Protein Alignment ZNF384 and rn

DIOPT Version :10

• Sequence 1: NP_001372672.1
• Gene: ZNF384 / 171017
• HGNCID: 11955
• Length: 608
• Species: Homo sapiens
• Sequence 2: NP_001262343.1
• Gene: rn / 40879
• FlyBaseID: FBgn0267337
• Length: 952
• Species: Drosophila melanogaster
• Alignment Length: 740
• Identity: 210/740 - (28%)
• Similarity: 294/740 - (39%)
• Gaps: 187/740 - (25%)

Human     7 NSNPYFWPSIPTVSGQIENTMFINKMKDQLLPEKGCGLAPPHYPTLLTVPASVSLPSGISMDTES 71
            |:|.|.|.     :|.          .::::.....|....|..|..|.|...|.....|: :..
  Fly   161 NNNGYSWS-----TGN----------NNEVVSHSSNGHTNNHPTTPPTPPNEASATQATSV-SAI 209

Human    72 KSDQLTPHSQASVTQNITVVPVPSTGLMTAGVSCSQRWRREGSQSRGPGLVITSPSGSLVTTASS 136
            ..:|..|.||.......::...||........:|..:....|.......|...:|:.:|.:.:::
  Fly   210 NLNQAQPASQTRSNFGSSIKSPPSEPDAVTAATCKSQENNSGQNPTPNSLSDHNPAHNLNSNSTA 274

Human   137 AQTFPISAPMIVSALPPGSQALQ-----VVPDLSKKVASTLTEEGGGGGGGGG------------ 184
            |.....:|....:.:|.|....|     :|..:|..:|..:|.:.....|..|
  Fly   275 AAVAAAAAAAAAANMPIGGVQGQNPTQGLVHWMSAVMAEHMTGQTHHDPGAVGMHYMWNGNVDHA 339

Human   185 ------SVAPKPPRGRKK---------KRMLESGLPEMNDPYVLSPEDD---DDHQKDGKTYRSE 231
                  ::.|..||..:.         |:..|:   :|||.:..:.:..   ||::.:......:
  Fly   340 KDISDYNLWPPTPRSHQHASEHHPMSLKQEYEA---KMNDHHHNNLQKGHFLDDNRLEHHAVTGQ 401

Human   232 GNCGTGNGQSLGLMD---SVPGSTTNLLCDPGCRMCSLTFYSKSEMQIHSKSHTET--------- 284
            |..|.|....:|...   ||.|:::         :.:.:.::.:....|:::....
  Fly   402 GGLGLGASNGVGGGGGGASVVGNSS---------LGASSHHAVAAAHHHNQAVAAASAAALLVVP 457

Human   285 KPHKCPHCSKTFANSSYLAQHIRIHSGAKPYSCNFCEKSFRQLSHLQQHTRIHSKMHTETIKPHK 349
            :|............||....|.......:.|.|..|.:.|...:.||.||:||.:    ..||:|
  Fly   458 QPINASKMGGPGGVSSVAGGHATGGGSGRKYQCKMCPQIFSSKADLQLHTQIHMR----EAKPYK 518

Human   350 CPHCSKTFANTSYLAQHLRIHSGAKPYNCSYCQKAFRQLSHLQQHTRIHTGDRPYKCAHPGCEKA 414
            |..|||.|||:|||:||.|||.|.|||.|..||:.|.||||||||.|.||||:||||.||||:||
  Fly   519 CTQCSKAFANSSYLSQHTRIHLGIKPYRCEICQRKFTQLSHLQQHIRTHTGDKPYKCRHPGCQKA 583

Human   415 FTQLSNLQSHRRQHNKDKPFKCHNCHRAYTDAASLEVHLSTH-TVKHAKVYTCTICSRAYTSETY 478
            |:||||||||.|.|..||||||::|::.::|..||..|:..| ..||.|.:.|..|.::||.|||
  Fly   584 FSQLSNLQSHSRCHQTDKPFKCNSCYKCFSDEPSLLEHIPKHKESKHLKTHICQYCGKSYTQETY 648

Human   479 LMKHMRKH------NPPDLQQQVQAAAAAAAVA-------------------------------- 505
            |.|||:||      .||.:.....|.|||||.|
  Fly   649 LTKHMQKHAERTDKRPPIVPGSAAAIAAAAAAAAGGSANPANGPPPPPNPAQHQRNNLGLPPVSI 713

Human   506 ----------------------------QAQAQAQAQAQAQAQAQAQAQASQASQQ--------- 533
                                        |.|.|.|.|.|.|.|.|.|.||.....|
  Fly   714 APSDNGYWPKVSPDSAAAANAMEVMHQQQQQQQQQQQQQQQQQQQQQQQAHHHHPQHGVPPQQHV 778

Human   534 --QQQQQQQQQQQ----QQQPPP------HFQSPGAAPQG----GGGGDSNPN---PPP------ 573
              |||||||||||    ||||||      |:..| .||.|    |.|.:..|:   |.|
  Fly   779 PPQQQQQQQQQQQHHHPQQQPPPQHSMEAHYAQP-TAPNGSQSNGHGAELQPHHRMPDPVREDIA 842

Human   574 QCSFDLTPYKTAEHHKDICLTVTTS 598
            .....:.||..|.      :|.|||
  Fly   843 STPSAVGPYDAAS------ITKTTS 861

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZNF384	NP_001372672.1	C2H2 Zn finger	261..281	CDD:275368	1/19 (5%)
		COG5048	<284..486	CDD:227381	100/211 (47%)
		C2H2 Zn finger	289..309	CDD:275368	3/19 (16%)
		C2H2 Zn finger	317..337	CDD:275368	7/19 (37%)
		C2H2 Zn finger	350..370	CDD:275368	13/19 (68%)
		C2H2 Zn finger	378..398	CDD:275368	13/19 (68%)
		C2H2 Zn finger	406..428	CDD:275368	17/21 (81%)
		C2H2 Zn finger	436..456	CDD:275368	6/19 (32%)
		C2H2 Zn finger	466..486	CDD:275368	11/19 (58%)
rn	NP_001262343.1	C2H2 Zn finger	490..510	CDD:275368	7/19 (37%)
		C2H2 Zn finger	519..539	CDD:275368	13/19 (68%)
		COG5048	543..>647	CDD:227381	60/103 (58%)
		C2H2 Zn finger	547..567	CDD:275368	13/19 (68%)
		zf-H2C2_2	559..586	CDD:463886	21/26 (81%)
		C2H2 Zn finger	575..597	CDD:275368	17/21 (81%)
		C2H2 Zn finger	605..625	CDD:275368	6/19 (32%)
		C2H2 Zn finger	636..656	CDD:275368	11/19 (58%)