Protein Alignment Anapc1 and shtd

DIOPT Version :9

• Sequence 1: NP_032595.2
• Gene: Anapc1 / 17222
• MGIID: 103097
• Length: 1944
• Species: Mus musculus
• Sequence 2: NP_573025.2
• Gene: shtd / 32473
• FlyBaseID: FBgn0004391
• Length: 2030
• Species: Drosophila melanogaster
• Alignment Length: 2129
• Identity: 733/2129 - (34%)
• Similarity: 1105/2129 - (51%)
• Gaps: 326/2129 - (15%)

Mouse    11 MIAAGDLQ-EFVPFGRDHCKHH-------------PNALNLQLRQLQPASELWSSDGAAGLVGSL 61
            |||..:.. ||||.||.....|             |...:|.|::||..:  .||.|.....|..
  Fly     1 MIAVAEPPLEFVPRGRQTSAEHPGPHDQPMARHQLPTTEHLLLQRLQNVN--ISSAGEDCPSGGQ 63

Mouse    62 QEVTI------HEKQKESWQLRKGVSE------------------------IGDAADY----DEE 92
            :..|:      :|..:|...||:.::|                        :....||    :||
  Fly    64 ESWTVRELYDDYEASEERAALRRKLTERTKRCGLQATSLPNRLLNPPLVRRVEPMCDYMVNNEEE 128

Mouse    93 LYVAGNMVIWSKG---SKSQALAVYK--AFTVDSTVQQALWCD--FI---ISQDKSEKIYKSHEL 147
            |||..|.|:|::|   .......||:  .||.|:.|:.|.:.:  |:   ::|.|: .::...:.
  Fly   129 LYVNRNTVVWTQGVNDDDDTDNGVYRRMCFTTDTPVRFACFLNRSFVRGRLAQLKA-AVHPDDDH 192

Mouse   148 EKCICILQSSCMNMHSIDGKDYIASLPFQVANVWATKYGLLFERCSSSHEVPPSLPREPLPTMFS 212
            ...||::....:.::..:|:|::|:|.|.|:.:|.||||||.|:.||:..:  |....|:|.:||
  Fly   193 LTAICVMDQDALRVYCSNGEDFLANLDFPVSQLWQTKYGLLLEKDSSNALI--SHMSIPMPRLFS 255

Mouse   213 MLHPLDEITPLVCKSGSLFGSSRVQYVVDPAVKIVFLNIDPSIVMTYDAVQNVHSVWTLRRVKPE 277
            |.|||.|..|:|.|:.:  ||:  .|:.:|...:||...:..:||.|||....|.|..||:|.||
  Fly   256 MSHPLHEACPVVLKTAT--GST--GYMTEPEYTVVFTTEESDLVMLYDAKFFKHFVARLRKVTPE 316

Mouse   278 EENAVLKFPEQAGTLQ-------NATTSSSLTAHLRSLSKGESPVASPFQNYSSIHSQSRSTSSP 335
            |.|.|.:..|...||.       |:.:|:..|        |.:|.|:           :.|.::.
  Fly   317 EINYVSQQMELGQTLMGPRSMAGNSFSSTKQT--------GATPKAT-----------NLSFAAR 362

Mouse   336 SLHSRSPSISNMAALSRAHSPALGVHSFSG----AQRFNLSSHSQSPKRHSISHSPSGSFND--- 393
            ::::.:..:.|...||::       .||||    :.|.:|.: ..|..:.|||.. |.|..|
  Fly   363 NINTTTTGMGNQFGLSQS-------QSFSGVLGQSNRASLGT-PLSQLQSSISQQ-SMSVKDMRK 418

Mouse   394 -SFLAPETEPIVPELCIDHLWTETLPNI-REKNSQASKVFITTDLCGQKFLCFLVEAQLQLRCVK 456
             :.:.| .:||.||||::|:|||.:... ||....|::.||.|||.||.|||:|:....:|:.|:
  Fly   419 LTHVKP-AKPIEPELCMEHIWTENIYGTQREFCEMATRAFIHTDLVGQTFLCYLLARSCRLQLVR 482

