Protein Alignment Man2b2 and LManII

DIOPT Version :9

• Sequence 1: NP_032576.2
• Gene: Man2b2 / 17160
• MGIID: 1195262
• Length: 1018
• Species: Mus musculus
• Sequence 2: NP_609408.1
• Gene: LManII / 34437
• FlyBaseID: FBgn0027611
• Length: 1080
• Species: Drosophila melanogaster
• Alignment Length: 1066
• Identity: 288/1066 - (27%)
• Similarity: 466/1066 - (43%)
• Gaps: 212/1066 - (19%)

Mouse     6 WLPL---LGQLL------LLWPRAAQ-------PAGP--IRAFVVPHSHMDVGWVFTVQE----- 47
            ||..   ||.|:      .:.|:|:|       |..|  :...:|.|:|.||||:.||.:
  Fly     8 WLVFFCALGCLIHDADLRSIQPKASQCGYQSCHPTKPNMLNVHLVAHTHDDVGWLKTVDQYYYGS 72

Mouse    48 ---SMRAYAANVYTTVVAELVRGGQRRFIAVEQEFFRLWWDGVASEQQ---KQQVRQLLHEGRLE 106
               ..:|....:..:||..|:|..::|||.||..||..||    .||:   ::.|:.|:.:||||
  Fly    73 ETKIQKAGVQYIIDSVVEALLRDPEKRFIYVESAFFFKWW----KEQKPKVQEAVKMLVEQGRLE 133

Mouse   107 FVLGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGI--RPQFSWHVDPFGASATTPTLFALAGFN 169
            |:.|...|:|||.||....|.|.:.|...|.:|||.  ||:..|.:||||.|....::||..||:
  Fly   134 FIGGAWSMNDEATTHYQSVIDQFSWGLRLLNDTFGECGRPRVGWQIDPFGHSREMASMFAQMGFD 198

Mouse   170 AHLISRIDYDLKDAMQEAQMLQFVWHGSPSLSGQQEIFTHVMDHYSYCTPSHIPFSNRSGFYWNG 234
            .....|:||..||.....:..:.:||||.:|..:.::|:..: :.:|..|        .||.::
  Fly   199 GMFFGRLDYQDKDERLMTKNAEMIWHGSANLGEEADLFSGAL-YNNYQAP--------DGFCFD- 253

Mouse   235 VAVFPEPPPDGVYP---NMSEPVTGANIHLYAEALVANVKQRAAWFRTPHVLWPWGCDKQFFNAS 296
            :.....|..||.:.   |:.|.:         :..:...|.::.::||.:::...|.|..:..|.
  Fly   254 ILCNDAPIIDGKHSPDNNVKERI---------DTFLDFAKTQSQYYRTNNIIVTMGGDFTYQAAQ 309

Mouse   297 VQFDNMDPLLDYINQRTAQ-FGISVQYATLNDYFQALHATNMTWGIRDHQDFLPYSSEPLQAWTG 360
            |.:.|:|.|:.|.|:|.|. ..|::.|:|.:.|.::||...:||..:. .||.||:|:|...|||
  Fly   310 VYYKNLDKLIRYGNERQANGSNINLLYSTPSCYLKSLHDAGITWPTKS-DDFFPYASDPHAYWTG 373

Mouse   361 FYTSRSTLKGLARQASALLYAGESMFTRYMWPDPSGTLDPTWALQQLQQLRWAVSEVQHHDAITG 425
            ::|||.|||...|..:..|...:.:..  :.|......||     .|..:|..:..:||||||||
  Fly   374 YFTSRPTLKRFERDGNHFLQVCKQLSA--LAPKKPEEFDP-----HLTFMRETLGIMQHHDAITG 431

Mouse   426 TESPKVKNMYTEHLRMGMLG----VRKLMVSIALGGPPGSGTGAPKDIMGPQVTPVLSVDTRPVG 486
            ||..||...|.:.:.:....    .|..:..:.:.........:.|.:...:...:|::.:.||.
  Fly   432 TEKEKVALDYAKRMSVAFRACGATTRNALNQLTVQSKDNVKDTSAKYVFEFKTCALLNITSCPVS 496

