DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Abcc1 and MRP

DIOPT Version :9

Sequence 1:	NP_032602.1	Gene:	Abcc1 / 17250	MGIID:	102676	Length:	1528	Species:	Mus musculus
Sequence 2:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster

Alignment Length:	1576	Identity:	778/1576 - (49%)
Similarity:	1055/1576 - (66%)	Gaps:	91/1576 - (5%)

- Green bases have known domain annotations that are detailed below.

Mouse     6 FCSADGSDPLWDWNVTWHTSNPDFTKCFQNTVLTWVPCFYLWSCFPLYFFYLSRH-DRGYIQMTH 69
            ||.:    ..|:...||:|::||||.||:.|.|.|.||.:.|:.....|:||... ||. |....
  Fly    12 FCGS----TFWNATETWYTNDPDFTPCFEQTALVWTPCAFYWAFVIFDFYYLKASLDRN-IPWNK 71

Mouse    70 LNKTKTALGFFLWIICWADLFYSFWERSQGVLRAPVL---LVSPTLLGITMLLATFLIQLERRKG 131
            ||.:|..:...|.:|...||..:..::. |....|:.   :..|.:...|.||....|.|.|:.|
  Fly    72 LNVSKALVNLGLLVITALDLIMALVKKG-GDSELPLYDLDVWGPIIKFATFLLLFIFIPLNRKYG 135

Mouse   132 VQSSGIMLTFWLVALLCALAI-----------LRSKIISA---LKKDAHVDVFRDSTFYLYFTLV 182
            ||::|....||.  ||..|:|           .|.||:::   .::|...:.::..:|:::||..
  Fly   136 VQTTGCQFIFWF--LLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFSWEEYQFVSFFIFFTFT 198

Mouse   183 LVQLVLSCFSDCSPLFSETVHDRNPCPESSASFLSRITFWWITGMMVHGYRQPLESSDLWSLNKE 247
            .:.|:|:||:|..|..::.....|..||.|||||||||:.|...|.:.|||.|||..|||.|..:
  Fly   199 SIMLILNCFADGMPRQTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQ 263

Mouse   248 DTSEEVVPVLVNNWKKECDKSRKQPVRIVYAPPKDPSKPKGS-SQLDVNEEVEALIVKSPHKDRE 311
            |:..||:|:..::|.:...|:.|...|:         :||.. |..:|..|       :||.::.
  Fly   264 DSCSEVMPIFAHHWNQNVRKNYKNKARV---------EPKAQFSNGNVTFE-------NPHGEKN 312

Mouse   312 ------PSLFKVLYKTFGPYFLMSFLYKALHDLMMFAGPKILELIINFVNDREA-PDWQGYFYTA 369
                  .|:...:||:||..||...|.|...|.:.||.|::|.|||:||..::| |:|:|..|..
  Fly   313 GRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAV 377

Mouse   370 LLFVSACLQTLALHQYFHICFVSGMRIKTAVVGAVYRKALLITNAARKSSTVGEIVNLMSVDAQR 434
            ||||.|..||..|.||||..|:.|:||:||::.|:|||||.|:|:.:|.||||||||||:|||||
  Fly   378 LLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQR 442

Mouse   435 FMDLATYINMIWSAPLQVILALYFLWLSLGPSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSK 499
            ||:|.||:|||||||||:.|||||||..||||||||:||||:::|:|.|:|.:.||||:..||.|
  Fly   443 FMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYK 507

Mouse   500 DNRIKLMNEILNGIKVLKLYAWELAFQDKVMSIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALS 564
            |.|:|||||:|:|||||||||||.:|:.:|:.||.:|:..|:.:|||.|..:|.|.|.||||:|.
  Fly   508 DERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLV 572

Mouse   565 TFAVFVTVDERNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPD 629
            |||.:|...|.|.|..:|..||:|||::::.||.||||:...|.:..||:.|:..||:.|||:|:
  Fly   573 TFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPN 637

Mouse   630 SIERRSIKSGEGNSITVKNATFTWARGEPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAE 694
            |:...|.|.   :.::::|..|:|  |:..||..|...:.:|:|||:||.||.||||::.|.|.|
  Fly   638 SVLHDSSKP---HPMSIENGEFSW--GDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGE 697

