DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fyco1 and Sara

DIOPT Version :9

Sequence 1:	NP_001103723.2	Gene:	Fyco1 / 17281	MGIID:	107277	Length:	1437	Species:	Mus musculus
Sequence 2:	NP_524729.2	Gene:	Sara / 44263	FlyBaseID:	FBgn0026369	Length:	1343	Species:	Drosophila melanogaster

Alignment Length:	754	Identity:	134/754 - (17%)
Similarity:	256/754 - (33%)	Gaps:	210/754 - (27%)

- Green bases have known domain annotations that are detailed below.

Mouse   591 NMVDRNQLLEGKLQALQTDYKALQQREAAIQGSLASLEAEQASIRHLGNQMEASLLAV-KKAKET 654
            ::||.:|:|:....::..|       |...:.:.|:..|.....|.||:...||:..| ..|..:
  Fly     2 DLVDIDQVLDNLELSIAAD-------EQLSRNAAAAAAAGANPGRFLGDGASASISGVGAGAGVS 59

Mouse   655 MKAQVAEKEAALQSKESECQ---RLQEEADQCR-LQAEAQAQELRALENQCQQQIQ-----LIEV 710
            ..|.|....|:.:|.....|   .|.:..:..: ||.:||   |.:.:.|.:.:.:     ..|.
  Fly    60 GAAGVTPTPASGKSFVGVSQVFNSLDDYRENVKSLQVDAQ---LPSYDWQTEAEHEDDIHKFSEQ 121

Mouse   711 LSAEKGQ------QGLSLPQVNTDQLALSQAQLEIHQGEAQRLQNEVVDLQAKLQVALGDRDKLQ 769
            .|...||      :.|:....:|.....|......|..|                :|....|:..
  Fly   122 ASKNNGQTIVSSSESLTTSSCSTFSSGPSPVSNGSHSEE----------------LATPPEDEKT 170

Mouse   770 SQLGVAETVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGILQEESIYKAQKQEQELRALQA 834
            |::.|..   :|.....:|:|.:::     |              |::::....:.:|.:..|..
  Fly   171 SEVQVEP---KEQDQQPEQVKHEDQ-----H--------------QDQAVPPPTQSKQTVEELAV 213

Mouse   835 ELSQVRCSSEGAHLEHAELQDQLHRANTDTAELGIQVCALTAEKDRMEEALASLAQELQDSKEAA 899
            .||.:..::.|     .|.|..|....|.::.||              :.|..|::|...|:|..
  Fly   214 GLSSISITASG-----TESQSLLPEEVTASSVLG--------------QVLEELSEESSPSREPE 259

Mouse   900 LQERKGLELQVMQLQQE------KEKLQEKVKAAEEAASSFSGLQAQLAQAEQLAQSLQETAHQE 958
            .:...|:::.:..|...      .:::::.|:..||..........:.:|......::.|.:..|
  Fly   260 TEMTNGIDVPLANLPASVAEVPVPKEMEQPVQTEEEDVELPQEQHPRRSQPLTFCSTMDEISDTE 324

Mouse   959 QDALKFQLSAEIMDHQNRLKTANEECGHLRAQLEEQGQQLQMTKEAVQELEITKAAMEEKLNCTS 1023
            .|::..::.|:                      :.|....||.              :::.:|::
  Fly   325 LDSMLQEMDAD----------------------DNQADDQQMP--------------DDEKSCSA 353

Mouse  1024 SHLAECQATLLRKDEESTMLQTSL--------------ERTQKELEKATSKIQEYYN-------- 1066
            |.:.|.::..:..||:.|.....:              :..|.|....|:..::..:
  Fly   354 SPVTEEESVRILSDEQETTSNDQMNVDNFSQASTVEFADLKQPESTPVTAMGEDVASSFSSTESD 418

Mouse  1067 -----KLCQEV-TNRERNDQKMLADLDDLNRTKKYLEERL-IELLRDKDALWQKSDALEFQQK-- 1122
                 ||..|| .:||..|..:..|..:....:....:.| :...:.:.:...:.:..|.||:
  Fly   419 SLSGRKLDGEVEVDREHEDASLATDALETQEQRPQRPQTLNLNGCQAESSTPSQDENPEIQQETL 483

Mouse  1123 --LSAEEKCLG------------------------------------DMEVNHCHDCKREFSWIV 1149
              ....|...|                                    |.....|..|:::|:.|.
  Fly   484 QPTEVREGAAGVGVIPGEDDEESPIYEAVGYSDPHANLGKVPPIWVPDNMAGQCMQCQQKFTMIK 548

Mouse  1150 RRHHCRICGRIFCYYCCNN----YVVTKPSGKKERCCRACFQKFGE--GSGSNDSSGSGTSQGEP 1208
            ||||||.||::.|..||:.    ...|:|   :.|.|..|:....|  .:|.|..|..|::. .|
  Fly   549 RRHHCRACGKVLCSVCCSQRFRLEFATEP---ESRVCVQCYMILSERQANGLNSESAPGSAL-PP 609

Mouse  1209 SPMVSPAEASPQSIGS------QGINSVCRPPDDAVFDI 1241
            :|:.||...:|....|      |..||...||...:..:
  Fly   610 TPIRSPNPNNPMEYCSTIPPHRQVANSPGAPPPSVIVPV 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fyco1	NP_001103723.2	RUN	59..164	CDD:413440
		SMC_prok_B	294..1110	CDD:274008	92/569 (16%)
		FYVE_FYCO1	1130..1186	CDD:277265	21/95 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1191..1227		12/43 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1253..1289
		GOLD_2	<1378..1423	CDD:404736
Sara	NP_524729.2	FYVE_endofin	522..589	CDD:277268	21/69 (30%)
		SARA	614..650	CDD:288292	9/35 (26%)
		DUF3480	959..1321	CDD:288806
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2928
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.030