Protein Alignment ADAMTS15 and stl

DIOPT Version :10

• Sequence 1: NP_620686.1
• Gene: ADAMTS15 / 170689
• HGNCID: 16305
• Length: 950
• Species: Homo sapiens
• Sequence 2: NP_001097423.1
• Gene: stl / 37619
• FlyBaseID: FBgn0086408
• Length: 1136
• Species: Drosophila melanogaster
• Alignment Length: 991
• Identity: 230/991 - (23%)
• Similarity: 344/991 - (34%)
• Gaps: 327/991 - (32%)

Human    98 LRRCFYSGDVNAEPDSFAAVSLC--GGLRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLLQRR 160
            |.||||....       ||:.||  |.:||.|...|::.||.|||       .|...|.|:|.:.
  Fly   192 LERCFYRSPA-------AALDLCEPGNVRGVFQQNGSDLVIHPLP-------ARFGTGTHVLYQA 242

Human   161 GV--PGGPSGDPTSRCGVASGWNPAILRALDP------YKPRRAGFGESRSRRRS---------- 207
            .|  .||...:.:||            |...|      ::|....|.|.|.|.|:
  Fly   243 RVDKSGGGYSEASSR------------RTASPLDSQLQFEPDAEEFNEPRRRLRAQSQLQSPLRL 295

Human   208 --------------GRAKRFV---------SIPR--YVETLVVADES----MVKFHGADLE---- 239
                          .|.:|::         .||.  ::||.:..|..    |.|....:.|
  Fly   296 RFQPRHHHPHQHHQQRRRRYIGDAPRSRWSDIPEELFIETAIFVDSDLYAHMQKNFPTNTESKVV 360

Human   240 HYLLTLLATAARLYRHPSILNPINIVVVKVL---------LLRDRDSGPKVTGNAALTLRNFCAW 295
            .:||.::.....||.||::...||.|:.::.         |:|.||        ....|.:||.|
  Fly   361 SFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWDPPGLVRSRD--------VENYLNSFCKW 417

Human   296 QKKLNKVSDKHPEYWDTAILFTRQDLC----GATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSA 356
            |:|||..||..|.::|.|::.|..||.    |......:|||.|..||....||::.|.....|.
  Fly   418 QEKLNPFSDADPLHYDHALVLTGLDLVTYDKGKANSQVVGMATVKGMCTSIYSCTINEAKHFESV 482

Human   357 FTTAHELGHVFNMPHDNVKV-CEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHG 420
            |..|||:||...|.||..:: |:...      |:|||.|  ......||.||...:.|||.....
  Fly   483 FVVAHEIGHNLGMRHDAKEISCDPTM------HIMSPKL--GSGKVTWSKCSRTYLEDFLMDPQA 539

Human   421 DCLLDQPSKPISLPED------LPGASYTLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGQMV 479
            :||.|:.|  .:.|.|      |||..:..:|||.|.||..     :||..|:       ....:
  Fly   540 ECLFDRDS--FAGPWDHTAGGRLPGERFNANQQCMLRFGKN-----FMQASTQ-------SKMEI 590

Human   480 CQTRH-----FPWA-----DGTSCGEGKLCLKGAC----------------------------VE 506
            |:..|     .||.     :||.||....|..|.|                            :.
  Fly   591 CRDLHCRQDGLPWTSHPALEGTECGPNMWCRGGTCEARSSKQGSYSALKSWPPEHIPEATHEKII 655

Human   507 RHNLNK------------HRVDGS---WAKWDPYGPCSRTC-----------GGGVQLARRQCTN 545
            ||..|:            :.:.||   |.:|.....|...|           ..|::...|.|.|
  Fly   656 RHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRSCLN 720

Human   546 PTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGV 610
             .|:.    |.|...::.:||...|         .:...:..|.:  :|.....|....|:.:|.
  Fly   721 -FPSR----CIGRDRRFVTCNTPQC---------HKVPVQTINDF--ATQVCMQARKSDPELTGE 769

Human   611 SPR------DKCKLIC--RANGTGYFYVLAPKVVDGTLC-----SPDSTSVCVQGKCIKAGCDGN 662
            ..:      ..||:.|  |.|||.......|   |||.|     :|:..:.|:.|:|.:..||
  Fly   770 GQQLPSTLDASCKIFCRTRTNGTKSRRWTFP---DGTTCKAKQHNPEDITYCISGRCERFSCD-- 829

Human   663 LGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLA 727
             .|...|.|.     |:..|:..:   .:|..          .:|..:.||:..:     ..|
  Fly   830 -NSTSNFFKM-----DSSFCEARS---VRPTR----------DSSDQESRQQTNR-----QRY-- 868

Human   728 LKNSQGKYLLNGHFVVSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPP 792
            .:..:||...| |:     |.::..:.|.    |.|..:.:
  Fly   869 AERQEGKPQKN-HY-----ENEVAKRPSY----GQGNHINA------------------------ 899

Human   793 RVRYSFYLPKEPREDKSSH----PKDPRGPSVLHNSVLSLSNQVEQPDDRPPARWVAGSWGPCSA 853
                    |..|.:.::.|    |:.||.|.....|:::|........:     |||..  .|.:
  Fly   900 --------PASPYKRRNYHKPYPPEIPRPPPPASASLIALDRSSSSESE-----WVAHP--GCHS 949

Human   854 SCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVET-QACG---EPCPTWELSAWSPCSKSCGRGFQ 914
            :|       ..|.:|      |....:....||: |.|.   :||...:.:| ....::|.|..|
  Fly   950 NC-------MTDSKG------VQGVTSRLTGVESIQLCSYRIQPCERLQTAA-EYAEQTCARYRQ 1000

Human   915 R-RSLKCVGHGGRLLA 929
            : |.|.  |||.::.|
  Fly  1001 KVRGLS--GHGAQISA 1014

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADAMTS15	NP_620686.1	Pep_M12B_propep	24..149	CDD:460254	19/52 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	151..172		6/22 (27%)
		Cysteine switch. /evidence=ECO:0000250	172..179		2/6 (33%)
		ZnMc_ADAMTS_like	218..424	CDD:239801	69/229 (30%)
		ADAMTS_CR_2	438..505	CDD:465496	22/104 (21%)
		TSP1	519..571	CDD:214559	13/62 (21%)
		ADAMTS_CR_3	<616..682	CDD:437068	22/72 (31%)
		ADAMTS_spacer1	684..801	CDD:461796	13/116 (11%)
		Spacer	701..838		21/140 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	798..822		7/27 (26%)
		TSP1_ADAMTS	843..894	CDD:465950	12/54 (22%)
		TSP1_ADAMTS	897..950	CDD:465950	10/34 (29%)
stl	NP_001097423.1	ZnMc_ADAMTS_like	331..543	CDD:239801	69/227 (30%)
		ADAMTS_CR_2	561..625	CDD:465496	21/75 (28%)
		TSP1	683..741	CDD:214559	14/71 (20%)