--DLRLNETITLGM 3292

Mouse   697 TLENQHAF 704
            ..:|...|
  Fly  3293 QYDNSTRF 3300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mep1b	NP_032612.2	ZnMc	30..256	CDD:294052	36/186 (19%)
		Astacin	70..258	CDD:279708	38/188 (20%)
		MAM	266..430	CDD:279023	36/211 (17%)
		MAM	266..428	CDD:99706	36/209 (17%)
		MATH	428..587	CDD:295307	35/180 (19%)
		EGF_CA	609..647	CDD:238011	8/38 (21%)
CG42255	NP_729748.3	EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	290..328	CDD:214542
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:278437
		EGF_CA	462..496	CDD:238011
		CUB	503..619	CDD:238001
		CUB	624..738	CDD:238001
		CUB	745..854	CDD:238001
		CUB	857..963	CDD:238001
		CUB	1066..1179	CDD:238001
		CUB	1185..1293	CDD:238001
		CUB	1303..1406	CDD:238001
		CUB	1411..1523	CDD:238001
		CUB	1530..1648	CDD:238001
		CUB	1754..1862	CDD:238001
		CUB	1979..2091	CDD:238001
		CUB	2096..2193	CDD:294042
		CUB	2210..2321	CDD:238001
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:294042	19/89 (21%)
		CUB	2810..2911	CDD:238001	21/112 (19%)
		CUB	3029..3143	CDD:238001	34/168 (20%)
		CUB	3169..3249	CDD:294042	18/83 (22%)
		CUB	3499..3607	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900