Protein Alignment Man2a1 and LManI

DIOPT Version :9

• Sequence 1: NP_032575.2
• Gene: Man2a1 / 17158
• MGIID: 104669
• Length: 1150
• Species: Mus musculus
• Sequence 2: NP_001260350.1
• Gene: LManI / 34436
• FlyBaseID: FBgn0032253
• Length: 950
• Species: Drosophila melanogaster
• Alignment Length: 1079
• Identity: 280/1079 - (25%)
• Similarity: 466/1079 - (43%)
• Gaps: 227/1079 - (21%)

Mouse   165 LQVFVVPHSHNDPGWLKTFNDYF---RDK-----TQYIFNNMVLKLKEDSSRKFMWSEISYLAKW 221
            :.|.:|||||:|.|||||.:.|:   ::|     .|||.:.:|.:|.:||||:|:..|..:.|||
  Fly     2 INVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAKW 66

Mouse   222 WDIIDIPKKEAVKSLLQNGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLEKNLG--VKPRSG 284
            :.......:.|||.|:..|:||...|.|.|.||||.||.:::||...|.::|:...|  .:|..|
  Fly    67 YSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTVG 131

Mouse   285 WAIDPFGHSPTMAYLLKRAGFSHMLIQRVHYAIKKHFSLHKTLEFFWRQNWDLGSATDILCHMMP 349
            |.|||||||..||.:..:..|:.....|:.|..||...|...:|..|:.:..|.: ::|...|:
  Fly   132 WQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIWQSSESLKN-SNIFTGML- 194

Mouse   350 FYSYDIPHTCGPDPKICCQFDFKRLP---GGRYGCPWGVPPEAISPGNVQSRAQMLLDQYRKKSK 411
            :..|..|      |..|...:.:..|   |..|            ..||.:|....:|..:..||
  Fly   195 YNHYSAP------PGFCFDINCEDAPIIDGESY------------DNNVDARVSEFIDYVKNMSK 241

Mouse   412 LFRTKVLLAPLGDDFRFSEYTEWDLQCRNYEQLFSYMNSQPHL--KVKIQFGTLSDYFDALEKAV 474
            .:|:..::.|:||||   :|.:..:..:|.::|..|:|.:...  :|.:.:.|.|.|...|.:.
  Fly   242 SYRSTHIMVPMGDDF---QYEDAAVNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQL- 302

Mouse   475 AAEKKSSQSVFPALSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESRIRAAEILYQLALKQAQ 539
                   :..:|..:.|||.|:.....||:|||||||..||..|......:..:.|..||.....
  Fly   303 -------KQTWPNKTEDFFPYSSDSHSYWTGYFTSRPTQKRFHRDGNHFFQTVKQLSVLANLSGT 360

Mouse   540 KYKINKFLSSPHYTTLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFQSLNSLEKIIGDSAFL 604
            :|       |.....|::|   :|:.|||||:|||.|..|..||...||:::...|....|:
  Fly   361 QY-------SEDLDNLSQA---MGIMQHHDAVTGTEKQAVASDYDRLLFKAIVGAENSARDA--- 412

Mouse   605 LILKDKKLYQSDPSKAFLEMDTK--QSSQDSLPQKIIIQLSAQEPRYLVVYNPFEQERHSVVSIR 667
              |:......|...::.||::..  ..:||:....|:           .:.||........|.:.
  Fly   413 --LRSLTNLTSGEFESCLELNISVCAFTQDTANNVIV-----------TLVNPLAHSSTQYVRVP 464

Mouse   668 VNSATVKVLSDSGK-------PVEVQVSAVW---NDMRTISQAAYEVSFLAHIPPLGLKVFKILE 722
            ..:....|..:.|:       ||..||.|:.   ||.:      :|:.|.|.:..:...:.::|.
  Fly   465 AKNENYIVTDEKGREVFSEVVPVPWQVLALEHRPNDTQ------HELVFEASVDKIANFLIRVLP 523

