DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Man2b1 and LManIII

DIOPT Version :9

Sequence 1:	XP_006530810.1	Gene:	Man2b1 / 17159	MGIID:	107286	Length:	1024	Species:	Mus musculus
Sequence 2:	NP_001285762.1	Gene:	LManIII / 34203	FlyBaseID:	FBgn0032066	Length:	1003	Species:	Drosophila melanogaster

Alignment Length:	1036	Identity:	408/1036 - (39%)
Similarity:	585/1036 - (56%)	Gaps:	126/1036 - (12%)

- Green bases have known domain annotations that are detailed below.

Mouse    47 ARAAGYKTCPPTKPGMLNVHLLPHTHDDVGWLKTVDQYYYGMDLDFLNFMPTVLSDVQHASVQYI 111
            :.|..|::||.||..|:|:||:||:|||:||||||||||||..           .::|||.||||
  Fly    21 SEAVCYESCPETKSNMINIHLVPHSHDDLGWLKTVDQYYYGNK-----------HNIQHAGVQYI 74

Mouse   112 LDSVVSSLLEKPTRRFIYVEMAFFSRWWKQQTSATQDAVRNLVRQGRLEFVNGGWVMNDEAATHY 176
            .|:||:.|.:...||||.||..||::||:.|:...:..|:.||.:|||||..|.|.||||||.:|
  Fly    75 FDTVVAELSKDSRRRFIQVETGFFAKWWEDQSETKKKLVKTLVNEGRLEFTGGAWSMNDEAAVNY 139

Mouse   177 GAIVDQMTLGLRFLQDTFGSDGLPRVAWHIDPFGHSREQASLFAQMGFDGFFLGRIDYQDKLNRK 241
            .:::||..:||:||.|.||..|.|||.|.||.|||||||||:||||.|||.|..|:|..||..|.
  Fly   140 QSVIDQFAVGLKFLNDNFGVCGRPRVGWQIDAFGHSREQASMFAQMAFDGQFFARMDQNDKNKRV 204

Mouse   242 KKLRMEELWRASDSLEPPAADLFTGVLPNNYNPPKYLCWDVLCTDPPVVDNPRSPEFNAKTLVNY 306
            ..|.:|.:|.||::||  ..|.|||:|.|:|:.|...|:|.||.|.|::|. :|.:.|.|:.|:.
  Fly   205 DNLGLEMVWDASETLE--EMDFFTGMLYNHYSAPPGFCFDSLCQDDPIIDG-KSYDNNVKSRVDD 266

Mouse   307 FLKLASSQKGFYRTNHTVMTMGSDFHYENANMWFKNMDKLIRLVNAQQVNGSLVHVLYSTPTCYL 371
            ||..||:..|:||:||.::.||.||.||||.|.:|||||||:.||.:|.:||..::.|||..|||
  Fly   267 FLNYASNLAGYYRSNHIMVPMGDDFQYENAYMNYKNMDKLIKYVNERQASGSKYNIFYSTAGCYL 331

Mouse   372 WELNKANLTWTVKEDDFFPYADGPHMFWTGYFSSRPALKRYERLSYNFLQVCNQLEALV---GPE 433
            ..|:|:..::..|..||.|::.....||||:|:|||..||:||...:.|||..||..|.   |.|
  Fly   332 NSLHKSLQSFPNKTQDFLPHSHEAKSFWTGFFTSRPTQKRFERDGNHILQVAKQLSVLADLSGEE 396

Mouse   434 ANVGPYGSGDSAPLQEAMAVLQHHDAVSGTARQNVVNDYARQL-AAGWGPCEVLVSNALARLSHY 497
            .:      .|...|::.|||:|||||::||.:|.|.|||.|.| .|..|.... ..:||..|::.
  Fly   397 QH------KDLDYLRQIMAVMQHHDAITGTEKQEVSNDYDRLLYDAILGGANT-ARDALRVLTNQ 454

Mouse   498 KQ-NFSFCRELNISICP-VSQTSERFQVTLYNPLGRKVDQMVRLPVYEGNFIVKDPHDKNISSNV 560
            .. .|..|.:||||.|. ..:.::.|.|||||||.....|.||:||.|.::.|.|.....::|.:
  Fly   455 PNGEFQSCLKLNISECAFTKENADDFMVTLYNPLAHTSTQYVRVPVKEDSYQVTDEKGGLVASEL 519

