Protein Alignment Man2a1 and LManII

DIOPT Version :9

• Sequence 1: NP_032575.2
• Gene: Man2a1 / 17158
• MGIID: 104669
• Length: 1150
• Species: Mus musculus
• Sequence 2: NP_609408.1
• Gene: LManII / 34437
• FlyBaseID: FBgn0027611
• Length: 1080
• Species: Drosophila melanogaster
• Alignment Length: 1136
• Identity: 286/1136 - (25%)
• Similarity: 462/1136 - (40%)
• Gaps: 258/1136 - (22%)

Mouse   165 LQVFVVPHSHNDPGWLKTFNDYF--------RDKTQYIFNNMVLKLKEDSSRKFMWSEISYLAKW 221
            |.|.:|.|:|:|.|||||.:.|:        :...|||.:::|..|..|..::|::.|.::..||
  Fly    47 LNVHLVAHTHDDVGWLKTVDQYYYGSETKIQKAGVQYIIDSVVEALLRDPEKRFIYVESAFFFKW 111

Mouse   222 WDIIDIPKKEAVKSLLQNGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLEKNLGV--KPRSG 284
            |.......:||||.|::.|:||.:.|.|.|.||||.||.::|||...|.:.|....|.  :||.|
  Fly   112 WKEQKPKVQEAVKMLVEQGRLEFIGGAWSMNDEATTHYQSVIDQFSWGLRLLNDTFGECGRPRVG 176

Mouse   285 WAIDPFGHSPTMAYLLKRAGFSHMLIQRVHYAIKKHFSLHKTLEFFWRQNWDLGSATDILCHMMP 349
            |.|||||||..||.:..:.||..|...|:.|..|....:.|..|..|..:.:||...|:....:
  Fly   177 WQIDPFGHSREMASMFAQMGFDGMFFGRLDYQDKDERLMTKNAEMIWHGSANLGEEADLFSGAL- 240

Mouse   350 FYSYDIPH------TCGPDPKICCQFDFKRLPGGRYGCPWGVPPEAISPGNVQSRAQMLLDQYRK 408
            :.:|..|.      .|...|.|    |.|..|                ..||:.|....||..:.
  Fly   241 YNNYQAPDGFCFDILCNDAPII----DGKHSP----------------DNNVKERIDTFLDFAKT 285

Mouse   409 KSKLFRTKVLLAPLGDDFRFSEYTEWDLQCRNYEQLFSYMNSQP--HLKVKIQFGTLSDYFDALE 471
            :|:.:||..::..:|.||   .|....:..:|.::|..|.|.:.  ...:.:.:.|.|.|..:|.
  Fly   286 QSQYYRTNNIIVTMGGDF---TYQAAQVYYKNLDKLIRYGNERQANGSNINLLYSTPSCYLKSLH 347

Mouse   472 KAVAAEKKSSQSVFPALSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESRIRAAEILYQLALK 536
            .|        ...:|..|.|||.||.....||:|||||||..||.:|.....::..:.|..||.|
  Fly   348 DA--------GITWPTKSDDFFPYASDPHAYWTGYFTSRPTLKRFERDGNHFLQVCKQLSALAPK 404

Mouse   537 QAQKYKINKFLSSPHYTTLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFQSLNSLEKIIGDS 601
            :.:::       .||   ||..|..||:.|||||||||.|:.|.:||..|:..:..:......::
  Fly   405 KPEEF-------DPH---LTFMRETLGIMQHHDAITGTEKEKVALDYAKRMSVAFRACGATTRNA 459

Mouse   602 AFLLILKDKKLYQSDPSKAFLEMDT-KQSSQDSLPQKIIIQLSAQEPRY-LVVYNPFEQERHSVV 664
            ...|.::.|...:...:|...|..| ...:..|.|      :|....|: |.:|||.....:..|
  Fly   460 LNQLTVQSKDNVKDTSAKYVFEFKTCALLNITSCP------VSEANDRFALTLYNPLAHTVNEYV 518

Mouse   665 SIRVNSATVKVLSDSGKPVE---VQVSAVWNDMR-TISQAAYEVSFLA-HIPPLGLKVFKILESQ 724
            .|.|..:..:::.:.|..:|   |.:..|..|:: ..|.|.||:.||| :||.||.:.:.:.:..
  Fly   519 RIPVPYSNYRIIDNKGVTLESQAVPIPQVLIDIKHRNSTAKYEIVFLATNIPALGYRTYYVEKLD 583