Mouse   457 FQESNDKTQLIFGSVTNIHAKDAAPVEKIHTMLVLEGNGNLVLYTGVVRVGKVFI------PGLP 515
            ..........:....:.:.||||..::::|.:.||:.:|:|:||||.|.:.||.|      ..:|
  Fly   483 LTGYGRGEVQLSTHASTLAAKDAVGLKRMHMIAVLDPSGSLLLYTGTVLISKVHITPFLAPTSIP 547

Mouse   516 APSLTMSNMMPRPS---------TPLDGVGTPKPLSKLLGSMDEVVLLSPVPELRDSSKL----- 566
            .|.:|.....|.||         ||:...|   |.|.:.......|      |:|.||.|
  Fly   548 TPLVTPMTAAPSPSASPAPSHVKTPMAAAG---PASGIPSGSSSFV------EVRRSSLLPTKAP 603

Mouse   567 -NDSLYNEDC-------------TFQQLGTYIHSVRDPVHNRVTLELSNGSMVRITIPEVATSEL 617
             :.:.:.|:.             |.:|......|:|||..||:||..:.|.|:||.:|.:..:.|
  Fly   604 GDVAAFEEELHMLSPIQPQPVSYTQRQAHNVCKSLRDPAGNRLTLVYATGRMLRIALPFLNDTRL 668

Mouse   618 VQTCLQAIKFILPKEVAIQVLVKWYNVHSAPGGP--SCHSEWSLFVICLLNMMGY---------- 670
            :..|:..::.:|.....:..:::||:..:.||..  |...||.||...||.:||.
  Fly   669 LTRCVATLRQVLSPTQFLDFVIRWYSDRNPPGSRNYSIEQEWLLFRSTLLALMGLTAAPDVDAGE 733

Mouse   671 NTDRLAW-------------TRSFD-----FEGSLSPVIAPKKAR---PSDTGSDEDWEYLLNSE 714
            |..|.|.             |.|.|     ...:|.....|||.|   ..|..:|:|||:|
  Fly   734 NYARCATPPLHTQFGGGATATESSDGSSCSSNSTLGGQDEPKKRRIYNDCDDFTDDDWEFL---- 794

Mouse   715 YHRNVESHLLNKSLCLTALEVSNAKDEDFSQNLSLDSSTLLFAHIPAIFFVLHLVYEELKLNTLM 779
                         |..|.|....|....:|.|:    ..|||..||||||.|||:||:|||:...
  Fly   795 -------------LLQTTLAPCGADGHSYSVNI----GALLFRMIPAIFFSLHLLYEDLKLDADF 842

Mouse   780 GEGICSLIDLLVQLARDLKLDSYLDHYYRDSPTLVKTTGQVCTIDQGQMGFMHHPPFFTSEPPSI 844
            ...:..|...|.|||.|::|:||:.||..|.|.|...||::..:.......|.|........||:
  Fly   843 YGALPYLATFLHQLAIDMQLESYVLHYILDFPELSNRTGKLSLLGAEHGAMMLHQELLRVPAPSV 907

Mouse   845 YQWVSSCLKG-EGMPPYPYLPGICERSRLVVLSIALYTLGDESCVSDETCQYLSKVTSTPQKPQA 908
            :..:...:.| |.:.||.:|..:.||||:::..::|.|.|      .|...|..::...|...||
  Fly   908 FAQLEHIIVGEEEVMPYTFLECVNERSRILLQLVSLVTHG------HERLNYWWQLLEIPGAVQA 966

Mouse   909 EQEENRFTFRHSASVSVLAER---LVVWMASVGFTLRDLETLPFGIALPIRDAIYHCREQPDSDW 970
                 .||.|...:::..|.|   ::..:.::..|.||:|..|..:.|.:.:|:...|..|....
  Fly   967 -----NFTRRSKRNITADAPRSHQMLQLLLAMRLTRRDIERFPAAVHLIVAEALEEARLSPPMGC 1026

Mouse   971 SEAVCLLIGRQDLSKQA-------------C-----EGNL-----PRGKSVLSSEVSSGTEAEEE 1012
            |.|...||.|.:|:..|             |     |.:|     |.|    .||..|..:...:
  Fly  1027 SMATYELILRPELAAHAQLPFLETSTGQPHCGRVYKEDSLSARCPPTG----GSETDSPAQLRRD 1087