Mouse   561 VMVP------SYYSETYQWELLFPASVPALGFSTYSVAKM---------------SDLNHQAHNL 604
            |.||      .:.:...|.||:|.|||..:  :||.:.|:               ..:|.:..|
  Fly   520 VPVPWEVLSLEFRNNDTQHELVFKASVNKI--ATYFIKKIDKTTEVDITVNTQTEQSVNEEESN- 581

Mouse   605 LSRPRKHKSHHVL------------VIENKYMRATFDSGTGLLMKIENLEQN-LSLPVSQGFFWY 656
            :..|::.|..|.|            :::|..::...|:.||   :::.:|.| :|..:.|.|..|
  Fly   582 VKVPKRFKKVHSLKTDLETLDDQETIVQNSLIKLVIDNNTG---RLKTVEMNGVSEDIDQTFGMY 643

Mouse   657 NASVGDEESSQASGAYIFRPNVGKPIPVSRWAQISLVKTAL---------VQEVHQNFSAWCSQV 712
            ..:        .|..||||.:          |.:.||:.|.         |:||||:.:.|.|||
  Fly   644 KTA--------RSCHYIFRQD----------ADLELVEDAFDFTVYDGESVKEVHQHVNEWISQV 690

Mouse   713 IRLYKGQRHLELEWTVGPIPVRDDWGKEVISRFDTPMKTKGQFFTDSNGREILKRRDDYRPTWTL 777
            ||:|:|...:|.||.|||:|:.|:.|||:::.|.:.:.:.|.|:|||||||:::|..|.|..::.
  Fly   691 IRIYEGVNRVEFEWLVGPVPIDDELGKEIVTIFKSGISSGGVFYTDSNGREMMRREKDKREDFSP 755

Mouse   778 NQTE-PVAGNYYPVNTRIYITDGQMQLTVLTDRSQGGSSLQDGSLELMVHRRLLVDDDRGVSEPL 841
            :.:| ||:||||||.:|:.:.|...::.:|.||||||:||:||.||:|:|||.:..|..|.:|.:
  Fly   756 DLSEQPVSGNYYPVTSRMALQDSSKRMVLLNDRSQGGASLEDGRLEMMLHRRHIFADGSGAAEAI 820

Mouse   842 LETDTGDKV--RGRHLVLLSSVSDAAARHRLLAEQEVLAPQVVLSLGGSSPYHSRATPKT--QFS 902
            .|...|..:  ||:..:.|:::.|.|.....:||:|:..| .......|:...|..| ||  .|:
  Fly   821 NEQQFGKGLIARGKLFLYLNAIEDGATASERVAEKEIHLP-FWKFFSKSNNIQSDVT-KTLSDFN 883

Mouse   903 GLRQELPPQVHLLTLARWGPKMLLLRLEHQFALKEDSDRNLSSPVTLNVQNLFQTFTINYLQETT 967
                :||..||||||..:....:|||||:..      |:...:.|:.:::.:|.......::|||
  Fly   884 ----DLPQSVHLLTLEPYSKDEILLRLENFL------DQTEGNVVSFSIRQIFDDLGGLEIRETT 938

Mouse   968 LAANQPLSRASRLKW-MTNTGP--------TSYPEPSKLDPT------SVTLKPMEIRTFL 1013
            |..|.|||...|||: ...:||        ||..:|...|.|      |||||||:||||:
  Fly   939 LDGNLPLSDMKRLKFHHDGSGPSHSVPEYFTSLHKPLAADKTQDASEFSVTLKPMQIRTFI 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Man2b1	XP_006530810.1	PLN02701	63..917	CDD:178304	362/907 (40%)
Man2b1	XP_006530810.1	GH38N_AMII_LAM_like	63..352	CDD:212121	149/288 (52%)
LManIII	NP_001285762.1	GH38N_AMII_LAM_like	37..311	CDD:212121	148/287 (52%)
		Alpha-mann_mid	358..433	CDD:286360	38/80 (48%)
		Glyco_hydro_38C	603..998	CDD:285047	147/427 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838002
Domainoid	1	1.000	82	1.000	Domainoid score	I8388
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4230
OMA	1	1.010	-	-		QHG55625
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm42625
orthoMCL	1	0.900	-	-		OOG6_101099
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1279
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.670