DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Men1 and Mnn1

DIOPT Version :9

Sequence 1:	NP_001161960.1	Gene:	Men1 / 17283	MGIID:	1316736	Length:	617	Species:	Mus musculus
Sequence 2:	NP_001036342.1	Gene:	Mnn1 / 33991	FlyBaseID:	FBgn0031885	Length:	763	Species:	Drosophila melanogaster

Alignment Length:	721	Identity:	278/721 - (38%)
Similarity:	374/721 - (51%)	Gaps:	148/721 - (20%)

- Green bases have known domain annotations that are detailed below.

Mouse     3 PPAAMGLKAAQKTLFPLRSIDDVVRLFAAEL-GREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPE 66
            |.|..|:..|  :||||:|..||:.||...| ...||||.|||:|:|::|..|........
  Fly    12 PMALNGVIDA--SLFPLKSTADVINLFRRALTSGIEPDLTLLSIVVGYIELSLTTGEAAAQ---- 70

Mouse    67 LTFQPSPAPDPPGGLTY---------------FPVADLSIIAALYARFTAQIRGAVDLSLYPREG 116
             ..|.:.|....|.::.               |||....:||.||.:|.. |...|:   .|:..
  Fly    71 -AAQAAAAAVAAGDISQATTGGNDIIMGNSVPFPVVTHELIAGLYKKFQT-ILSVVE---KPKPH 130

Mouse   117 GVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHL 181
            ..::||::|||||||||||.||.:|||||:|:|:|:::|.|||..|||.|||..||.||.:||.|
  Fly   131 RQATREVIKKVSDVIWNSLIRSSYKDRAHLQNLYSYLSGNKLDCFGVALAVVAGCQLLGYKDVRL 195

Mouse   182 ALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMV 246
            |:||||||||||....:|.||||||||:||:|||.:..|:...|||||.|..:.|:|.||||.:.
  Fly   196 AISEDHAWVVFGQKRVETIEVTWHGKGSEDKRGQDIRPGIESGSWLYLGGLAVVCERGMEVAAIC 260

Mouse   247 CAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKG 311
            .|:|.|:..::|.:|:.:|||:|||||||||||:|||||||.|.:|||:..|........||.:.
  Fly   261 AALNISLTSNSDCVEVAELQQQLLWLLYDLGHLKRYPMALGTLGELEEIHRTHPSISCEQLYREA 325

Mouse   312 IASAKTYYQDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNY-CREDEEIYKEFFEVAN 375
            |.||:|:|::.|:|||.|...|:.|....|:|..|||:.|.||:.|.| ||:|||||||..::||
  Fly   326 IESARTHYRNHHVYPYTYQGNYYNRLLKYRDAFAAWANAADVIRLYTYQCRDDEEIYKELLDIAN 390

Mouse   376 DVIPNLLKEAASLLETGEERTGEQAQGTQGQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHV 440
            ::||.::|         .|.:|..|:      |.|:|.|.||:|||||||||:|||.|.||:||:
  Fly   391 ELIPYVMK---------TESSGHSAR------SILRDSEVFANLLRFYDGICQWEEDSLTPILHI 440

Mouse   441 GWATFLVQSLGRFEGQVRQKVHI-----------------VSREA-EAAEAEEPWGDEAREGRRR 487
            |||..||.::.:|:..:|.:|.|                 ..:|| ||.|::|..|.||.||...
  Fly   441 GWAKPLVNNITKFDYDIRSQVVIKLPEDLEAEQAKAELARAEQEAKEAKESKEAAGSEAMEGNNN 505

Mouse   488 GPRRESKPEEPPPPKKPA--LDKGPGSGQS--------AGSGPP-----RKTSG----------- 526
              |..:|.|:....:.|.  .|.....|:.        .|.|.|     ::.||
  Fly   506 --RMATKEEKSKNSELPTTLADLTAACGEKILNPDFLLQGGGQPFADQKQQPSGGESDNPELHNN 568

Mouse   527 ------------------------TVPGTTRGG----------QEVGNAAQAPAPAASPPPEG-- 555
                                    |...||..|          .|..||.||.:........|
  Fly   569 NNNSNSNNNNNNHNADKKEAAATTTNATTTSNGSGTSVQLPVSSEANNAGQAQSQVQINDQLGKP 633

Mouse   556 -----------------------PVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQ 597
                                   ||:|..|:||||:|:||:|.|:|:.||.||:||||....|.:
  Fly   634 QHKEAKKEETSDDYDPFEIMLKRPVITLYSQKMKGLKDLLLAEKLNTHAISLQVTAQSVASRKVR 698

Mouse   598 KVSTPS 603
            .|...|
  Fly   699 GVEKHS 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men1	NP_001161960.1	Menin	8..615	CDD:282857	276/716 (39%)
Men1	NP_001161960.1	Menin	9..464	CDD:271218	218/488 (45%)
Mnn1	NP_001036342.1	Menin	17..464	CDD:271218	218/472 (46%)
Mnn1	NP_001036342.1	Menin	18..714	CDD:282857	275/715 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845979
Domainoid	1	1.000	403	1.000	Domainoid score	I729
eggNOG	1	0.900	-	-		E1_2CNB7
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7418
Inparanoid	1	1.050	452	1.000	Inparanoid score	I1593
Isobase	1	0.950	-	0	Normalized mean entropy	S6534
OMA	1	1.010	-	-		QHG49672
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006939
OrthoInspector	1	1.000	-	-		oto92653
orthoMCL	1	0.900	-	-		OOG6_108783
Panther	1	1.100	-	-	LDO	PTHR12693
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5242
SonicParanoid	1	1.000	-	-		X5031
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740