DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF721 and CG31441

DIOPT Version :9

Sequence 1:	NP_597731.2	Gene:	ZNF721 / 170960	HGNCID:	29425	Length:	923	Species:	Homo sapiens
Sequence 2:	NP_731558.1	Gene:	CG31441 / 326139	FlyBaseID:	FBgn0051441	Length:	341	Species:	Drosophila melanogaster

Alignment Length:	271	Identity:	76/271 - (28%)
Similarity:	129/271 - (47%)	Gaps:	32/271 - (11%)

- Green bases have known domain annotations that are detailed below.

Human   166 KCEECGKAFNRSTNLTAHKRIHNREKAYTGE------------------DRDRAFGWSTNLNEYK 212
            ||.|..|:|     :.|:::: .|:||...|                  |::.....:......:
  Fly    72 KCLEVHKSF-----MAANRKL-LRKKAIVDEELDKPDVEKLQQDLWDHTDQEMCVAMADTAGLLR 130

Human   213 KIHTGDKPYKCKECGKAFMHSSHLNKHEKIHTGEKPYKCKE---CGKVISSSSSFAKHKRIHTGE 274
            :.|..::  |.|:...|..:..:..:..::.|.|..: |:|   ...:||...|....||.....
  Fly   131 EDHNDNE--KAKDAEDATQNEKNQEEQVQVQTEEVEH-CQEQLHNMSIISKGVSARVPKRTKRNS 192

Human   275 KPFKCLECGKAFNISTTLTKHRRIHTGEKPYTCEVCGKAFRQSANLYVHRRIHTGEKPYTCGECG 339
            |.:.|.:||..|..||.|..|.:.|:|.||:.|::|...:.....:..||.:||..:||.|..|.
  Fly   193 KSWFCDQCGGVFKSSTYLKLHLQRHSGHKPFACDICQAKYYTDNEMRRHRILHTDARPYACRFCS 257

Human   340 KTFRQSANLYVHRRIHTGEKPYKCEDCGKAFGRYTALNQHKKIHTGEKPYKCEECGKAFNSSTNL 404
            ||:|..::..||.|.||.|:|::|:.|.|||...:...:|:.:||.::.|.||.|.:.|..|::|
  Fly   258 KTYRGCSSKVVHERTHTNERPFQCQHCDKAFTSTSTRQKHEMLHTNQRKYHCEICDQWFLRSSHL 322

Human   405 TAHK--RIHTR 413
            |.|:  ::|.|
  Fly   323 TLHQSTKLHQR 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF721	NP_597731.2	C2H2 Zn finger	83..103	CDD:275368
		COG5048	93..492	CDD:227381	76/271 (28%)
		C2H2 Zn finger	111..131	CDD:275368
		C2H2 Zn finger	139..159	CDD:275368
		zf-H2C2_2	151..176	CDD:290200	5/9 (56%)
		C2H2 Zn finger	167..187	CDD:275368	5/19 (26%)
		C2H2 Zn finger	223..243	CDD:275368	2/19 (11%)
		zf-H2C2_2	235..257	CDD:290200	4/24 (17%)
		C2H2 Zn finger	251..271	CDD:275368	7/22 (32%)
		C2H2 Zn finger	279..299	CDD:275368	8/19 (42%)
		zf-H2C2_2	292..316	CDD:290200	8/23 (35%)
		C2H2 Zn finger	307..327	CDD:275368	4/19 (21%)
		zf-H2C2_2	319..344	CDD:290200	10/24 (42%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		zf-H2C2_2	347..372	CDD:290200	12/24 (50%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		zf-H2C2_2	375..400	CDD:290200	8/24 (33%)
		C2H2 Zn finger	391..411	CDD:275368	8/21 (38%)
		COG5048	442..885	CDD:227381
		C2H2 Zn finger	447..467	CDD:275368
		C2H2 Zn finger	475..495	CDD:275368
		zf-H2C2_2	487..512	CDD:290200
		C2H2 Zn finger	503..523	CDD:275368
		zf-H2C2_2	516..540	CDD:290200
		C2H2 Zn finger	531..551	CDD:275368
		zf-H2C2_2	544..568	CDD:290200
		C2H2 Zn finger	559..579	CDD:275368
		zf-H2C2_2	571..596	CDD:290200
		C2H2 Zn finger	587..607	CDD:275368
		C2H2 Zn finger	615..634	CDD:275368
		C2H2 Zn finger	643..663	CDD:275368
		C2H2 Zn finger	671..691	CDD:275368
		zf-H2C2_2	683..708	CDD:290200
		C2H2 Zn finger	699..719	CDD:275368
		C2H2 Zn finger	755..775	CDD:275368
		zf-H2C2_2	767..789	CDD:290200
		C2H2 Zn finger	783..803	CDD:275368
		zf-H2C2_2	795..820	CDD:290200
		C2H2 Zn finger	811..831	CDD:275368
		zf-H2C2_2	824..848	CDD:290200
		C2H2 Zn finger	839..859	CDD:275368
		zf-H2C2_2	852..876	CDD:290200
		C2H2 Zn finger	867..887	CDD:275368
		C2H2 Zn finger	895..915	CDD:275368
CG31441	NP_731558.1	zf-AD	7..82	CDD:285071	5/14 (36%)
		COG5048	<174..337	CDD:227381	57/160 (36%)
		C2H2 Zn finger	197..217	CDD:275370	8/19 (42%)
		C2H2 Zn finger	225..245	CDD:275368	4/19 (21%)
		C2H2 Zn finger	253..273	CDD:275368	8/19 (42%)
		zf-H2C2_2	268..290	CDD:290200	12/21 (57%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		C2H2 Zn finger	309..328	CDD:275368	8/18 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000