Mouse  1013 DDGMNDLNHEVMSLIWSEDLRVQDVRRLLQSAQPVRVNVVQYPELSDHEFIEEKENRLLQLCQRT 1077
            |  |::::.:::.|.:.:|:||.:|||||.|::||.:.|.|.|..||||||||:|.:|..||.||
  Fly  1088 D--MDNMDTKLLRLRFPDDMRVDEVRRLLNSSEPVVIEVQQAPGTSDHEFIEEQEKQLFALCSRT 1150

Mouse  1078 MALPVGRGMFTLFSYHPVPTEPLPVPKLNLTGRAPPRNTTVDLNSGNIDVPPNMASWASFHNGVA 1142
            |.||||||||||.:..|.|:|.|.:|||.|.|:.|.:.||:::.  .|:.|.||..|.|||||||
  Fly  1151 MTLPVGRGMFTLRTMLPRPSESLTMPKLCLLGKEPLKGTTIEMQ--QIEFPANMQMWPSFHNGVA 1213

Mouse  1143 AGLKIAPASQ-IDSAWIVYNKPK-HAELANEYAGFLMALGLNGHLTKLATLNIHDYLTKGHEMTS 1205
            .||||:|.:| |||.|||||||| |:..|.|:|||||||||||||..|:.::::.||.|..|||:
  Fly  1214 TGLKISPQAQDIDSNWIVYNKPKTHSHNALEHAGFLMALGLNGHLKTLSFMSVYKYLVKCDEMTN 1278

Mouse  1206 IGLLLGVSAAKLGTMDMSITRLLSIHVPALLPPTSTELDVPHNVQVAAVVGIGLVYQGTAHRHTA 1270
            :|||||:|||..||||...|:|||:|:.||||.|:.|||:|.:.||||::|:||:|||:|.||.|
  Fly  1279 VGLLLGISAAHRGTMDTKTTKLLSVHLEALLPATAMELDIPQSTQVAAIMGVGLLYQGSAKRHIA 1343

Mouse  1271 EVLLAEIGRPPGPEMEYCTDRESYSLAAGLALGMVCLGHGSNLIGMSDLNVPEQLYQYMVGGHRR 1335
            ||||.|||||||||||...:||||::.|||:||:|.||.|.:..|:.||.:|:.|:.|||||.:|
  Fly  1344 EVLLQEIGRPPGPEMENSIERESYAMTAGLSLGLVTLGQGESPAGLRDLQLPDTLHYYMVGGVKR 1408

Mouse  1336 FQTGMHREKHKSPSYQIKEGDTINVDVTCPGATLALAMIYLKTNNRSIADWLRAPDTMYLLDFVK 1400
            ...|..:||::..|:|::||||:|:|||.|||||||.:::..:.|.:||:|::.||:.||||.|:
  Fly  1409 PIGGSQKEKYRLASFQVREGDTVNIDVTAPGATLALGLMFFNSGNAAIAEWMQPPDSRYLLDMVR 1473

Mouse  1401 PEFLLLRTLARCLILWDDILPNSKWVDSNVPQIIRENSISLSEIELPCSE--------DLNLETL 1457
            |:||||||::|.||||.|:.|::.|..:..|:.:|      :.::||..|        |::.|.:
  Fly  1474 PDFLLLRTISRGLILWQDVRPDNAWFQAQFPRALR------AHLKLPFYENEYAPEDYDVDYEAI 1532

Mouse  1458 SQAHVYIIAGACLSLGFRFAGSENLSAFSCLHKFAKDFMNYLSAPNASVTGPYNLETCLSVVLLS 1522
            |||:..|:|||...:|.::||:|||.||:.|....|||:.:.|.|.....|...:|:||.|:|:|
  Fly  1533 SQAYCNIMAGAAFCIGLKYAGTENLVAFATLRSVIKDFLRFPSRPMGECAGRTTVESCLMVLLIS 1597

