DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smad6 and Mad

DIOPT Version :9

Sequence 1:	NP_032568.3	Gene:	Smad6 / 17130	MGIID:	1336883	Length:	495	Species:	Mus musculus
Sequence 2:	NP_001259992.1	Gene:	Mad / 33529	FlyBaseID:	FBgn0011648	Length:	525	Species:	Drosophila melanogaster

Alignment Length:	391	Identity:	118/391 - (30%)
Similarity:	176/391 - (45%)	Gaps:	86/391 - (21%)

- Green bases have known domain annotations that are detailed below.

Mouse   179 SLLKRLKER--SLDTLLEAVESRGGVPGGCVLVPRA---DLRLGGQPAPPQLLLGRLFRWPDLQH 238
            ||:|:||:|  :::.|..|: |..|.|..||.:||:   .|::..:...|.::..|::||||||.
  Fly   120 SLVKKLKKRKGAIEELERAL-SCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQS 183

Mouse   239 AVELKPLCGCHSFTAAADGPTVCCNPYHFSRLCGPESPP---PPYSRLSP------------PDQ 288
            ..|||||..| .:..:|....||.||||:.|:..|..||   |.:|..:|            |..
  Fly   184 HHELKPLELC-QYPFSAKQKEVCINPYHYKRVESPVLPPVLVPRHSEFAPGHSMLQFNHVAEPSM 247

Mouse   289 ----------YKPLDLSDSTLSYTETEATNSLITAP--------------------------GEF 317
                      :....||.|..|.....:.||...:|                          |:.
  Fly   248 PHNVSYSNSGFNSHSLSTSNTSVGSPSSVNSNPNSPYDSLAGTPPPAYSPSEDGNSNNPNDGGQL 312

Mouse   318 SDASMSPDA----TKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGF----------C 368
            .||.|...|    ::|:.|.|:||:|...|||.::...:.:|.:       .||          |
  Fly   313 LDAQMGDVAQVSYSEPAFWASIAYYELNCRVGEVFHCNNNSVIV-------DGFTNPSNNSDRCC 370

Mouse   369 LGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGG-RALVVRKVP 432
            ||||:...|:.::..||..||.|:.|......|:|....:..|||.|...:...| ....|.|:|
  Fly   371 LGQLSNVNRNSTIENTRRHIGKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHHGFHPSTVCKIP 435

Mouse   433 PGYSIKVF-DFERSGLLQHA-----DAAHGPYDPHSVRISFAKGWGPCYSRQFITSCPCWLEILL 491
            ||.|:|:| :.|.:.||..:     :|.:......::|:||.||||..|.||.:||.|||:||.|
  Fly   436 PGCSLKIFNNQEFAQLLSQSVNNGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHL 500

Mouse   492 N 492
            :
  Fly   501 H 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smad6	NP_032568.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..115
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	133..161
		MH1_SMAD_6	161..274	CDD:199817	38/99 (38%)
		MH2_SMAD_6	323..493	CDD:199824	62/191 (32%)
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	38/97 (39%)
Mad	NP_001259992.1	MH2_SMAD_1_5_9	325..525	CDD:199822	61/184 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810