DRSC/TRiP Functional Genomics Resources

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Protein Alignment ADAMTS15 and loh

DIOPT Version :10

Sequence 1:NP_620686.1 Gene:ADAMTS15 / 170689 HGNCID:16305 Length:950 Species:Homo sapiens
Sequence 2:NP_609406.2 Gene:loh / 34435 FlyBaseID:FBgn0032252 Length:880 Species:Drosophila melanogaster


Alignment Length:644 Identity:151/644 - (23%)
Similarity:231/644 - (35%) Gaps:161/644 - (25%)


- Green bases have known domain annotations that are detailed below.


Human   342 KRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCE-----EVFGKLRANHMMSPTLIQIDRAN 401
            |:..|:.....|.:.:.|..:|......|::..:..|     ::..|.....:.|.|:|.::..|
  Fly    49 KKKISINSYYELANLWHTRKDLSSPKQKPNNKEEYLENETTSKISNKSDEKVLKSSTIISLNATN 113

Human   402 PWSACSAAIITDFLDSGHGDCLLDQPSKPISLPEDL-PGASYTLSQQCELAFGVGSKPCPYMQYC 465
            |.::...::             |:..:.|....:|| ...:...::|......|.|.|.|..:..
  Fly   114 PSTSTFKSV-------------LETTTLPSVTTKDLFESGNVATTRQTPKVEEVFSSPNPPQEAT 165

Human   466 TKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKLCLKGACVERHNLNKHRVDGSWAKWDPYGPCSR 530
            :.  .:.|||.::      :|:.                             .|.||..:..|||
  Fly   166 SS--TSKKAKKKV------YPYP-----------------------------RWDKWSDWSSCSR 193

Human   531 TCGGGVQLARRQCTNPTPANGGKY----CEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYN 591
            :|||||:...|:|.|.......:.    |.|...:|:.||..||...:  ..||..||.|:|...
  Fly   194 SCGGGVKYQVRKCINRNLLTNNQLTSNACVGYFKRYQLCNDVPCDEQS--PDFRASQCSAYNDKE 256

Human   592 HSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTLCSPDS---------TS 647
            ...:|    ..|.|.   |....:|:|.|...|...|..|...|:|||.|...:         .:
  Fly   257 FHGHR----YRWEPY---VKDDAECELNCMPFGMKSFATLNESVIDGTPCGHPAEYFRSQFWERA 314

Human   648 VCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTK---PMHGYNFVVAIPAGASSI 709
            |||.|.|......|.:...........|||  ..|:.|||:||:   |.|.|..|..:|.|||:|
  Fly   315 VCVDGACKAVQASGEIDGLYAHSGSVSCGG--LLCRPVTGIFTRNPLPEHAYIHVTTLPVGASNI 377

Human   710 DIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSLLRYSGTGTA-----VESL 769
            .|.:     |....|.|.|:.|....:.||...||.       .||   |...|..     ::..
  Fly   378 SITE-----LKNSINLLVLRTSNELAIFNGENTVSE-------SGS---YEAVGAVFDYHRIDGA 427

Human   770 QASRPILEPLTVEVLSVGKMTPPR----------------VRYSFYLP--KEPREDKSSHPKDPR 816
            :.|..:.|.:|    |:|   |.|                |:|.:.||  .|..|::.|      
  Fly   428 EDSNGVTEWIT----SIG---PIRDSLQLMVFTKSANNTGVKYEYMLPIVSESEENEMS------ 479

Human   817 GPSVLHNSVLSLSNQVEQPDDRPPAR--------WVAGSWGPCSASCGSGLQKRAVDC------R 867
                |.:|...|.:.:|.......:|        |....:..|:.|||.|.|...:.|      |
  Fly   480 ----LESSDGLLRSGMEDTSSSSSSRAGRKRIFNWKVIGFSSCTKSCGGGTQTPIIRCIRKNPLR 540

Human   868 GSAGQRTVPACDAAHRPVETQ---ACG-EPCPT-WELSAWSPCSKSCGRGFQRRSLKCV 921
            ..:.:|    |..:.:||..:   .|. :|||. |....|..|..|...|.:||.:.||
  Fly   541 YYSQRR----CTHSVKPVLNENLLHCNTQPCPAYWRFDDWGECRCSSSGGLRRREVSCV 595

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADAMTS15NP_620686.1 Pep_M12B_propep 24..149 CDD:460254
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 151..172
Cysteine switch. /evidence=ECO:0000250 172..179
ZnMc_ADAMTS_like 218..424 CDD:239801 13/86 (15%)
ADAMTS_CR_2 438..505 CDD:465496 9/66 (14%)
TSP1 519..571 CDD:214559 20/55 (36%)
ADAMTS_CR_3 <616..682 CDD:437068 20/74 (27%)
ADAMTS_spacer1 684..801 CDD:461796 37/140 (26%)
Spacer 701..838 37/159 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 798..822 5/25 (20%)
TSP1_ADAMTS 843..894 CDD:465950 14/60 (23%)
TSP1_ADAMTS 897..950 CDD:465950 9/25 (36%)
lohNP_609406.2 TSP1 182..238 CDD:214559 20/55 (36%)
ADAMTS_spacer1 349..468 CDD:461796 37/140 (26%)
TSP1_ADAMTS 510..567 CDD:465950 14/60 (23%)
TSP1_ADAMTS 664..715 CDD:465950
TSP1_ADAMTS 720..768 CDD:465950
TSP1_ADAMTS 779..835 CDD:465950
PLAC 847..877 CDD:462560
Blue background indicates that the domain is not in the aligned region.

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