DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Idh3b and CG32026

DIOPT Version :9

Sequence 1:	NP_570954.1	Gene:	Idh3b / 170718	MGIID:	2158650	Length:	384	Species:	Mus musculus
Sequence 2:	NP_729420.1	Gene:	CG32026 / 317829	FlyBaseID:	FBgn0052026	Length:	719	Species:	Drosophila melanogaster

Alignment Length:	372	Identity:	137/372 - (36%)
Similarity:	221/372 - (59%)	Gaps:	24/372 - (6%)

- Green bases have known domain annotations that are detailed below.

Mouse    17 ARNSGAWRGLGTSTAHAASQSQAQDVRVEGAFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFKE 81
            |...|...|.|..:..|:.:.:.          :|::||||:|||:..||.::.:||..|:.|:.
  Fly   362 AGGQGQKGGAGGKSGKASGEPRV----------ITLMPGDGIGPEISMAVIKILEAAKTPLIFEP 416

Mouse    82 HHLSEVQNMASEEKL-EQVLSSMKENKVAIIGKIYTPMEYKGE-LASYDMQLRRKLDLFANVVHV 144
            ..::.|.|......: |||:.||...||.:.|.:.||:   |. ..|.::.||:..:|:||:...
  Fly   417 VDVTPVLNSQGMTSVPEQVIESMNRTKVGLKGPLMTPV---GTGFRSLNLTLRQLFNLYANIRPC 478

Mouse   145 KSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESAKGVIECLKIVTRTKSQRIAKFAFDYATKKGR 209
            :||||.:|.:.::|:|.|||.||||||.:||....||::.:|::||..|.|:|::.|.||....|
  Fly   479 RSLPGVETVYGDVDIVTIRENTEGEYSGIEHTLVNGVVQSIKLITRNASLRVAEYTFQYALAMKR 543

Mouse   210 SKVTAVHKANIMKLGDGLFLQCCEEVAELYPK------IKFETMIIDNCCMQLVQNPYQFDVLVM 268
            .|||||.::.:|::.|||||:|..|:|..|..      ||:|...:...|:.:||:|.::|:||:
  Fly   544 KKVTAVAESQVMRMSDGLFLRCVREMAAKYKSKMDQAGIKYEESTMTTVCLNIVQDPKRYDMLVL 608

Mouse   269 PNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAV-GRNIANPTAMLLSATNML 332
            |||||:||.:..|||:||.|:.|..:.....|:||  :.|..|..: |:::|||||:|||:..||
  Fly   609 PNLYGDIISDTCAGLIGGLGLTPSGNVGTNGAIFE--SVHGTAPDIAGKDLANPTALLLSSVMML 671

Mouse   333 RHLNLEYHSSMIADAVKKVIKAGKVRTRDMGGYSTTTDFIKSVIGHL 379
            .::.|..|:..|..||.|.|:...:||.|:||.:..:::..::|.:|
  Fly   672 HYIGLHEHADKIEKAVLKTIRDDNIRTMDLGGKAKCSEYTDALIKNL 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Idh3b	NP_570954.1	Iso_dh	46..379	CDD:351095	131/341 (38%)
CG32026	NP_729420.1	FGF-BP1	<281..361	CDD:284004
CG32026	NP_729420.1	Iso_dh	382..718	CDD:294303	131/350 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0473
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000244
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810