Protein Alignment Man1a and alpha-Man-Ib

DIOPT Version :10

• Sequence 1: XP_006512631.1
• Gene: Man1a / 17155
• MGIID: 104677
• Length: 746
• Species: Mus musculus
• Sequence 2: NP_651667.1
• Gene: alpha-Man-Ib / 43436
• FlyBaseID: FBgn0039634
• Length: 685
• Species: Drosophila melanogaster
• Alignment Length: 714
• Identity: 219/714 - (30%)
• Similarity: 349/714 - (48%)
• Gaps: 106/714 - (14%)

Mouse    92 MPVGGLLPLFSSPGGGGLGSGLGGGLGGGRKGSGPAAFRL--TEKFVLLLVFSAF---ITLCFGA 151
            |..||.:.|...||......      ..|||....|..:|  .::.:::|..:.|   :.||...
  Fly     1 MKDGGHITLTLPPGSAATTD------ERGRKSLRRAWNQLPRCQRNLIILGITGFCVTVLLCLSG 59

Mouse   152 IFFLPDSSK---LLSGVLFHSNPALQPPAEHKPGLGARA-EDAAEGRVRHREEGAPGDPGA---- 208
            ...|..|.|   ..:.|..:..|.  |...|.||:.... :|.|...|       |.|..|
  Fly    60 DQLLAASLKDVDTKAEVAAYQMPL--PNPHHHPGVDKDVPKDTAAVPV-------PADKRAPRVE 115

Mouse   209 GLEDNLARIRENHERALREAK--ETLQKLPEEIQRDILLEKEKVA-----QDQLRDKDLFRGLPK 266
            .:.|..     |...|..||.  |.:.:|||.:..:.|.:...:|     .|..:::|    :..
  Fly   116 AVSDKF-----NELVAYGEANSAENVARLPETVAAEGLPQASAMAVALPPPDSNKEQD----IGG 171

Mouse   267 VDFL----PPVGVENREP-----------------ADATIREKRAKIKEMMT------------- 297
            :|.|    .||..:..||                 ...:.:|...|||.::.
  Fly   172 IDILNNVEEPVAQDPAEPLSEGEQLEQAIKNPLTLGGVSFKEHLKKIKPILAKGQHFHGATNERQ 236

Mouse   298 --------HAWNNYKRYAWGLNELKPISKEGHSSSLFGNIKGATIVDALDTLFIMGMKTEFQEAK 354
                    |:|..||:||||.:.|||||:..|  ..||  .|.||||:|||::|||:..||:|.:
  Fly   237 SAVVAAFKHSWAGYKKYAWGHDNLKPISQYSH--EWFG--LGLTIVDSLDTMYIMGLDDEFKEGR 297

Mouse   355 SWIKKYLDFNVNAEVSVFEVNIRFVGGLLSAYYLSGEEIFRKKAVELGVKLLPAFHTPSGIPWAL 419
            .|:::.|.|:...:|::|||.||.:|||||||:|||:.:|..||.|||.:|||||.:||.||::.
  Fly   298 DWVEQSLRFDTKRDVNLFEVTIRVLGGLLSAYHLSGDTMFLAKAAELGNRLLPAFQSPSNIPYSD 362

Mouse   420 LNMKSGIGRNWPWASGGSSILAEFGTLHLEFMHLSHLSGDPVFAEKVMKIRTVLNKLDKPEGLYP 484
            :|:......:..|:...|:  :|..|:.|||..||..:...::.:...|:...::.|:|..||.|
  Fly   363 VNLGDLSAHSPKWSPDSST--SEVTTIQLEFRDLSRSTNISIYEQVAHKVNEKVHDLEKNHGLVP 425

Mouse   485 NYLNPSSGQWGQH-HVSVGGLGDSFYEYLLKAWLMSDKTDLEAKKM-YFDAVQAIETHLIRKS-S 546
            .::|.::|.:..: .:|:|..|||:||||||.|:.:.:.|.:...: |..||..:.|.|:|:: .
  Fly   426 IFINANTGTFRNYATISLGARGDSYYEYLLKQWIQTGRKDNDNLILDYMQAVDGVLTQLMRRTPR 490

Mouse   547 GGLTYIAEWKGGL-LEHKMGHLTCFAGGMFALG-ADGAPEARAQHYLELGAEIARTCHESYNRTY 609
            ....||.|...|. .:.||.||||:..|...|| .:|.|::    :|.|..::..||:::|....
  Fly   491 EHWVYIGELINGKDFKPKMDHLTCYLPGTLILGHQNGMPDS----HLILARDLLDTCYQTYMMNP 551

Mouse   610 VKLGPEAFRF---DGGVEAIATRQNEKYYILRPEVIETYMYMWRLTHDPKYRTWAWEAVEALESH 671
            ..|..|...|   :...:.|..:.|:.:.:||||.:|:..|.:.:|.:..|:...|:..:|.|:|
  Fly   552 THLAAEISYFALTEKDDQDIYVKPNDAHNLLRPEFVESLYYFYSITGNRTYQDMGWKIFQAFETH 616

Mouse   672 CRVNGGYSGLRDVYIARES-YDDVQQSFFLAETLKYLYLIFSDD-DLLPLEHWIFNTEAHPFPI 733
            .:||.||:.:.:|...:.: ..|:.:||:::|||||.||:|||| ..:.||.|:||:|.||.|:
  Fly   617 AKVNAGYTSMGNVKNTQSTRLRDLMESFWMSETLKYFYLLFSDDRKEIDLEQWVFNSEGHPLPV 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Man1a	XP_006512631.1	Glyco_hydro_47	295..733	CDD:460241	165/468 (35%)
alpha-Man-Ib	NP_651667.1	Glyco_hydro_47	242..680	CDD:460241	165/447 (37%)