Mouse   487 -----YSASVYNPLAWKITTIITLTVAFPNVSVTDELGHPVSTQI------------QNSTKDPS 534
                 ::.::|||||..:...:.:.|.:.|..:.|..|..:.:|.            :|||   :
  Fly   497 EANDRFALTLYNPLAHTVNEYVRIPVPYSNYRIIDNKGVTLESQAVPIPQVLIDIKHRNST---A 558

Mouse   535 AYDLLIL-TTIPGLNYRHYQVMHARGDQAGTRELVAPRANTLKFSLKLRNQPSQEGKRLVPVMND 598
            .|:::.| |.||.|.||.|.|......:..||....|:..:                 .|.|:.:
  Fly   559 KYEIVFLATNIPALGYRTYYVEKLDSTEGNTRSKALPKRTS-----------------SVTVIGN 606

Mouse   599 CYILLFDQDTNMLHSIQDRQSNRTVRMTQEFLEYQANWDVKQGPISDN----------YLFAPN- 652
            .:|.|.......|..:......|.|  :||||.|       :|.:.:|          |:|.||
  Fly   607 SHIQLGFDTNGFLSEVTADGLTRLV--SQEFLFY-------EGAVGNNAEFLNRSSGAYIFRPNE 662

Mouse   653 NTAEPSWEAVGMEMVAGTLVTDIRQYFYRYITDQEYIYSIHTRLAHPSLAGELLCQRIEQQYRVG 717
            |....:.:.|.:|:..|.||.::.|.|..:|:....:|:      ..|.|        |.::.||
  Fly   663 NKIHFATDQVEIEVYKGDLVHEVHQKFNDWISQVVRVYN------KDSYA--------EFEWLVG 713

Mouse   718 PLDLN----REAILRTSSDLNSQQVLYSDNNGYQMQRRPYK-----AFKSN-PIPRNYYPMVQSA 772
            |:.::    :|.|.|.:||:.|..:..:|:||.:|.:|...     :.|.| .:..||||:....
  Fly   714 PIPIDDGIGKEVITRFNSDIASDGIFRTDSNGREMIKRKINHRDTWSVKINEAVAGNYYPITTKI 778

Mouse   773 FIEDDKSRLVLLAERPHGVSSQGNGQVEVMLHRRLWNNLAWDLKYNLTLNDTS-----IVHPVLW 832
            .:|||.:|:.:|.:|..|.||..:|.:|:|:||||..:.|:.:  ...||:|.     |......
  Fly   779 DVEDDTARMAILTDRAQGGSSLKDGSLELMVHRRLLKDDAFGV--GEALNETEYGDGLIARGKHH 841

Mouse   833 LMLGPKSTMTALHPRSGVALQHGPVVLLKEL-----------------ADE-ETPVHGPHNPWPV 879
            |..| |||     .|.||:|:  .:..|.:|                 ||| :|......:...:
  Fly   842 LFFG-KST-----DREGVSLK--GIERLTQLEKLLPTWKFFSNMEDYSADEWQTAFTNIFSGISL 898

Mouse   880 TLPPNLHLQILSVPGWTYSRSHAQHLRNLQRGHPEKPQANLQRVLLRLRHLYEAGEDPVLSRPAT 944
            .||..:||  |::..|     |...|                  |:|..|:.|.|||...|:|..
  Fly   899 VLPKPVHL--LTLEPW-----HENQL------------------LVRFEHIMENGEDASYSQPVQ 938

Mouse   945 VDLKVVLRGLGSVVAVEERSLTG-TW 969
            .::|.||... .|..:.|.:|.| .|
  Fly   939 FNVKNVLSAF-DVEGIRETTLDGNAW 963

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Man2b2	NP_032576.2	GH38N_AMII_Epman_like	27..352	CDD:212122	104/341 (30%)
		Alpha-mann_mid	358..439	CDD:214875	29/80 (36%)
		Glyco_hydro_38C	491..1012	CDD:285047	138/537 (26%)
LManII	NP_609408.1	GH38N_AMII_LAM_like	47..323	CDD:212121	89/298 (30%)
		Alpha-mann_mid	370..445	CDD:214875	29/81 (36%)
		Glyco_hydro_38C	502..957	CDD:285047	135/533 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910