DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lron-11 and Fili

DIOPT Version :9

Sequence 1:	NP_491035.1	Gene:	lron-11 / 171837	WormBaseID:	WBGene00022129	Length:	542	Species:	Caenorhabditis elegans
Sequence 2:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	429	Identity:	122/429 - (28%)
Similarity:	200/429 - (46%)	Gaps:	47/429 - (10%)

- Green bases have known domain annotations that are detailed below.

Worm     4 PVLILLVLVSGVIS------CQSGCKC---PTKTTAVCKGSSLRSIPILLDPRTTVLDLSNNRIS 59
            |||:||:|...::.      |.|.|:|   ...:.|:|..::|..:||.|:|.|..::|:.|||.
  Fly    22 PVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIR 86

Worm    60 RLSADELSL--YPNLEQLILHNNSITHLSADVFSTLPSLRVLDLSSNSLLSLPNEVFSKLKNLKT 122
            .|   |.||  |..||.|.|..|.|..|.:..|.....||.|:||.|.:.||....|..|.||..
  Fly    87 TL---EFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLL 148

Worm   123 LIISSNDVQ-LGPECFAGLSQLQTLSIADNRLSFLPPSVLKPLSGLRNLDLSANKLLSMPASVMN 186
            |.:|.|.:: :.|...:.|:.|..|.:.:|.:..|..:..|.::.|..|....|:||.:|||.:.
  Fly   149 LDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLW 213

Worm   187 NLGGLETLKLKQNLLSSLETGMFLSQKELKHLDVSENLIGDIEEGALYGLEKLETLNLTNNQLVR 251
            :|..|::|.:..||:..:....|...|||..|.|..|::.:::..|..||..|:.|:|::|.|..
  Fly   214 HLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTM 278

Worm   252 LPGNTWSLPALKTLDLSSNLFVSLETASFDGLPALQYLNISHSRN--------LKTIQMATFVQL 308
            :|....|       .||:..:::|....|..|||:.:||:.|.|.        |:.|....||..
  Fly   279 VPTQQLS-------KLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDN 336

Worm   309 SSLHWLSISSS-ALTHIHPSAFNPIPPLSHLDLSNNELRYVAPGMLQWPNIRNLHLANNDWHCSC 372
            :.|..|.:::: .|:.|....|...|.:..:.:.:|.|:.:.........::.|:|.:|...|:|
  Fly   337 THLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNC 401

Worm   373 DL---------RVSNLNPRDDAKCSGPENLAGAPINELS 402
            .|         ....::|       |.|:.||..:..|:
  Fly   402 SLLWLWRLVTGNFEGVDP-------GMEHAAGGAVAALA 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lron-11	NP_491035.1	leucine-rich repeat	48..71	CDD:275380	10/24 (42%)
		LRR_RI	<50..177	CDD:238064	42/129 (33%)
		LRR_8	70..130	CDD:290566	23/59 (39%)
		leucine-rich repeat	72..95	CDD:275380	8/22 (36%)
		leucine-rich repeat	96..119	CDD:275380	10/22 (45%)
		LRR_8	118..177	CDD:290566	15/59 (25%)
		leucine-rich repeat	120..142	CDD:275380	6/22 (27%)
		LRR_RI	<141..270	CDD:238064	37/128 (29%)
		leucine-rich repeat	143..166	CDD:275380	5/22 (23%)
		leucine-rich repeat	167..190	CDD:275380	9/22 (41%)
		LRR_8	190..249	CDD:290566	18/58 (31%)
		leucine-rich repeat	191..214	CDD:275380	5/22 (23%)
		leucine-rich repeat	215..238	CDD:275380	7/22 (32%)
		LRR_8	238..295	CDD:290566	17/56 (30%)
		leucine-rich repeat	239..261	CDD:275380	7/21 (33%)
		leucine-rich repeat	262..283	CDD:275380	4/20 (20%)
		LRR_8	284..345	CDD:290566	17/69 (25%)
		leucine-rich repeat	286..310	CDD:275380	8/31 (26%)
		leucine-rich repeat	311..334	CDD:275380	5/23 (22%)
		leucine-rich repeat	335..357	CDD:275380	2/21 (10%)
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	10/24 (42%)
		leucine-rich repeat	98..121	CDD:275380	8/22 (36%)
		LRR_8	120..180	CDD:404697	20/59 (34%)
		leucine-rich repeat	122..145	CDD:275380	10/22 (45%)
		leucine-rich repeat	146..169	CDD:275380	6/22 (27%)
		LRR	<161..>354	CDD:227223	55/199 (28%)
		leucine-rich repeat	170..193	CDD:275380	5/22 (23%)
		leucine-rich repeat	194..217	CDD:275380	9/22 (41%)
		leucine-rich repeat	218..265	CDD:275380	14/46 (30%)
		leucine-rich repeat	266..289	CDD:275380	8/29 (28%)
		leucine-rich repeat	290..313	CDD:275380	7/22 (32%)
		leucine-rich repeat	314..338	CDD:275380	5/23 (22%)
		LRR_8	337..397	CDD:404697	11/59 (19%)
		leucine-rich repeat	339..360	CDD:275380	5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14510
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910