DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smad1 and Mad

DIOPT Version :9

Sequence 1:	NP_032565.2	Gene:	Smad1 / 17125	MGIID:	109452	Length:	465	Species:	Mus musculus
Sequence 2:	NP_001259992.1	Gene:	Mad / 33529	FlyBaseID:	FBgn0011648	Length:	525	Species:	Drosophila melanogaster

Alignment Length:	465	Identity:	350/465 - (75%)
Similarity:	383/465 - (82%)	Gaps:	32/465 - (6%)

- Green bases have known domain annotations that are detailed below.

Mouse     5 SLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQPSNCVTIPR 69
            |||||||||||:|||||||||||||||||||:|||||||:|||:||||:|||||||||.||||||
  Fly    89 SLFSFTSPAVKKLLGWKQGDEEEKWAEKAVDSLVKKLKKRKGAIEELERALSCPGQPSKCVTIPR 153

Mouse    70 SLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPV 134
            ||||||||||||||||||||||||||||||||||||||.|::||.:|||||||||||||||||||
  Fly   154 SLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLELCQYPFSAKQKEVCINPYHYKRVESPV 218

Mouse   135 LPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDS-FQQPNSHPFPHSPNSSYPNSPGG 198
            |||||||||||:.|.||:| ||.::.  ||.||.|.::.:| |   |||      :.|..|:..|
  Fly   219 LPPVLVPRHSEFAPGHSML-QFNHVA--EPSMPHNVSYSNSGF---NSH------SLSTSNTSVG 271

Mouse   199 SSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMA---QDGSQPMDTNMMAPPLPAEISRGDV 260
            |.|:     .:|:|.||:...|.||||||.|.||..:   .||.|.:|..|           |||
  Fly   272 SPSS-----VNSNPNSPYDSLAGTPPPAYSPSEDGNSNNPNDGGQLLDAQM-----------GDV 320

Mouse   261 QAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIEN 325
            ..|:|.||..|.||.|||||.||||.||.::.||:|||||:||||.:|.|||.||||||||||||
  Fly   321 AQVSYSEPAFWASIAYYELNCRVGEVFHCNNNSVIVDGFTNPSNNSDRCCLGQLSNVNRNSTIEN 385

Mouse   326 TRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQ 390
            ||||||||||||||.|||||||||||:||||||||||||||||:||||||.||||||||||||||
  Fly   386 TRRHIGKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHHGFHPSTVCKIPPGCSLKIFNNQEFAQ 450

Mouse   391 LLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMG 455
            ||:||||:|||.|||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly   451 LLSQSVNNGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMG 515

Mouse   456 SPHNPISSVS 465
            ||||.|||||
  Fly   516 SPHNAISSVS 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smad1	NP_032565.2	MH1_SMAD_1_5_9	9..132	CDD:199814	111/122 (91%)
		PRK10263	<133..>244	CDD:236669	51/114 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..246		33/87 (38%)
		MH2_SMAD_1_5_9	265..465	CDD:199822	174/199 (87%)
		L3 loop. /evidence=ECO:0000250\|UniProtKB:Q15797	418..428		9/9 (100%)
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	111/122 (91%)
Mad	NP_001259992.1	MH2_SMAD_1_5_9	325..525	CDD:199822	174/199 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	326	1.000	Domainoid score	I1183
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21196
Inparanoid	1	1.050	703	1.000	Inparanoid score	I659
Isobase	1	0.950	-	0.75	Normalized mean entropy	S660
OMA	1	1.010	-	-		QHG48637
OrthoDB	1	1.010	-	-		D274383at33208
OrthoFinder	1	1.000	-	-		FOG0000630
OrthoInspector	1	1.000	-	-		otm42592
orthoMCL	1	0.900	-	-		OOG6_103959
Panther	1	1.100	-	-	O	PTHR13703
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2797
SonicParanoid	1	1.000	-	-		X373
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.860