Mouse   723 SQSSSSHLADYVLYNNDGLAENGI-FHVKNMVDAGDAITIENPFLAIWFDRS--GLME-KVRRKE 783
            |..:              :||:.: |.|:.   :.|.:|:|...:.:.||.:  ||.. |:....
  Fly   524 SPKN--------------IAEDQVQFPVER---SQDELTVETSLVKLTFDTTTGGLKTVKMNGFT 571

Mouse   784 DSRQHELKVQFLWYGTT--NKRDKSGAYLFLPDGQGQPYVSLRPPFVRVTRGRIYSDVTCFLEHV 846
            ::.|....:...:.|..  :|...||||:|.|                      |.|:    |.|
  Fly   572 ENIQQTFGIYKGYRGNNGESKNRSSGAYVFRP----------------------YGDI----EIV 610

Mouse   847 THKVRLYNIQGIEGQSME------VSNIVNIRNVHNR------------------EIVMRISSKI 887
            .:||.|....|.:.:.:.      :|.::.|....||                  ||:.|.||.|
  Fly   611 NNKVELSFYNGTKVKEVHQHVNEWISQVIRIYEDVNRVEFEWLVGPIPTDDDVGKEIITRFSSNI 675

Mouse   888 NNQNRYYTDLNGYQIQPRR---------TMSKLPLQANVYPMCTMAYIQDAEHRLTLLSAQSLGA 943
            :::.::|||.||.:|..|.         .||: .:..|.||:.....:||.|.|:|||:.::.|.
  Fly   676 SSKGKFYTDSNGREILERERNQREHFTPDMSE-AISGNYYPVTGQISLQDDEKRITLLNDRAQGG 739

Mouse   944 SSMASGQIEVFMDRRLMQDDNRGLGQGVHDNKITANLFR-----ILLEKRSAVNMEEEKKSPVSY 1003
            :|:..|::|:.:.|||:.||..|:|:.:::.:....|..     ::|:   ||:.:..::
  Fly   740 TSLKDGELELMLHRRLLNDDAFGVGEALNETQYGTGLIARGKIYLILD---AVDGKPNQR----- 796

Mouse  1004 PSLLSHMTSSFLNHPFLPMVLSGQLPSPAFELLSEFPLLQSSLPCDIHLVNLRTIQSKMGKGYSD 1068
              ||.|...   .|.:.....|..:.|....::.:|    ..:|..:.|::|        :.||.
  Fly   797 --LLQHQLD---QHFWKFFSKSNGVASVNRNMIPDF----FGIPESVELLSL--------EPYSK 844

Mouse  1069 EAALI----LHRKGFDCQF-------SSRGIGLPCSTTQGKMSV--LKLFNKFAVESL--VPSSL 1118
            :..||    .:.:|....|       |..|..:..:|..|.|.:  :|.| |||.:..  :|||:
  Fly   845 DQILIRLENFNTEGNVVSFNIYPLFESLDGYQIWETTLDGNMLLEDVKRF-KFAQDGTGSIPSSV 908

Mouse  1119 SLMHSPPD------AQNMS--EVSLSPMEISTFRIRLRW 1149
            ...|:|.:      ..|.|  .|:|.||:|.||.|:.::
  Fly   909 EYYHAPHNPLTANSTMNASGFVVTLVPMQIRTFIIQQKY 947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Man2a1	NP_032575.2	PLN02701	127..1148	CDD:178304	280/1076 (26%)
		GH38N_Man2A1	164..507	CDD:212131	109/356 (31%)
		Alpha-mann_mid	502..587	CDD:214875	32/84 (38%)
		Glyco_hydro_38C	757..1143	CDD:285047	107/451 (24%)
LManI	NP_001260350.1	GH38N_AMII_LAM_like	2..276	CDD:212121	95/296 (32%)
		Alpha-mann_mid	323..398	CDD:286360	32/84 (38%)
		Glyco_hydro_38C	536..941	CDD:285047	108/460 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810