Mouse   695 MDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGHPLQENYYKAVMEACALLPDLEILPSGDRT 759
            |:|:.|.|...|.:|||||||||||.::|:|||||.......|..|::||||..|::||.:||.|
  Fly   698 MEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLT 762

Mouse   760 EIGEKGVNLSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRIL 824
            ||||||:|||||||||:||||||||::|:||.|||||||||||||||||:|:||.|:|..|:|:|
  Fly   763 EIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVL 827

Mouse   825 VTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFLRTY---ANAEQD--------LAS 878
            ||||:::|||||.|.|:..|:|||.|::.:|:...||||:|:..:   .|.|::        ::|
  Fly   828 VTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISS 892

Mouse   879 EDDSVSGSGKESKPVE--------NGMLVT--DTV---GKHLQRHLSNSSSHSGDTSQQHSSIAE 930
            ..|.....|...|.::        :.:.||  |::   |..|:|......||     ...:|.|.
  Fly   893 TADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSH-----DSVASAAS 952

Mouse   931 LQKAGAKEETWKLMEADKAQTGQVQLSVYWNYMKAIGLFITFLSIFLFLCNHVSALASNYWLSLW 995
            |:|  .:|...||:|.:|:|||.|:.:||.:|:|::|:|::..::.|........:.||.||:.|
  Fly   953 LKK--KQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQW 1015

Mouse   996 TDDPPVVNGTQANRNFRLSVYGALGILQGAAIFGYSMAVSIGGIFASRRLHLDLLYNVLR-SPMS 1059
            .:|..|.|.| ..|:..|.||||.|..||...:...:.|.:||..|::.:|.:||..::| |...
  Fly  1016 ANDQNVANDT-GLRDMYLGVYGAFGFGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCR 1079

Mouse  1060 FFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYF 1124
            ||:.||.|.|:|.||.::|.||..:|..:..||..:|.|:..:::|.|:|||...:|.|:..:|:
  Fly  1080 FFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYY 1144

Mouse  1125 FVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPS 1189
            |.||||||:||||.|||||||||:||||:||:.|.|.|||:...:|||.:||.|||:||...|||
  Fly  1145 FAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPS 1209

Mouse  1190 IVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETN 1254
            ::||||||:|||.|||.|:|||:||||:...: :.|||||||||:||:|..|||||||||::|||
  Fly  1210 VIANRWLAIRLEMVGNLIILFASLFAVLGGQT-NPGLVGLSVSYALQVTQTLNWLVRMSSDIETN 1273

Mouse  1255 IVAVERLKEYSETEKEAPWQI-QETAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGE 1318
            ||:|||:|||.||::||||:: |:...|..||..|||||:::.:||||.|||||:.::..|:|||
  Fly  1274 IVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGE 1338

Mouse  1319 KVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPVLFSGSLRM 1383
            |||||||||||||||||.||||.|:|.|.|.||||:||.:|||.||.::|||||||||||||||:
  Fly  1339 KVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRI 1403

Mouse  1384 NLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKIL 1448
            |||||...:|:|:|.||||:|||.||.:|...||||.||||||||||||||||||||||||||:|
  Fly  1404 NLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVL 1468

Mouse  1449 VLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEVRECGAPSELLQ 1513
            ||||||||||||||:|||.||||:|::|||||||||||||:|..:|||||||::.|..:|:|||.
  Fly  1469 VLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLD 1533

Mouse  1514 Q-RGIFYSMAKDAGLV 1528
            . :..||||||||.||
  Fly  1534 NPKSAFYSMAKDANLV 1549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abcc1	NP_032602.1	MRP_assoc_pro	7..1527	CDD:188098	775/1572 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	876..895		4/26 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	909..929		4/19 (21%)
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	774/1571 (49%)
		ABC_membrane	338..601	CDD:279056	153/262 (58%)
		ABCC_MRP_domain1	649..848	CDD:213217	118/200 (59%)
		ABC_membrane	988..1260	CDD:279056	130/273 (48%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	162/219 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841646
Domainoid	1	1.000	339	1.000	Domainoid score	I1099
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1450	1.000	Inparanoid score	I114
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	1	1.000	-	-		otm43692
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	LDO	PTHR24223
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8
SonicParanoid	1	1.000	-	-		X177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800