DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mark3 and AMPKalpha

DIOPT Version :9

Sequence 1:	XP_006515574.1	Gene:	Mark3 / 17169	MGIID:	1341865	Length:	806	Species:	Mus musculus
Sequence 2:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	488	Identity:	168/488 - (34%)
Similarity:	252/488 - (51%)	Gaps:	79/488 - (16%)

- Green bases have known domain annotations that are detailed below.

Mouse    44 ASCADEQP--HIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTS-LQKLFREVR 105
            |..|:.||  .||:|.|..|:|.|.|.|||:..|.:|..:||:||:::.::.... :.|:.||::
  Fly    14 AGSANGQPLVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQ 78

Mouse   106 IMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 170
            .:|:..||:|:||::||.|...:::||||.||||:|||:|.||:::|.:||..|:||:|.|.|||
  Fly    79 NLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCH 143

Mouse   171 QKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVD 235
            :..|||||||.||||||.:|::||||||.||....|..|.|.||||.|||||:..||.|.|||||
  Fly   144 RHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVD 208

Mouse   236 VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPVKRGTLEQ 300
            :||.|||||.|:.|:||||.:::..|..::..|.:.||.|::....||:.:.|.::|:||..:|:
  Fly   209 IWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEE 273

Mouse   301 IMKDRWINAGHEEDELKPFVEPELDISDQKRID------IMVGMGYSQEEIQES-LSKMKYDEIT 358
            |.|..|.     :.:|..::.|.....|...||      :....|..:.|:..| ||...:|::.
  Fly   274 IKKHEWF-----QKDLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLA 333

Mouse   359 ATYLLL--GRKSAELDASDSSSSSNLSLAKVRPNSDLSNSTGQSPHHKGQRSVSSSQKQRRYSDH 421
            ..|.|:  .::.|:..|:..:..:|..:|            |..|.........||.      ||
  Fly   334 IAYHLIIDNKRFADDAANQINEINNFFVA------------GSPPPPPPPPVPQSSM------DH 380

Mouse   422 AGPAIPSVVAYPKRSQTSTADSDLKEDGIPSRKSSSSAVGGKGIAPASPMLGNAGNPNK------ 480
            ..|.....|.....:.:.||                        .|..|:.|  |.|:.
  Fly   381 QAPLATVTVGGGTSASSGTA------------------------TPVPPVAG--GTPSSTIPIRP 419

Mouse   481 -----ADIPERKKSPAVPSS-------NTASGG 501
                 |.:.:|:.:.:|.:|       .||.||
  Fly   420 HPERIAPMRDRQLAMSVQTSGGGAFPEKTARGG 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mark3	XP_006515574.1	STKc_MARK	55..307	CDD:270974	121/252 (48%)
		UBA_MARK3_4	325..367	CDD:270590	11/50 (22%)
		MARK1-3_C	707..804	CDD:213381
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	123/254 (48%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	13/62 (21%)
		AMPKA_C	457..580	CDD:213378
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910