DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mep1a and CG15253

DIOPT Version :9

Sequence 1:	NP_032611.2	Gene:	Mep1a / 17287	MGIID:	96963	Length:	760	Species:	Mus musculus
Sequence 2:	NP_609758.1	Gene:	CG15253 / 34916	FlyBaseID:	FBgn0028948	Length:	253	Species:	Drosophila melanogaster

Alignment Length:	271	Identity:	94/271 - (34%)
Similarity:	134/271 - (49%)	Gaps:	36/271 - (13%)

- Green bases have known domain annotations that are detailed below.

Mouse    11 FAIMLWIQPACLLSLIFSAHIAAVSIKHLLNGSDHDTDVGEQKDIFEINLAAGLNLFQGDILLP- 74
            ::|:|      ||.::.:...||.||:       .:||.         .|.||  ..:|| ::|
  Fly     4 YSILL------LLLVVVNVAWAAPSIR-------IETDP---------ELTAG--YIEGD-MVPS 43

Mouse    75 -RTRNAMRDPSSRWKLPIPYI-LADNLELNAKGAILHAFEMFRLKSCVDFKPYEGESSYI--IFQ 135
             .:||..|:.:.||...|.|. :...::...:..|:.|.:.....||:.||....:..|.  :..
  Fly    44 GSSRNIWRNETYRWPNRIIYYHINSYIDEEHRNHIVSAIQKIESISCLTFKEATTDQKYYVNVTS 108

Mouse   136 KLSGCWSMIG----DQQVG-QNISIGEGCDFKATIEHEILHALGFFHEQSRTDRDDYVNIWWDQI 195
            :..||:|.||    .||:. ||..||.||....||.||.||||||||:||..||||||.|..:.|
  Fly   109 EEGGCFSYIGYLNRVQQLNLQNNEIGVGCFRLYTIVHEFLHALGFFHQQSAADRDDYVQIVEENI 173

Mouse   196 ITDYEHNFNTYDDNTITDLNTPYDYESLMHYGPFSFNKNESIPTITTKIPEFNTIIGQLPDFSAI 260
            ....|.||:.|.:.|:.|....|||.|:|||||::|:||.. .||.........:|||..:.|..
  Fly   174 TEGMEFNFDKYTEETVNDFGEKYDYGSVMHYGPYAFSKNGE-RTILALEEGKEDVIGQRLELSET 237

Mouse   261 DLIRLNRMYNC 271
            |:.:||.:|.|
  Fly   238 DIRKLNAIYKC 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mep1a	NP_032611.2	ZnMc	46..271	CDD:381785	85/234 (36%)
		MAM	281..444	CDD:366209
		MATH	443..607	CDD:351761
		EGF	688..722	CDD:333761
CG15253	NP_609758.1	Astacin	55..250	CDD:279708	75/195 (38%)
CG15253	NP_609758.1	ZnMc_astacin_like	59..246	CDD:239807	71/187 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910