DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khdrbs2 and how

DIOPT Version :9

Sequence 1:	NP_573498.1	Gene:	Khdrbs2 / 170771	MGIID:	2159649	Length:	349	Species:	Mus musculus
Sequence 2:	NP_001262822.1	Gene:	how / 42596	FlyBaseID:	FBgn0264491	Length:	418	Species:	Drosophila melanogaster

Alignment Length:	384	Identity:	113/384 - (29%)
Similarity:	169/384 - (44%)	Gaps:	100/384 - (26%)

- Green bases have known domain annotations that are detailed below.

Mouse     6 YLPELMAEKDSLD--PS-FVHASRLLAEEIEKFQGS----DGKKEDEEKKYLDVISNKNIKLSER 63
            ||.:|:.::..|.  |: |.|..|||.|||.:.:.|    :|.|  :|...|.......:.::|:
  Fly    78 YLAQLLKDRKQLAAFPNVFTHVERLLDEEIARVRASLFQINGVK--KEPLTLPEPEGSVVTMNEK 140

Mouse    64 VLIPVKQYPKFNFVGKLLGPRGNSLKRLQEETGAKMSILGKGSMRDKTKEEELRKSGEAKYAHLS 128
            |.:||:::|.|||||::|||||.:.|:|::|||.|:.:.||||||||.||:..|  |:..:.|||
  Fly   141 VYVPVREHPDFNFVGRILGPRGMTAKQLEQETGCKIMVRGKGSMRDKKKEDANR--GKPNWEHLS 203

Mouse   129 DELHVLIEVFAPPGEAYSRMSHALEEIKKFLVP--DYNDEIRQEQLRELSYLNGSEESGRGRGIR 191
            |:|||||.|......|..:::.|:.|::|.|||  :..||:::.||.||:.:||:......:.:.
  Fly   204 DDLHVLITVEDTENRATVKLAQAVAEVQKLLVPQAEGEDELKKRQLMELAIINGTYRDTTAKSVA 268

Mouse   192 GRGI-----------------RITPTAPSR--------GRGGAVPPPPPPGRG---VLTPRGTTV 228
            ....                 |:...:.||        |....:..|.....|   :|.||.|
  Fly   269 AFSCVGSASYLYPAVCDEEWRRLVAASDSRLLTSTGLPGLAAQIRAPAAAPLGAPLILNPRMT-- 331

Mouse   229 TRGALPVPPIARGVPTPRARGTAAVPGYRAPPPPAHDAYEEYGYDDGYG---GEYDDQTYEAY-D 289
                         |||.    .|::...:|.|..|.|       ..|:|   ..||...|.|. .
  Fly   332 -------------VPTT----AASILSAQAAPTAAFD-------QTGHGMIFAPYDYANYAALAG 372

Mouse   290 NSYVTPTQSVPEYYDYGHGVNEDAYDSYAPEEWATTRSSLKAPPPRSARGGYREHPYGR 348
            |..:|      ||.|:...:.:.       ...||.                |||||.|
  Fly   373 NPLLT------EYADHSGAIKQQ-------RRLATN----------------REHPYQR 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khdrbs2	NP_573498.1	Qua1	6..57	CDD:292891	18/57 (32%)
		SF1_like-KH	61..180	CDD:239088	56/120 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	181..263		16/109 (15%)
		Sam68-YY	267..321	CDD:293176	11/57 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	321..349		8/28 (29%)
how	NP_001262822.1	STAR_dimer	75..123	CDD:293152	16/46 (35%)
how	NP_001262822.1	SF1_like-KH	139..260	CDD:239088	58/122 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810