Protein Alignment Mef2c and Mef2

DIOPT Version :9

• Sequence 1: XP_011242797.1
• Gene: Mef2c / 17260
• MGIID: 99458
• Length: 484
• Species: Mus musculus
• Sequence 2: NP_001260842.1
• Gene: Mef2 / 36032
• FlyBaseID: FBgn0011656
• Length: 606
• Species: Drosophila melanogaster
• Alignment Length: 597
• Identity: 206/597 - (34%)
• Similarity: 275/597 - (46%)
• Gaps: 201/597 - (33%)

Mouse     1 MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKV 65
            ||||||||:||.|||||||||.|||||:||||||||||||||||||||:|:|||:||||||||:|
  Fly     1 MGRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSSNKLYQYASTDMDRV 65

Mouse    66 LLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSALNKKENKGSESPDPDSSYALTPR 130
            |||||||||||||.||.:|:|   |:..||..|||                 ||:.::.|.||||
  Fly    66 LLKYTEYNEPHESLTNKNIIE---KENKNGVMSPD-----------------SPEAETDYTLTPR 110

Mouse   131 TEEKYKKINEEFDNMIKSHKIP--------AVPPPSFEMPVTIPVSSHNSLVYSNPVSTLGNPNL 187
            ||.||.||:|||.||::.:::.        .:|..|:.:||::||.           .:.|: ||
  Fly   111 TEAKYNKIDEEFQNMMQRNQMAIGGAGAPRQLPNSSYTLPVSVPVP-----------GSYGD-NL 163

Mouse   188 LPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGY--------GNPRNSPGLL 244
            |. |.|.:...::||     .||:..|..:    ..||:.....|||        |:|  |||
  Fly   164 LQ-ASPQMSHTNISP-----RPSSSETDSV----YPSGSMLEMSNGYPHSHSPLVGSP--SPG-- 214

Mouse   245 VSPGNLNK-NIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSV---------NQRINNSQSAQ 299
            .|||..:. :|:.:||.    ..|.|..:|||:|||......|::         :||    ||..
  Fly   215 PSPGIAHHLSIKQQSPG----SQNGRASNLRVVIPPTIAPIPPNMSAPDDVGYADQR----QSQT 271

Mouse   300 SLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQH 364
            ||.||||::.|| :|..              |.||..:.|.||....|:|..:.|.:   |   |
  Fly   272 SLNTPVVTLQTP-IPAL--------------TSYSFGAQDFSSSGVMNSADIMSLNT---W---H 315

Mouse   365 LHNMPPSALSQLGACTSTHLSQSSNLSLPSTQ--SLSIKSEPVSPPRDRTTTPSRYPQHTTRHEA 427
            ...:|.|:||        ||:.|::...|:|.  |:.:|:||.|||||.:.:..:...:.:....
  Fly   316 QGLVPHSSLS--------HLAVSNSTPPPATSPVSIKVKAEPQSPPRDLSASGHQQNSNGSTGSG 372

Mouse   428 GRSPVDSLSSCSSSYDG------------------------------------------------ 444
            |.|     ||.||:..|
  Fly   373 GSS-----SSTSSNASGGAGGGGAVSAANVITHLNNVSVLAGGPSGQGGGGGGGGSNGNVEQATN 432

Mouse   445 ----SDREDHR----NEFHSPIGLTRPSP-------DER----------------------ESPS 472
                |..:.|.    |...|..|...|:|       |.|                      ::|:
  Fly   433 LSVLSHAQQHHLGMPNSRPSSTGHITPTPGAPSSDQDVRLAAVAVQQQQQQPHQQQQLGDYDAPN 497

Mouse   473 VKRMRLSEGWAT 484
            .||.|:|.||.|
  Fly   498 HKRPRISGGWGT 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mef2c	XP_011242797.1	MADS_MEF2_like	2..78	CDD:238165	67/75 (89%)
		HJURP_C	116..170	CDD:372061	24/61 (39%)
Mef2	NP_001260842.1	MADS_MEF2_like	2..78	CDD:238165	67/75 (89%)
		HJURP_C	95..155	CDD:289143	25/76 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7664
eggNOG	1	0.900	-	-		E1_COG5068
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31087
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3301
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D320201at33208
OrthoFinder	1	1.000	-	-		FOG0000108
OrthoInspector	1	1.000	-	-		otm42703
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1041
SonicParanoid	1	1.000	-	-		X116
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.960