DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cd180 and Toll-4

DIOPT Version :9

Sequence 1:	NP_032559.2	Gene:	Cd180 / 17079	MGIID:	1194924	Length:	661	Species:	Mus musculus
Sequence 2:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster

Alignment Length:	704	Identity:	147/704 - (20%)
Similarity:	266/704 - (37%)	Gaps:	150/704 - (21%)

- Green bases have known domain annotations that are detailed below.

Mouse     9 FLVALFLASCRATTSSDQKCIEKEVNKTYN---------CENLGLNEIPGTLP---NSTECLEFS 61
            |:...:.:.|:.|...::.....:.|.:||         |....|..|| :||   ..:..|.|.
  Fly   352 FICEPYKSHCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQKNLTTIP-SLPVPKKGSSALVFQ 415

Mouse    62 FNVLPTIQNTTFSRLINLTFLDLTRCQIYWIHEDTF-QSQHRLDTLVLTANPLIFMAETALSGPK 125
            .|:|..:.:.:.....||..||::..|:..:..... :|.|.||   :..|.:     |.|| |:
  Fly   416 SNLLAELPDNSLEGYHNLKSLDVSYNQLTSLSVSQLPESLHYLD---IRHNKI-----TTLS-PQ 471

Mouse   126 ALKHLFFIQTGISSIDFIPLHNQKTLESLYLGSNHISSIKLPKGFPTEKLKVLDFQNNAIHYLSK 190
            .:::|:       |::....:..|.  |:|....|:......|. ...::|...|| ..:.|:..
  Fly   472 VVEYLY-------SVNVFNQYGNKW--SIYCDEYHLQEFFWYKA-KLLRIKTSKFQ-TIMEYIEL 525

Mouse   191 EDMSS------LQQATNLSLNLNGNDIA---GIELGAFDSAVFQSLNFGGTQNLLVIFKGLKNST 246
            ....|      :|....|.|..|.::|.   |.....|:..:.::||
  Fly   526 SSKGSFVENFFVQNIDQLYLEANEDEIIDAFGPSDKYFNLKLMEALN------------------ 572

Mouse   247 IQSLWL--GTFEDMDDEDI-SPAVFEGLC-------EMSVESINLQKHYFFNISSNTFHCFSGLQ 301
             .::||  |.|:::....: ||..:...|       |..:...||....:..:.::..:    ..
  Fly   573 -HAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPY----KT 632

Mouse   302 ELDLTATHLSELPSG----LVGLSTLKKLVLSANKFENL-CQISASNFPSLTHLSIKGN-TKRLE 360
            .|.|....:.:|.:.    :.|.:::.||.:|.|....| ..:...|   :|:|.::.| .|.|:
  Fly   633 TLYLDRNEIRKLTNTESLVVAGHASIHKLHMSQNLLRELPLHLLPEN---ITYLDVRNNLLKYLD 694

Mouse   361 LGT-GCLENLENLRELDLSHDDIETSDCCNLQLRN-LSHLQSLNLSYNEPLSLKTEAFKECPQLE 423
            .|. ..||..||:.:::||.:..|    ||.:.:. ||.|:.     :||:..:|
  Fly   695 DGVIAFLEYRENITKIELSGNPWE----CNCKAKAFLSFLRR-----HEPMEYET---------- 740

Mouse   424 LLDLAFTRLKVKDAQSPFQNLHLLKVLNLSHSL---LDISSEQLFDGLPALQHLNLQGNHFPKGN 485
                ...|:::.|.:.|...:..:...| |.||   :|.|.::|.: :|.|          |...
  Fly   741 ----VLRRVEITDDKCPEDCICCVDTSN-SDSLAYVVDCSGKELSE-IPQL----------PTPT 789

Mouse   486 IQKTNSLQTLGRLEILVLSFCDLSSIDQHAFTSLKMMNHVDLSHNRLTSSSIEALSHLKGIYLNL 550
            ..:|.          ||.....|.............:....|:||||  |.|:.|.. |..||::
  Fly   790 YGQTT----------LVFERNSLKKWPSSLLPGYSSVTRFYLAHNRL--SDIDQLPD-KLEYLDI 841

Mouse   551 ASNRISIILPSLLPIL-----SQQRTINLRQNPLDCTCSNIYFLEWYKENMQKLEDTEDTLC-EN 609
            ::|..|.:...:...|     |.|..::|..||..|.|.:..||.:.||..:.:.:.....| :.
  Fly   842 SNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNIANASAIQCIDT 906

