DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cdc-48.3 and TER94

DIOPT Version :9

Sequence 1:	NP_492211.1	Gene:	cdc-48.3 / 172586	WormBaseID:	WBGene00010562	Length:	724	Species:	Caenorhabditis elegans
Sequence 2:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster

Alignment Length:	752	Identity:	211/752 - (28%)
Similarity:	349/752 - (46%)	Gaps:	178/752 - (23%)

- Green bases have known domain annotations that are detailed below.

Worm    76 ILINQQTMESL-----------GLLARQPVRIIHSSDSFIGIVWPCKEVALLKVSIISSRIARER 129
            :.::|..|:.|           |...::.|.|:.|.|:       |.:     ..|..:|:.|..
  Fly    61 VSLSQAKMDELQLFRGDTVILKGKRRKETVCIVLSDDT-------CPD-----EKIRMNRVVRNN 113

Worm   130 M-------ITLESCGRVEKLKSLSVTVKTSLTLNPALSG----FLEAYLSHSYLQYNSSVDLKYL 183
            :       ::::||..|:..|.:.:     |.::.:..|    ..|.||...:|:....:   ::
  Fly   114 LCVHLSDVVSVQSCPDVKYGKRVRI-----LPIDESTEGVTGNLFEIYLKPYFLEAYRPI---HM 170

Worm   184 GQN-------------VTVTPEEP--IESKMSAMGIDDD--KKRNSKVVSTAVGYKIQILNASAE 231
            |.|             |.:|..||  |.:..:.:..|.|  |:...:....||||
  Fly   171 GDNFIVRAAMRPIEFKVVLTDPEPYCIVAPETVIFCDGDPIKREEEEESLNAVGY---------- 225

Worm   232 GSTSDVLQTLPTDLSNIGGCFTAKQVLEDYVISPVRQK--------ESPCSVLIWGLPGSGKTLL 288
                          .:||||......:::.|..|:|..        :.|..:|::|.||:||||:
  Fly   226 --------------DDIGGCRKQLAQIKEMVELPLRHPSLFKAIGVKPPRGILMYGPPGTGKTLI 276

Worm   289 LKEVALVLSGSTTYIGSCEELMELNGVTTGNI------------VIVDVNEL------------E 329
            .:.||.........|...|.:.:|.|.:..|:            .|:.::|:            |
  Fly   277 ARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNSPAIIFIDEIDAIAPKRDKTHGE 341

Worm   330 KENTKANRALSFLLGDEKK---CVILCVRSSETLDIGFR--VRFPIEAEITVPTQDERLDILSKI 389
            .|....::.|:.:.|.:|.   .|:.......::|...|  .||..|.:|.:|....||::|
  Fly   342 VERRIVSQLLTLMDGMKKSSHLIVMAATNRPNSIDPALRRFGRFDREIDIGIPDATGRLEVL--- 403

Worm   390 GNIYNFPLELHLDV-----ARHTHGFTGGDLCSLLKAAKFARGRTHLERVN------DAR----- 438
             .|:...::||.||     |..:||..|.||.||...|...:.|..::.::      ||.
  Fly   404 -RIHTKNMKLHDDVDLEQIAAESHGHVGADLASLCSEAALQQIREKMDLIDLEDDKIDAEVLASL 467

Worm   439 -----------KRIRPTGIRQFILEVPNVSWNDIGGNEELKLEIQQAVIWPQKHPEAFERFGIDP 492
                       .:..|:.:|:.::||||.:|.||||.|.:|.|:|:.|.:|.:||:.|.:||:.|
  Fly   468 AVTMENFRYAMTKSSPSALRETVVEVPNTTWTDIGGLESVKKELQELVQYPVEHPDKFLKFGMQP 532

Worm   493 PAGILLYGPPGCSKTLIARALASEAKMNFLAVKGPELFSKWVGDSEKAIRDLFSRARQVAPTIVF 557
            ..|:|.||||||.|||:|:|:|:|.:.||::||||||.:.|.|:||..:||:|.:||..||.::|
  Fly   533 SRGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARSAAPCVLF 597

Worm   558 FDEIDAVGSSRGSE--KSSGVSDRVLAQLLTELDGLEKSSRVILLAATNRPDQLDSALLRPGRLD 620
            |||:|::..:||..  .:.|.:|||:.|:|||:||:.....|.::.||||||.:|.|:|||||||
  Fly   598 FDELDSIAKARGGNVGDAGGAADRVINQILTEMDGMGAKKNVFIIGATNRPDIIDPAILRPGRLD 662

Worm   621 RAIYVGLPCEVTRRAILEMRTKKMKFDDTVRTIDKLVEKTSGYSGAELVAVCRTAAMFAMRESID 685
            :.||:.||.:.:|.|||:...:|......| .:..:.:.|.|:|||:|..:|:.|...|:|::|:
  Fly   663 QLIYIPLPDDKSREAILKANLRKSPLAKEV-DLTYIAKVTQGFSGADLTEICQRACKLAIRQAIE 726

Worm   686 ATI------------------------VQWTHFEQAL 698
            |.|                        :...|||:|:
  Fly   727 AEIRREKERAENQNSAMDMDEDDPVPEITSAHFEEAM 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cdc-48.3	NP_492211.1	TIP49	<247..720	CDD:332389	175/542 (32%)
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	211/752 (28%)
		CDC48_N	47..129	CDD:280513	14/79 (18%)
		CDC48_2	153..213	CDD:215011	13/62 (21%)
		AAA	263..392	CDD:278434	28/128 (22%)
		AAA	536..669	CDD:278434	68/132 (52%)
		Vps4_C	<741..783	CDD:286426	4/23 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820