DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Magea2 and MAGE

DIOPT Version :9

Sequence 1:	NP_064400.1	Gene:	Magea2 / 17138	MGIID:	1333793	Length:	320	Species:	Mus musculus
Sequence 2:	NP_649702.2	Gene:	MAGE / 40860	FlyBaseID:	FBgn0037481	Length:	232	Species:	Drosophila melanogaster

Alignment Length:	222	Identity:	51/222 - (22%)
Similarity:	104/222 - (46%)	Gaps:	24/222 - (10%)

- Green bases have known domain annotations that are detailed below.

Mouse    73 PSEEASIKGSGGLEDPLYLLHNAQNTKVYDLVDFLVLNYQMKAFTTKAEMLESIG---REYEEYY 134
            ||:||        :.|:    :..:.||..:::: :|::..:....|.:.|.::.   .|.::..
  Fly    15 PSQEA--------QQPV----DVVDAKVRAILNY-ILDHTAQKIPIKDKDLIAVAGDKSELKKRL 66

Mouse   135 PLIFSEASECLKMVFGLDMVEVDPSVHSYILVTALGITYDGMMTDVLGMPKTGILIAVLSVIFMK 199
            ||:    :..|...||:.:..:|.:..::|......:.....:|.. ..|:..:|..:|..||::
  Fly    67 PLV----TNLLAETFGIILTPLDATTKTFICTAEEPVASIHELTPA-QRPQFTLLYIILMYIFLR 126

Mouse   200 GNYVSEEIIWEMVNNIGLCGGRD-PYIHKDPRKLISEEFVQEGCLKYR--QVPNSDPPSYGFLWG 261
            ||.:.:..::.|:..:.:....: .|...:.||.|.|.||::..||..  |:...|.....||||
  Fly   127 GNRIEDSKLYVMLEMLNIYPDEEHGYFGPNLRKQIEETFVKQQYLKRERSQLSAYDDSKTFFLWG 191

Mouse   262 PRAFAETSKMKVLQFFASINKTHPRAY 288
            |||.||.:..:::||.:.:...||:.:
  Fly   192 PRAKAEFTFEQMVQFASKLLNQHPKVF 218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magea2	NP_064400.1	MAGE_N	<44..78	CDD:372109	3/4 (75%)
Magea2	NP_064400.1	MAGE	134..271	CDD:366651	36/139 (26%)
MAGE	NP_649702.2	MAGE	36..201	CDD:279759	40/170 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842073
Domainoid	1	1.000	53	1.000	Domainoid score	I11275
eggNOG	1	0.900	-	-		E1_KOG4562
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I5107
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1195799at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42492
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11736
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.900