Mouse   725 SSSSHLADYVLYNNDGLAENGIFHVKNMVDAGDAITIENPFLAIWFDRSGLMEKVRRKEDSRQHE 789
            |:..:.....|...                ......|.|..:.:.||.:|.:.:|  ..|.....
  Fly   584 STEGNTRSKALPKR----------------TSSVTVIGNSHIQLGFDTNGFLSEV--TADGLTRL 630

Mouse   790 LKVQFLWY--GTTNKRD----KSGAYLFLPDGQGQPYVSLRPPFVRVTRGRIYSDV-TCFLEHVT 847
            :..:||:|  ...|..:    .||||:|.|: :.:.:.:.....:.|.:|.:..:| ..|.:.::
  Fly   631 VSQEFLFYEGAVGNNAEFLNRSSGAYIFRPN-ENKIHFATDQVEIEVYKGDLVHEVHQKFNDWIS 694

Mouse   848 HKVRLYN------IQGIEGQSMEVSNIVNIRNVHNREIVMRISSKINNQNRYYTDLNGYQ----- 901
            ..||:||      .:.:.|.       :.|.:...:|::.|.:|.|.:...:.||.||.:
  Fly   695 QVVRVYNKDSYAEFEWLVGP-------IPIDDGIGKEVITRFNSDIASDGIFRTDSNGREMIKRK 752

Mouse   902 IQPRRTMS-KL--PLQANVYPMCTMAYIQDAEHRLTLLSAQSLGASSMASGQIEVFMDRRLMQDD 963
            |..|.|.| |:  .:..|.||:.|...::|...|:.:|:.::.|.||:..|.:|:.:.|||::||
  Fly   753 INHRDTWSVKINEAVAGNYYPITTKIDVEDDTARMAILTDRAQGGSSLKDGSLELMVHRRLLKDD 817

Mouse   964 NRGLGQGVH-----DNKITANLFRILLEK---RSAVNM-------EEEKKSPVSYPSLLSHM--- 1010
            ..|:|:.::     |..|......:...|   |..|::       :.||..|..  ...|:|
  Fly   818 AFGVGEALNETEYGDGLIARGKHHLFFGKSTDREGVSLKGIERLTQLEKLLPTW--KFFSNMEDY 880

Mouse  1011 -----TSSFLNHPFLPMVLSG---QLPSP------------------------------------ 1031
                 .::|.|      :.||   .||.|
  Fly   881 SADEWQTAFTN------IFSGISLVLPKPVHLLTLEPWHENQLLVRFEHIMENGEDASYSQPVQF 939

Mouse  1032 -------AFEL-------------LSEFPLLQ---------------SSLPCD-IHLVNLRTIQS 1060
                   ||::             |.|...||               .|.|.: :||::..  :.
  Fly   940 NVKNVLSAFDVEGIRETTLDGNAWLDESRRLQFAPDPEEAAFNTYATFSQPAESVHLLSAE--KP 1002

Mouse  1061 KMGKGYSDEAALILH--------RKGFDCQFSSRGIGLPCSTTQGKMSVLKLFNKFAVESLVPSS 1117
            .:|..|:|||.....        |:..:.:...:..|....:|:|.      :|.|
  Fly  1003 MLGVKYADEALPAGQLGAESNRIRRETETRQEKKDEGRSSKSTEGP------YNSF--------- 1052

Mouse  1118 LSLMHSPPDAQNMSE-VSLSPMEISTFRIRL 1147
                  ..|:.|... :.||||||.||.:.|
  Fly  1053 ------KSDSSNQEYIIELSPMEIRTFIVYL 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Man2a1	NP_032575.2	PLN02701	127..1148	CDD:178304	286/1136 (25%)
		GH38N_Man2A1	164..507	CDD:212131	110/359 (31%)
		Alpha-mann_mid	502..587	CDD:214875	36/84 (43%)
		Glyco_hydro_38C	757..1143	CDD:285047	105/513 (20%)
LManII	NP_609408.1	GH38N_AMII_LAM_like	47..323	CDD:212121	94/299 (31%)
		Alpha-mann_mid	370..445	CDD:214875	36/84 (43%)
		Glyco_hydro_38C	502..957	CDD:285047	103/488 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3970
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840