DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cd180 and Fili

DIOPT Version :9

Sequence 1:	NP_032559.2	Gene:	Cd180 / 17079	MGIID:	1194924	Length:	661	Species:	Mus musculus
Sequence 2:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	327	Identity:	97/327 - (29%)
Similarity:	142/327 - (43%)	Gaps:	55/327 - (16%)

- Green bases have known domain annotations that are detailed below.

Mouse   303 LDLTATHLSELPSGLVGLSTLKKLVLSANKFENLCQISASNFPSLTHLSIKGNTKRL--ELGTGC 365
            ::||...:..|...|.....|:.|.||.|..|.|   .:.||...:.|.....::.|  .|....
  Fly    78 INLTVNRIRTLEFSLPFYMKLEILDLSQNIIETL---GSKNFEYQSELRTLNLSRNLVSSLHKHA 139

Mouse   366 LENLENLRELDLSHDDIETSDCCNLQLRNLSHLQSLNLSYNEPLSLKTEAFKECPQLELLDLAFT 430
            .:.|.||..||||.:.|||..  ...|.:|:.|..|:|:.|..:||:...||....||:|.....
  Fly   140 FKGLTNLLLLDLSFNRIETVH--PTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNN 202

Mouse   431 RLKVKDAQSPFQNLHLLKVLNLSHSLLDISSEQLFDGLPALQHLNLQGNHFPKGNIQKTNSLQTL 495
            ||....| |...:||.||.|::|.:|::......|:||..|..|::|||
  Fly   203 RLLDVPA-SNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGN---------------- 250

Mouse   496 GRLEILVLSFCDLSSIDQHAFTSLKMMNHVDLSHNRLTSSSIEALSHLKGI-YLNLASNRISIIL 559
                  |:|..|||     ||..|..:.|:|||.|.||....:.||.|..: ||||..||.
  Fly   251 ------VMSELDLS-----AFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRF---- 300

Mouse   560 PSLLPILSQQRTINLRQNPLDCTCSNIYFLEWYKENMQKLED---TEDTLCENPPLLRGVRLSDV 621
             |.||.::.....:||:..|    |.:.||       |:::.   .::|..:...|....:|||:
  Fly   301 -SQLPAVAFLNLFHLRELHL----SRLDFL-------QRIDSRAFVDNTHLQTLHLNNNPQLSDI 353

Mouse   622 TL 623
            .:
  Fly   354 PM 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cd180	NP_032559.2	leucine-rich repeat	38..57	CDD:275380
		LRR 1	54..75
		leucine-rich repeat	58..78	CDD:275380
		LRR 2	78..99
		leucine-rich repeat	79..102	CDD:275380
		LRR 3	102..123
		leucine-rich repeat	103..126	CDD:275380
		LRR 4	126..147
		leucine-rich repeat	127..150	CDD:275380
		LRR 5	150..171
		leucine-rich repeat	151..174	CDD:275380
		LRR 6	174..195
		leucine-rich repeat	175..201	CDD:275380
		LRR 7	201..221
		leucine-rich repeat	224..275	CDD:275380
		LRR 8	275..296
		leucine-rich repeat	276..299	CDD:275380
		LRR 9	299..321		4/17 (24%)
		leucine-rich repeat	300..322	CDD:275380	4/18 (22%)
		LRR_8	321..382	CDD:290566	19/62 (31%)
		LRR 10	322..343		7/20 (35%)
		leucine-rich repeat	323..346	CDD:275380	9/22 (41%)
		LRR_RI	345..>541	CDD:238064	60/197 (30%)
		LRR 11	346..366		3/21 (14%)
		leucine-rich repeat	347..371	CDD:275380	4/25 (16%)
		LRR_8	371..432	CDD:290566	22/60 (37%)
		LRR 12	371..391		9/19 (47%)
		leucine-rich repeat	372..397	CDD:275380	10/24 (42%)
		LRR 13	397..418		7/20 (35%)
		leucine-rich repeat	398..421	CDD:275380	8/22 (36%)
		LRR_8	420..481	CDD:290566	22/60 (37%)
		LRR 14	421..442		7/20 (35%)
		leucine-rich repeat	422..446	CDD:275380	8/23 (35%)
		LRR 15	446..466		5/19 (26%)
		leucine-rich repeat	447..470	CDD:275380	8/22 (36%)
		LRR 16	470..493		5/22 (23%)
		leucine-rich repeat	471..497	CDD:275380	5/25 (20%)
		LRR_8	497..555	CDD:290566	23/58 (40%)
		LRR 17	497..518		7/20 (35%)
		leucine-rich repeat	498..521	CDD:275380	8/22 (36%)
		LRR 18	521..544		9/22 (41%)
		leucine-rich repeat	522..545	CDD:275380	10/22 (45%)
		LRR 19	546..566		9/20 (45%)
		LRRCT	577..626	CDD:214507	10/50 (20%)
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	4/18 (22%)
		leucine-rich repeat	98..121	CDD:275380	9/25 (36%)
		LRR_8	120..180	CDD:404697	19/61 (31%)
		leucine-rich repeat	122..145	CDD:275380	4/22 (18%)
		leucine-rich repeat	146..169	CDD:275380	10/24 (42%)
		LRR	<161..>354	CDD:227223	71/236 (30%)
		leucine-rich repeat	170..193	CDD:275380	8/22 (36%)
		leucine-rich repeat	194..217	CDD:275380	8/23 (35%)
		leucine-rich repeat	218..265	CDD:275380	21/73 (29%)
		leucine-rich repeat	266..289	CDD:275380	10/22 (45%)
		leucine-rich repeat	290..313	CDD:275380	9/27 (33%)
		leucine-rich repeat	314..338	CDD:275380	7/34 (21%)
		LRR_8	337..397	CDD:404697	5/19 (26%)
		leucine-rich repeat	339..360	CDD:275380	4/17 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100