Protein Alignment ADAMTS15 and AdamTS-B

DIOPT Version :10

• Sequence 1: NP_620686.1
• Gene: ADAMTS15 / 170689
• HGNCID: 16305
• Length: 950
• Species: Homo sapiens
• Sequence 2: NP_572247.2
• Gene: AdamTS-B / 31490
• FlyBaseID: FBgn0029791
• Length: 1023
• Species: Drosophila melanogaster
• Alignment Length: 1064
• Identity: 337/1064 - (31%)
• Similarity: 475/1064 - (44%)
• Gaps: 213/1064 - (20%)

Human    17 GGSEP------------EREVVVPIRLDPD-------------INGRRYYWR----GPEDSGDQG 52
            ||..|            |.::|||.|:.||             ::.||:..|    ...|:....
  Fly    28 GGVRPLYGLHSDELVAGEGQLVVPRRVHPDGAFMTHQLEYAHELDHRRHRQRRSLNSEHDTQAAD 92

Human    53 LIFQITAFQEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAEPDSFAAV 117
            |...:....|..:|.|...:.||||....|.....|:..:..::....|.:.|.|..:|.:..|:
  Fly    93 LHLLLPLANETLHLELMAHSYFLAPNLVVERHRRDLRTRSPLTTRHLNCHFHGKVRGQPATNVAI 157

Human   118 SLCGGLRGAFGYRGAEYVISPL------PNASAP--AAQRNS-QGAHLLQRRG--VPGGPSGD-- 169
            |.|.||.|.....|.||.|.|.      |....|  ..||:| :..|.|::|.  ..||.||.
  Fly   158 STCAGLVGHIRTAGNEYFIEPSKEHEPHPVNGHPHVVFQRSSVKPKHSLRKRNKRKRGGKSGSGA 222

Human   170 PTSRCGVASGWNPAILRALDPYKPRR--------------------------------------- 195
            ..|.||..              :|||
  Fly   223 EVSNCGTR--------------EPRRRMETRLEWQARGKVKVQGGRQIRRHHHHHHHHHHKHKYR 273

Human   196 -----------------AGFGESRSRRRSGRAKRFVSIPRYVETLVVADESMVKFHGADLEHYLL 243
                             ..|..........|.:|.:|.||:||||:|||.:|..|| .||..|||
  Fly   274 HHQQKISRVPHTKFKYETQFQTEPDHAEIPRRRRSISSPRHVETLIVADATMSAFH-RDLNGYLL 337

Human   244 TLLATAARLYRHPSILNPINIVVVKVLLLRDRDSGPK--VTGNAALTLRNFCAWQKKLNKVSDKH 306
            |::...:.||:.|||.|.|.||||:::.|.:.:|..:  :|.||...|..||:||.||||.|:|.
  Fly   338 TIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKLNKGSEKD 402

Human   307 PEYWDTAILFTRQDLCGATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPH 371
            |.:.|.|||.||:::| |..|.|||:|:||.||.||:||||.||:|:..:.|..|||||.|.|.|
  Fly   403 PHHHDVAILITRKNIC-ANNCMTLGLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFH 466

Human   372 DNVKV-CEEVFGKLRANHMMSPTL----IQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPI 431
            |..|: |....|.:  .|:|:||.    :|:    .||.||...||.|||.|.|:| ||.|..|:
  Fly   467 DTAKIGCHPRVGPI--VHIMTPTFGADTLQV----CWSNCSRKYITHFLDQGLGEC-LDDPPTPL 524

Human   432 ---SLPEDLPGASYTLSQQCELAFG------VGSKPCPYMQYCTKLWCTGKAKGQMVCQTRHFPW 487
               :...:|||..|....||.|.|.      ||:...|: ::|:.|||  |..|:  |.|...|.
  Fly   525 DEYNYTGELPGMRYNARGQCRLQFNLTTDSEVGACSAPH-EFCSTLWC--KVNGE--CVTHMRPT 584

Human   488 ADGTSCGEGKLCLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGG 552
            |.||.||..|.|..|.||.|..|  ..|:|.|..|..:..|||:|||||...:|:|.||.|||||
  Fly   585 APGTLCGRNKWCQNGKCVRREEL--AAVNGGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGG 647

Human   553 KYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFN--GYNHSTNRLTLAVAWVPKYSGVSPRDK 615
            .:|.|.|.:|:.|...|||  |...|||.:||..|:  .|..:|.:      |:|.:...:|
  Fly   648 VFCIGERKRYKICRKRPCP--AEEPSFRAQQCARFDNVSYQGATYK------WLPFFDKNNP--- 701

Human   616 CKLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNK 680
            |||.|..............|:|||.|:..:.::|:.|.|.|.|||..:.|:.:.|:||||||...
  Fly   702 CKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGD 766

Human   681 SCKKVTGLFTKPM----HGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQG--KYLLNG 739
            .|:.|...:|.|.    ..|..:|.|||.|..|.||:     |....::||:....|  ::.|||
  Fly   767 QCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRE-----LANSPHFLAIATGDGGDRFYLNG 826

Human   740 HFVVSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFYLPKEP 804
            ..::| :..:..:.|:...|...... |::...:||...:::..:..|..:...:.|.|.||
  Fly   827 DSLIS-MPGEFEIAGAESLYDRVDEQ-ETITIPQPIQHSISLYAIVRGNESNAGIFYEFTLP--- 886

Human   805 REDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPPARWVAGSWGPCSASCGSGLQKRAVDCR-- 867
                           .|:   ::...|.:         |...:|..||||||.|:|.|...|:
  Fly   887 ---------------ALN---VTAGRQFQ---------WRLSNWTACSASCGGGVQHREPICQEN 924

Human   868 GSAGQRTVPACDAA--HRPV-ETQACG-EPCPT-WELSAWSPCSKSCGR-GF-----QRRSLKCV 921
            |.|...|:|....|  .||. :::.|| :|||. |....|..|..:|.. ||     :|||:.|:
  Fly   925 GKALGDTLPCWTHAKNKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRSVVCL 989

Human   922 GHGGRLLARDQCNLHRKPQELDFC 945
            .....::|..:|...:||.|::.|
  Fly   990 DEHDVVVADAECGHLQKPAEMEPC 1013

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADAMTS15	NP_620686.1	Pep_M12B_propep	24..149	CDD:460254	37/149 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	151..172		8/25 (32%)
		Cysteine switch. /evidence=ECO:0000250	172..179		3/6 (50%)
		ZnMc_ADAMTS_like	218..424	CDD:239801	101/212 (48%)
		ADAMTS_CR_2	438..505	CDD:465496	27/72 (38%)
		TSP1	519..571	CDD:214559	25/51 (49%)
		ADAMTS_CR_3	<616..682	CDD:437068	24/65 (37%)
		ADAMTS_spacer1	684..801	CDD:461796	28/122 (23%)
		Spacer	701..838		27/138 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	798..822		3/23 (13%)
		TSP1_ADAMTS	843..894	CDD:465950	21/56 (38%)
		TSP1_ADAMTS	897..950	CDD:465950	16/55 (29%)
AdamTS-B	NP_572247.2	Pep_M12B_propep	47..195	CDD:460254	37/147 (25%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	100/212 (47%)
		ADAMTS_CR_2	534..602	CDD:465496	27/72 (38%)
		TSP1	614..666	CDD:214559	25/51 (49%)
		ADAMTS_CR_3	672..768	CDD:437068	34/104 (33%)
		ADAMTS_spacer1	770..886	CDD:461796	28/122 (23%)
		TSP1	901..956	CDD:214559	21/54 (39%)
		TSP1_ADAMTS	959..1020	CDD:465950	16/55 (29%)