Mouse   610 PPLLRGVRLSDVTLSCSMAAVGIFFLIVFLLVFAILLIFAVKY---FLRWKYQH 660
            ...|..|..:|:   |....:....|.|.||:.|:.:...:.:   .:.|.|:|
  Fly   907 GRSLIEVEETDI---CPSVLIYYTSLAVSLLIIALSINVFICFRQPIMIWFYEH 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cd180	NP_032559.2	leucine-rich repeat	38..57	CDD:275380	7/30 (23%)
		LRR 1	54..75		4/20 (20%)
		leucine-rich repeat	58..78	CDD:275380	4/19 (21%)
		LRR 2	78..99		5/21 (24%)
		leucine-rich repeat	79..102	CDD:275380	5/23 (22%)
		LRR 3	102..123		5/20 (25%)
		leucine-rich repeat	103..126	CDD:275380	7/22 (32%)
		LRR 4	126..147		2/20 (10%)
		leucine-rich repeat	127..150	CDD:275380	2/22 (9%)
		LRR 5	150..171		4/20 (20%)
		leucine-rich repeat	151..174	CDD:275380	4/22 (18%)
		LRR 6	174..195		4/20 (20%)
		leucine-rich repeat	175..201	CDD:275380	6/31 (19%)
		LRR 7	201..221		6/22 (27%)
		leucine-rich repeat	224..275	CDD:275380	10/60 (17%)
		LRR 8	275..296		2/20 (10%)
		leucine-rich repeat	276..299	CDD:275380	2/22 (9%)
		LRR 9	299..321		4/25 (16%)
		leucine-rich repeat	300..322	CDD:275380	4/25 (16%)
		LRR_8	321..382	CDD:290566	18/63 (29%)
		LRR 10	322..343		5/21 (24%)
		leucine-rich repeat	323..346	CDD:275380	6/23 (26%)
		LRR_RI	345..>541	CDD:238064	45/201 (22%)
		LRR 11	346..366		6/21 (29%)
		leucine-rich repeat	347..371	CDD:275380	8/25 (32%)
		LRR_8	371..432	CDD:290566	12/61 (20%)
		LRR 12	371..391		6/19 (32%)
		leucine-rich repeat	372..397	CDD:275380	6/25 (24%)
		LRR 13	397..418		4/20 (20%)
		leucine-rich repeat	398..421	CDD:275380	4/22 (18%)
		LRR_8	420..481	CDD:290566	12/63 (19%)
		LRR 14	421..442		3/20 (15%)
		leucine-rich repeat	422..446	CDD:275380	3/23 (13%)
		LRR 15	446..466		7/22 (32%)
		leucine-rich repeat	447..470	CDD:275380	7/25 (28%)
		LRR 16	470..493		3/22 (14%)
		leucine-rich repeat	471..497	CDD:275380	3/25 (12%)
		LRR_8	497..555	CDD:290566	15/57 (26%)
		LRR 17	497..518		3/20 (15%)
		leucine-rich repeat	498..521	CDD:275380	3/22 (14%)
		LRR 18	521..544		8/22 (36%)
		leucine-rich repeat	522..545	CDD:275380	8/22 (36%)
		LRR 19	546..566		4/19 (21%)
		LRRCT	577..626	CDD:214507	12/49 (24%)
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380	6/33 (18%)
		leucine-rich repeat	388..408	CDD:275380	6/20 (30%)
		LRR_8	412..465	CDD:290566	14/55 (25%)
		leucine-rich repeat	412..432	CDD:275378	4/19 (21%)
		LRR_4	432..470	CDD:289563	13/46 (28%)
		leucine-rich repeat	433..454	CDD:275378	4/20 (20%)
		leucine-rich repeat	455..478	CDD:275378	9/38 (24%)
		leucine-rich repeat	479..490	CDD:275378	1/12 (8%)
		leucine-rich repeat	632..657	CDD:275378	4/24 (17%)
		leucine-rich repeat	658..679	CDD:275378	5/20 (25%)
		leucine-rich repeat	680..706	CDD:275378	8/25 (32%)
		leucine-rich repeat	707..719	CDD:275378	3/15 (20%)
		leucine-rich repeat	771..791	CDD:275380	6/30 (20%)
		leucine-rich repeat	793..815	CDD:275378	4/31 (13%)
		leucine-rich repeat	816..835	CDD:275378	8/21 (38%)
		leucine-rich repeat	836..859	CDD:275378	5/22 (23%)
		TIR	974..1110	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910