DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tol-1 and Fili

DIOPT Version :9

Sequence 1:	NP_001020983.1	Gene:	tol-1 / 171635	WormBaseID:	WBGene00006593	Length:	1221	Species:	Caenorhabditis elegans
Sequence 2:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	125/563 - (22%)
Similarity:	229/563 - (40%)	Gaps:	121/563 - (21%)

- Green bases have known domain annotations that are detailed below.

Worm   139 EDV---LMPLARLEKFSLTRSRNIELPQRLLCSLP---HLQVLNISSNELPSLRREESCVAQQLL 197
            |||   |.|..:....::.|.|.:|.      |||   .|::|::|.|.:.:|..:......:|.
  Fly    65 EDVPIQLNPETKYINLTVNRIRTLEF------SLPFYMKLEILDLSQNIIETLGSKNFEYQSELR 123

Worm   198 IVDLSRNRLTNIEQFLRGIPAIRQISVAYNSIAELDLSLATPFLQQLDAEANRIVDLTSLPGTVV 262
            .::||||.::::.:.            |:..:..|.|         ||...|||        ..|
  Fly   124 TLNLSRNLVSSLHKH------------AFKGLTNLLL---------LDLSFNRI--------ETV 159

Worm   263 HVNLAGNALKRVPDAVAELASLVALNVSRNEIEAGNSSVFSSPE-LEMLDASYNKLDSLPVE--W 324
            |           |.|:::|||||.|:::.|.|.:...:.|.... ||:|....|:|..:|..  |
  Fly   160 H-----------PTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLW 213

Worm   325 LQKCEKRIAHLHLEHNSIEQLTGGVLANATNLQTLDLSSNQLRVFRDEVLPENSKIGNLRLSNNS 389
                     |||.                  |::||:|.|.:...|::......::..|.:..|.
  Fly   214 ---------HLHA------------------LKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNV 251

Worm   390 LELLEPSSLSGL-KLESLDLSHNKLTEVPA-AIGKVEQLKKVDLSHNRIAKVYQYVLNKIKQLHT 452
            :..|:.|:..|| .|:.||||.|.||.||. .:.|:..|..::|..||.:::.......:..|..
  Fly   252 MSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRE 316

Worm   453 VDLSN-NQLQSIGPYIFSDSSELHSLDVSNN-EISLLFKDAFARCPKLRKISMKMNKIKSLDEGL 515
            :.||. :.||.|....|.|::.|.:|.::|| ::|.:....|...|.:.::.|:.|.:::|....
  Fly   317 LHLSRLDFLQRIDSRAFVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQ 381

Worm   516 TEASGLRRLDVSHNEI-----LVLKWSALPENLEILN-----------------ADNNDI--NLL 556
            .....|::|.:..|.:     |:..|..:..|.|.::                 ||:.::  ...
  Fly   382 FPVDQLQKLYLGDNPLQCNCSLLWLWRLVTGNFEGVDPGMEHAAGGAVAALAKEADDEELADEAT 446

Worm   557 TAASMSPSTANLKSVSLSNNGITIMNADQIPNSLESLDVSNNR---LAKLGKTALAAKSQLRRLN 618
            ..||.....|.|.:.....:.:..::..: |::.|....|:||   :.::.:..:.......::.
  Fly   447 AVASTDDGVAALAAYIAEQHIVNALHTTE-PSAYELATSSSNRNSGILRMDRQQIGCDIWRDKVR 510

Worm   619 LKGNLLTVVATESMKVVEAVHPLKVEISENPLICDCQMGWMIG 661
            .:..|||:...|   :....|.:.|..:    :..|.:..|||
  Fly   511 TRRKLLTMSEGE---ITCPAHIVTVVCA----VITCLLVAMIG 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tol-1	NP_001020983.1	leucine-rich repeat	71..95	CDD:275380
		leucine-rich repeat	96..119	CDD:275380
		leucine-rich repeat	120..171	CDD:275380	11/37 (30%)
		leucine-rich repeat	172..195	CDD:275380	5/22 (23%)
		leucine-rich repeat	196..283	CDD:275380	18/86 (21%)
		leucine-rich repeat	219..240	CDD:275378	3/20 (15%)
		leucine-rich repeat	241..258	CDD:275378	5/16 (31%)
		LRR	265..600	CDD:227223	84/368 (23%)
		leucine-rich repeat	287..306	CDD:275380	4/18 (22%)
		leucine-rich repeat	307..331	CDD:275380	7/25 (28%)
		leucine-rich repeat	332..355	CDD:275380	3/22 (14%)
		leucine-rich repeat	356..379	CDD:275380	6/22 (27%)
		leucine-rich repeat	380..395	CDD:275380	3/14 (21%)
		leucine-rich repeat	403..425	CDD:275380	11/22 (50%)
		leucine-rich repeat	426..449	CDD:275380	4/22 (18%)
		leucine-rich repeat	450..473	CDD:275380	8/23 (35%)
		leucine-rich repeat	474..497	CDD:275380	6/23 (26%)
		leucine-rich repeat	498..520	CDD:275380	3/21 (14%)
		leucine-rich repeat	543..567	CDD:275380	5/42 (12%)
		leucine-rich repeat	568..589	CDD:275380	2/20 (10%)
		leucine-rich repeat	590..613	CDD:275380	4/25 (16%)
		leucine-rich repeat	614..633	CDD:275380	4/18 (22%)
		leucine-rich repeat	763..785	CDD:275378
		LRR_8	785..844	CDD:338972
		leucine-rich repeat	786..809	CDD:275378
		LRR_9	<806..>890	CDD:373143
		leucine-rich repeat	810..833	CDD:275378
		leucine-rich repeat	834..857	CDD:275378
		leucine-rich repeat	858..879	CDD:275378
		leucine-rich repeat	880..892	CDD:275378
		TIR_2	1056..1194	CDD:390066
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	6/27 (22%)
		leucine-rich repeat	98..121	CDD:275380	5/22 (23%)
		LRR_8	120..180	CDD:404697	24/99 (24%)
		leucine-rich repeat	122..145	CDD:275380	6/34 (18%)
		leucine-rich repeat	146..169	CDD:275380	12/50 (24%)
		LRR	<161..>354	CDD:227223	61/219 (28%)
		leucine-rich repeat	170..193	CDD:275380	6/22 (27%)
		leucine-rich repeat	194..217	CDD:275380	9/31 (29%)
		leucine-rich repeat	218..265	CDD:275380	12/46 (26%)
		leucine-rich repeat	266..289	CDD:275380	11/22 (50%)
		leucine-rich repeat	290..313	CDD:275380	4/22 (18%)
		leucine-rich repeat	314..338	CDD:275380	8/23 (35%)
		LRR_8	337..397	CDD:404697	13/59 (22%)
		leucine-rich repeat	339..360	CDD:275380	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010