DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kirrel and DIP-gamma

DIOPT Version :9

Sequence 1:	XP_011238330.1	Gene:	Kirrel / 170643	MGIID:	1891396	Length:	805	Species:	Mus musculus
Sequence 2:	NP_651649.1	Gene:	DIP-gamma / 43417	FlyBaseID:	FBgn0039617	Length:	413	Species:	Drosophila melanogaster

Alignment Length:	428	Identity:	92/428 - (21%)
Similarity:	151/428 - (35%)	Gaps:	112/428 - (26%)

- Green bases have known domain annotations that are detailed below.

Mouse    40 IFVTLALAL---PGTQTRFSQEPADQ--------------TVVAGQRAVLPCVLLNY-SGIVQWT 86
            :||.|.:|.   .|:......|.:.|              |..||:.|:|.|.:.|. ...|.|.
  Fly     9 LFVILIMATKCGSGSTQNQHHESSSQLDPDPEFIGFINNVTYPAGREAILACSVRNLGKNKVGWL 73

Mouse    87 K--DGLALGMGQGLKAWPRYRV-VGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTV 148
            :  |...|.: ||.......|: |...|...:.|:|:....||...|.||...:.::.:...:.|
  Fly    74 RASDQTVLAL-QGRVVTHNARISVMHQDMHTWKLKISKLRESDRGCYMCQINTSPMKKQVGCIDV 137

Mouse   149 LIPPEETRIDGGPVILLQAGTPYNLTCRAFNAKPAATIIWFR-DG----TQQEGAVTSTELLK-D 207
            .:||:....:....:.:|.|....|||:| ...|...:.|.| ||    .::.|   |.||:| :
  Fly   138 QVPPDIINEESSADLAVQEGEDATLTCKA-TGNPQPRVTWRREDGEMILIRKPG---SRELMKVE 198

Mouse   208 GKRETTISQLLIEPTDLDIGRVFTCRSMNEAIPNGKETSIELDVHHPPTVTLSIEPQTVLE---G 269
            ....:::..|.:|...:.   .:.|.:.|: :|......:.|.|...|.|.   .|..:|.   |
  Fly   199 SYNGSSLRLLRLERRQMG---AYLCIASND-VPPAVSKRVSLSVQFAPMVR---APSQLLGTPLG 256

Mouse   270 ERVIFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVYNKVGSTNVSTLV 334
            ..|...||..|:|..:.| |.||                          ....|...|.:.::|.
  Fly   257 SDVQLECQVEASPSPVSY-WLKG--------------------------ARTSNGFASVSTASLE 294

Mouse   335 NVHFAPRIVV-YPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMGPRLPGSPPEANLSAQVL 398
            :....|.::: .||...|:                      ::|...|..|
  Fly   295 SGSPGPEMLLDGPKYGITE----------------------RRDGYRGVML-------------- 323

Mouse   399 SNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLY 436
                 |:::|.:.:|.|||.| .....:|.||..:.||
  Fly   324 -----LVVRSFSPSDVGTYHC-VSTNSLGRAEGTLRLY 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kirrel	XP_011238330.1	Ig	54..148	CDD:386229	25/111 (23%)
		Ig2_KIRREL3-like	170..251	CDD:143236	20/86 (23%)
		Ig	255..336	CDD:386229	17/83 (20%)
		Ig_3	340..421	CDD:372822	14/81 (17%)
		Ig5_KIRREL3	439..536	CDD:143306
DIP-gamma	NP_651649.1	IG_like	47..139	CDD:214653	24/92 (26%)
		Ig	47..129	CDD:299845	23/82 (28%)
		Ig	140..238	CDD:299845	24/105 (23%)
		IG_like	247..355	CDD:214653	32/176 (18%)
		Ig	256..351	CDD:299845	30/163 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900