DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mark3 and CG9222

DIOPT Version :9

Sequence 1:	XP_006515574.1	Gene:	Mark3 / 17169	MGIID:	1341865	Length:	806	Species:	Mus musculus
Sequence 2:	NP_608999.2	Gene:	CG9222 / 33867	FlyBaseID:	FBgn0031784	Length:	337	Species:	Drosophila melanogaster

Alignment Length:	260	Identity:	104/260 - (40%)
Similarity:	156/260 - (60%)	Gaps:	20/260 - (7%)

- Green bases have known domain annotations that are detailed below.

Mouse    60 KTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQK-LFREVRIMKILNHPNIVKLFEVIE 123
            |.||.||:||||:......|:.||:|||.|.:......|| |.||:..:|.|:|.|::..::.||
  Fly    80 KVIGTGNYAKVKIGFSEEYGKRVAVKIISKVKAPSEYTQKFLPREIEAVKGLHHENLITFYQSIE 144

Mouse   124 TEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDA 188
            |...:||||:.|..|.:.||:.....:.|.::|..|:|:||||:|.|.|.:||||:|.||||||.
  Fly   145 TSHRVYLIMQLAENGTLLDYVRERKFLDEPQSRTLFKQLVSAVEYIHSKGVVHRDIKCENLLLDE 209

Mouse   189 DMNIKIADFGFSNEFT-------VGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTL 246
            :.|:|:.||||:.:.|       :.||  |||||..||:||:.:|..||....|:|:.||:.|.:
  Fly   210 NWNLKLIDFGFARKDTRTSDNQVILSK--TFCGSYAYASPEILKGVAYDPFMSDIWACGVVCYAM 272

Mouse   247 VSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLLKRFLVLNPVK-RGTLEQIMKDRW 306
            |.|.||:||.|:..|.:|:   ...:.|    ..|::|::::..  :|.||| |..:.|:.:|.|
  Fly   273 VFGRLPYDGSNVHILLKRI---NQSLVFPKSPSASSECKHMIMH--ILAPVKIRYNIPQVKEDPW 332

Mouse 307 306
Fly 333 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mark3	XP_006515574.1	STKc_MARK	55..307	CDD:270974	104/260 (40%)
		UBA_MARK3_4	325..367	CDD:270590
		MARK1-3_C	707..804	CDD:213381
CG9222	NP_608999.2	STKc_TSSK4-like	75..333	CDD:271064	104/260 (40%)
CG9222	NP_608999.2	S_TKc	78..332	CDD:214567	103/258 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910