Mouse  1523 LAMVMAGSGNLKVLQLCRFLHMKTGGE---MNYGFHLAHHMALGLLFLGGGRYSLSTSNSSIAAL 1584
            :::|.|||||.::|::.|||..:.|.:   :.||.|:|.||:|||||||.||:::|.:..|||||
  Fly  1598 ISLVFAGSGNCEILRIIRFLRSRVGPQYPHITYGSHMAIHMSLGLLFLGAGRFTISQTPESIAAL 1662

Mouse  1585 LCALYPHFPAHSTDNRYHLQALRHLYVLAAEPRLLVPVDVDTNTPCYALIEVTYKGTQWYEQTKE 1649
            :||.:|.||.||.||||||||||||||||.||||.:|.|:|||..|.|.|.|...|.   .:.:.
  Fly  1663 VCAFFPKFPIHSNDNRYHLQALRHLYVLAVEPRLFLPRDIDTNKLCLANISVLEVGA---TELRR 1724

Mouse  1650 ELMAPTLLPELHLLKQMKVKGPRYWELLIDLSKGEQHLRSILSKDGVLYVKLRAGQLSYKEDPMG 1714
            ..:||.:||.|..|:|:.|....||.:..:.|:....|...|.....:.:|.|.|.||:.|||..
  Fly  1725 LPIAPCILPVLSTLQQVVVDDENYWPVCFERSRNWDQLEKALEMSAPIDIKKRTGCLSHLEDPDR 1789

Mouse  1715 WQSLLAQTVANRNSEARAFKPETISSFTSDPALLSFAEYFCKPT--VSMGP-----KQEILDLFS 1772
            .:|:||||:....|.........:..|.|:..:..|... |..|  ..:.|     :.:::.||
  Fly  1790 LKSMLAQTLTMEQSICWQIDMNDLQQFASERMVKQFLSR-CLDTKGTDLSPPELMKRHQVMLLF- 1852

Mouse  1773 SILYECVAQETPEMLPAYIAM-DQALRSLKKRDMSDTSDLWQIKLILEFFSSRSHQDRQHTYPKR 1836
               |..|.::....||.|:.: |...:|     |.:..|:||:||| :.:.||| |:.:|.
  Fly  1853 ---YNAVVKDRMHFLPVYLTLYDHVTKS-----MPNNIDVWQMKLI-DAYLSRS-QESEHP---- 1903

Mouse  1837 GLFINSEFLPVVKCTVDATLDQWLQAGGDVC--VHAYLSGQPVEKSQLNMLA--------CFLVY 1891
              .|:.|.:.:::   :....:...:..::|  :..:||.:.::.|.:..::        |.:.|
  Fly  1904 --LISVELIQMMQ---ELFKQEMEDSTRELCLPLREFLSRRRLDPSYVTTVSGPDLQRAFCVINY 1963

Mouse  1892 HSVPAPRHLPPM--GLE---GSTSFAELLYRFRHLKMPVRALLRLAPVL 1935
            :::     ||.|  |::   |:.::..|||.||.|.:....:..|..:|
  Fly  1964 YNL-----LPNMLNGVDLSTGTVNYMRLLYEFRRLNLGAHTIFGLMKIL 2007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Anapc1	NP_032595.2	ANAPC1	150..>218	CDD:289618	26/67 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	312..343		3/30 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	370..395		8/28 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	991..1014		6/27 (22%)
		PC 1	1297..1325		13/27 (48%)
		PC 2	1366..1404		18/37 (49%)
		PC 3	1467..1501		14/33 (42%)
		PC_rep	1467..1501	CDD:280095	14/33 (42%)
		PC 4	1520..1552		13/34 (38%)
shtd	NP_573025.2	ANAPC1	195..298	CDD:289618	39/108 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842690
Domainoid	1	1.000	732	1.000	Domainoid score	I106
eggNOG	1	0.900	-	-		E1_KOG1858
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7414
Inparanoid	1	1.050	1027	1.000	Inparanoid score	I276
Isobase	1	0.950	-	0	Normalized mean entropy	S5090
OMA	1	1.010	-	-		QHG46987
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005152
OrthoInspector	1	1.000	-	-		oto92272
orthoMCL	1	0.900	-	-		OOG6_102115
Panther	1	1.100	-	-	LDO	PTHR12827
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R68
SonicParanoid	1	1.000	-	-		X3674
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740