DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kirrel and CG34353

DIOPT Version :9

Sequence 1:	XP_011238330.1	Gene:	Kirrel / 170643	MGIID:	1891396	Length:	805	Species:	Mus musculus
Sequence 2:	NP_001287571.1	Gene:	CG34353 / 5740590	FlyBaseID:	FBgn0085382	Length:	581	Species:	Drosophila melanogaster

Alignment Length:	590	Identity:	116/590 - (19%)
Similarity:	217/590 - (36%)	Gaps:	131/590 - (22%)

- Green bases have known domain annotations that are detailed below.

Mouse    32 PHLVVAYLIFVTLALALPGTQTRFSQ-EP----ADQT--VVAGQRAVLPCVLLNY-SGIVQWTKD 88
            ||::...:..|:|.......|:..:: ||    ..:|  .:.|:..||||.:.|. :.:|.| |.
  Fly    58 PHILFLAIAVVSLHFESVSAQSMMTKNEPMFISRSETFKFITGETIVLPCEVANTDTYVVAW-KR 121

Mouse    89 GLALGMGQGLKAW--PRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIP 151
            |:|:.....:|..  ||.|:|..     :||:|.||..:|...|.||......|.....:.:|:|
  Fly   122 GIAILTAGSVKVTPDPRVRLVNG-----FNLQIRDALPTDAGDYICQIATMDPREITHTVEILVP 181

Mouse   152 PEETRIDGGPVILLQAGTPYNLTCRAFNAKPAATIIWFRDGTQQEGAVTSTELLKDGKRETTISQ 216
            |....|..|..:.::.|:...:.|.| ...|...:.|.|          ...:|.:|:.:.....
  Fly   182 PRIHHISTGGHLQVKKGSSVRIECSA-TGNPMPNVTWSR----------KNNILPNGEEKLHSHV 235

Mouse   217 LLIEPTDLDIGRVFTCRSMNEAIPNGKETSIELDVHHPPTVTLSIEPQTVLEGE----RVIFTCQ 277
            |.||..|...|.|:.|.:.|..   |:..|.::.:|...:..:|:|...|..||    .::....
  Fly   236 LSIENVDRHKGGVYICTANNRV---GQPASSQVVLHVLFSPEISVERPVVFSGEGHEATLVCIVH 297

Mouse   278 ATANPEILGYRWAKGGFLIEDAHESRYETN-------------VDYSFFTEPVSCEVYNKVGSTN 329
            ....||::   |.|....::.......||.             .|:..:    ||...|::|...
  Fly   298 GETQPEVI---WFKDTMQLDTTERHIMETRGSRHTLIIRKVHPQDFGNY----SCVAENQLGKAR 355

Mouse   330 VSTLVNVHFAPRIVVYPKPTTTDIGSDVTLTCVWVGNPPL---TLTWTKKDSNMGPRLPGSPPEA 391
            .:  :.:...|.:.|:..|..:.......::.....:.|:   .|::.|..  .|..:.|:..::
  Fly   356 KT--LQLSGKPNVAVFNSPPISQYKDRYNISWAVDSHSPIEEYKLSFRKLP--QGHEVVGNAIDS 416

Mouse   392 NLSAQVLSNSNQLLLKSVTQA--------------DAGTYT-------------CRAIVPRIGVA 429
            :.|:..:|:|:..:..|...|              .:|:|:             ...::|.:.|:
  Fly   417 SSSSSSMSSSSSQMYGSGLHAHRIGSNMGGLSGLSGSGSYSGYGNVIHWGHNDWRNVVLPAVPVS 481

Mouse   430 EREVPLYVNGPPIISSEAVQFAVRG---DGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTV 491
            ..    |..|        :.:.|||   |    :.:..:....:|..|:...|.....|
  Fly   482 HH----YAQG--------MSYMVRGLDPD----QHYEATVQSRNRYGWSDLTNSFVFST------ 524

Mouse   492 ERTNSGSGVLSTLTINNVMEADFQ----THYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIG 552
             .:|.|...|||...:.:.:.:.:    |.|..:|.|             |:.|.:..::.||:.
  Fly   525 -SSNDGPVDLSTFLNHGLSDNEMRDLSVTFYGSSAIN-------------RQKLGLLALSSATLA 575

Mouse   553 AGILV 557
            ..:||
  Fly   576 LSLLV 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kirrel	XP_011238330.1	Ig	54..148	CDD:386229	29/103 (28%)
		Ig2_KIRREL3-like	170..251	CDD:143236	17/80 (21%)
		Ig	255..336	CDD:386229	16/97 (16%)
		Ig_3	340..421	CDD:372822	15/110 (14%)
		Ig5_KIRREL3	439..536	CDD:143306	18/103 (17%)
CG34353	NP_001287571.1	IG_like	100..180	CDD:214653	26/85 (31%)
		Ig	103..177	CDD:143165	25/79 (32%)
		IG_like	191..269	CDD:214653	18/91 (20%)
		IGc2	198..258	CDD:197706	16/73 (22%)
		I-set	273..360	CDD:254352	16/95 (17%)
		Ig	290..359	CDD:143165	11/77 (14%)
		FN3	<466..524	CDD:238020	11/73 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900