DRSC/TRiP Functional Genomics Resources

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Protein Alignment ZNF384 and dati

DIOPT Version :10

Sequence 1:NP_001372672.1 Gene:ZNF384 / 171017 HGNCID:11955 Length:608 Species:Homo sapiens
Sequence 2:NP_995596.1 Gene:dati / 43789 FlyBaseID:FBgn0262636 Length:1150 Species:Drosophila melanogaster


Alignment Length:672 Identity:155/672 - (23%)
Similarity:224/672 - (33%) Gaps:238/672 - (35%)


- Green bases have known domain annotations that are detailed below.


Human    77 TPHSQASVTQNITVVPVPSTGLMTAGVSCSQRWRREGSQSRGPGLVITSP----SGSLVTTASSA 137
            :|.:|..::.:.....||......|||      :.|| .:.|.|:|..:.    ||:..|..|.|
  Fly    81 SPPNQQPISHHALHHSVPQENEQLAGV------QPEG-PAAGSGVVGNNSSMAISGTNSTVGSKA 138

Human   138 QTFPI-------------------------------SAPMIVSALPPGSQALQ-VVPDLSKKVAS 170
            ::..|                               :|....:|:...|.|:| .:..:..:|.:
  Fly   139 ESSHIPQQHSEQQSYGSDSFRGTQSPQLSSHHLLFNAAAAAAAAVHLKSTAMQNNLSPIGDQVQN 203

Human   171 TLTEEGGGGGGGGGSVAPKPPRGRKKKRMLESGLPEMNDPYVLSPEDDDDH---------QKDGK 226
            .|...|.|.......:.||               .||:....|.|.|:..|         |..|.
  Fly   204 NLRNYGQGSLNALCGIKPK---------------QEMDAKTPLQPLDECPHPLVQAQAQSQYGGD 253

Human   227 TYR---------SEGNC---GTGNGQSLGLMDSVPGSTTNLLCDPG-------CRMCSLTFYSKS 272
            .|.         |||..   |.|...::...|:...:.::.|...|       |:..|......|
  Fly   254 YYDVADPQAREISEGRALIIGLGAPSTVSTDDAQSSAPSHQLAGTGRALQTHQCKPMSPGTVGSS 318

Human   273 EMQIHSKSHTETKPHKCPHCSKTFANSSYLAQHIRIHSG-------------------------- 311
            .:....:|...|       .||||:......||....||                          
  Fly   319 NLGAGRRSAPTT-------ISKTFSQGQQSPQHSTTPSGGSTTPDIKYNNDKMANEIQLQLSRSS 376

Human   312 -AKPYSCNFCEKSFRQLSHL-----------QQHTRIHSKMHTET--------------IKPHKC 350
             |...|....|:.:..|..|           ||..|:....|..|              .|||:|
  Fly   377 SAAAISERTLEECWSTLQRLFMHKSAMQQIQQQIPRVGLGTHGVTGSANLGGSITPSSDTKPHQC 441

Human   351 PHCSKTFANTSYLAQHLRIHSGAKPYNCSYCQKAFRQLSHLQQHTRIHTGDRPYKCAHPGCEKAF 415
            ..|.|:|::...|.||:|:|:|.|||.||||.:.|:||||:|||||:|||:|||||..|.|.:||
  Fly   442 QQCMKSFSSNHQLVQHIRVHTGEKPYKCSYCDRRFKQLSHVQQHTRLHTGERPYKCHLPDCGRAF 506

Human   416 TQLSNLQSHRRQHN------KDKPFKCHNCHRAYTDAASLEVHLSTHTVKHAKVY---------- 464
            .||||||.|.|.|:      |::||.|:.|.:.:...:||..|.|.....|..|.          
  Fly   507 IQLSNLQQHLRNHDAQVERAKNRPFHCNICGKGFATESSLRTHTSKELQLHLGVLQQHAALIGGP 571

Human   465 ---TCTICSRAYTSETYLMKHMR-----KHNPPDLQQQVQAAAAAAAVAQAQAQAQAQAQAQAQA 521
               :|.:|.:.:.....|:.||:     |..||.                              .
  Fly   572 NATSCPVCHKLFLGTEALVDHMKHVHKEKSPPPG------------------------------G 606

Human   522 QAQAQASQASQQQQQQQQQQQQQQQQPPPHFQSPGAAPQGGGGGDSNPNPPPQCSFD-------- 578
            .|.:|.|:.:|.                       ....|.|.|.||.....||:.:        
  Fly   607 SASSQFSELNQI-----------------------VTGNGNGTGSSNEQIATQCTTESNSHQATV 648

Human   579 --------LTPYKTAEHHKDIC 592
                    |...:||.|...:|
  Fly   649 GSSLIDSFLGKRRTANHPCPVC 670

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZNF384NP_001372672.1 C2H2 Zn finger 261..281 CDD:275368 3/19 (16%)
COG5048 <284..486 CDD:227381 86/277 (31%)
C2H2 Zn finger 289..309 CDD:275368 6/19 (32%)
C2H2 Zn finger 317..337 CDD:275368 6/30 (20%)
C2H2 Zn finger 350..370 CDD:275368 8/19 (42%)
C2H2 Zn finger 378..398 CDD:275368 14/19 (74%)
C2H2 Zn finger 406..428 CDD:275368 13/21 (62%)
C2H2 Zn finger 436..456 CDD:275368 6/19 (32%)
C2H2 Zn finger 466..486 CDD:275368 5/24 (21%)
datiNP_995596.1 C2H2 Zn finger 441..461 CDD:275368 8/19 (42%)
zf-H2C2_2 454..478 CDD:463886 14/23 (61%)
C2H2 Zn finger 469..489 CDD:275368 14/19 (74%)
zf-H2C2_2 481..508 CDD:463886 18/26 (69%)
C2H2 Zn finger 497..519 CDD:275368 13/21 (62%)
SUF4-like 502..>557 CDD:411020 21/54 (39%)
C2H2 Zn finger 502..530 CDD:411020 13/27 (48%)
C2H2 Zn finger 533..557 CDD:411020 6/23 (26%)
C2H2 Zn finger 533..557 CDD:275368 6/23 (26%)
C2H2 Zn finger 576..594 CDD:275368 4/17 (24%)
C2H2 Zn finger 667..687 CDD:275370 1/4 (25%)
C2H2 Zn finger 702..719 CDD:275370
Blue background indicates that the domain is not in the aligned region.

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