DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kirrel and bdl

DIOPT Version :9

Sequence 1:	XP_011238330.1	Gene:	Kirrel / 170643	MGIID:	1891396	Length:	805	Species:	Mus musculus
Sequence 2:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster

Alignment Length:	698	Identity:	145/698 - (20%)
Similarity:	225/698 - (32%)	Gaps:	192/698 - (27%)

- Green bases have known domain annotations that are detailed below.

Mouse   178 FNAKPAATIIWFRDGT------QQEGAVTSTELLKDGKRETTISQLLIEPTDLDIGRV------- 229
            |:|.....:.|.:|..      :||   |||..|.:|:..      |:| ...:.||.
  Fly    61 FDAPIPYLVHWTKDNKKIFTWYEQE---TSTSELFNGRLH------LVE-NHPEFGRASVNLTAI 115

Mouse   230 -------FTCRSMNEAIPN------GKETSIELDVHHPPTVTLSIEPQTVLEGERVIFTCQATAN 281
                   :.|:   .:.||      ...|:..|.|.....:.:....||:.||:...|.| ...:
  Fly   116 RESDQGWYHCQ---VSFPNRSPSVRNNGTAYHLAVQGGSLIRIPPVNQTIREGQTAFFHC-VMKH 176

Mouse   282 PEILGYRWAKGGFLIEDAHE--SRYETNVDYSFFTEPV--------SCEVYNKVGSTNVS-TLVN 335
            ||.....|.|.|.|:::..:  .|:....|.|...:|.        .|:|.|..|....: ..:|
  Fly   177 PENSQASWYKDGVLLQEVQDLVRRFYMGPDGSLSIDPTMMSDLGEYECKVRNSDGELQTAKAFLN 241

Mouse   336 VHFAPRIVVYPKPTTTDIGSDVTLTCVWVGNPPL-TLTWTKK----DSNMGPRLPGSPPEANLSA 395
            :.:..:::..|.......|....|.|.:..|||| .|.|.|.    ||.   .:||...:.|
  Fly   242 IQYKAKVIYAPPEVFLPYGQPAVLDCHFRANPPLKNLRWEKDGLLFDSY---NVPGVFYKMN--- 300

Mouse   396 QVLSNSNQLLLKSVTQADAGTYTCRAI--------VPRIGVAEREVPLYVNGPPI--ISSEAVQF 450
                  ..|....|.:..||:|||...        .|.|.|       .|..|||  ::.:|:..
  Fly   301 ------GSLFFAKVDENHAGSYTCTPYNDLGTDGPSPVISV-------IVLRPPIFSVTPKAIYI 352

Mouse   451 AVRGDGGKVECFI----GSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVME 511
            ...|:..::.|..    |:..|  .|.|..|:.       :....:|.:...|   .|||..::|
  Fly   353 QKLGEAAELPCEAIDRDGNNRP--SIIWGRKDG-------QPLPADRFSLSGG---NLTITGLVE 405

Mouse   512 ADFQTHYNCTAWNSFGPGTAIIQLEEREV---LPVGIIAGATIGAGILVV-----FSFAALVFFL 568
            .| :..|.|:|.|.....||..:|....:   .|..:.|.:|  ...:.:     :....|.:.:
  Fly   406 GD-RGIYECSATNEAATITAEAELMIENIAPRAPYNLTANST--ETCITIRWQPGYLRPNLEYTV 467

Mouse   569 YRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASISTATRVMKAIYSSFKDDVDLKQDL 633
            :.|...:.:..|||.||.||.....:.|....:.|           .|......:.|.:..|| .
  Fly   468 WYRLMEAPEWRTLRVLDKKVMEATVQHLQPGKEYE-----------FMVLSQDKYGDGMFSKQ-F 520

Mouse   634 RCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPTRFDGRPSSRLSHSSGYAQL 698
            |..|:                                     |.|.|.|...:.:|.|..|..
  Fly   521 RFQTL-------------------------------------PSPIRADDFDAQQLQHDLGQV-- 546

Mouse   699 NTYSRAPASDYGTEPTPSGPSAPGGTDTTSQ-----LSYENYEKFNSHPFPGAAGYPTYRLGYPQ 758
                .|||...|         ||......|.     |.:|       ||..|..|...|.:.:.:
  Fly   547 ----TAPAGGLG---------APWNLTAISNQQGWLLHWE-------HPVQGLEGLRLYAVRWWK 591

Mouse   759 APPSGL--ERTPYEAYDPIGKYATATRFSYTSQHSDYGQRFQQRMQTH 804
            .|...|  ....::.|..:......|.|..  |....|...||.:.:|
  Fly   592 EPEHFLIGHAETFDNYYQLRHLKEDTLFKV--QVLAVGTETQQSVPSH 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kirrel	XP_011238330.1	Ig	54..148	CDD:386229
		Ig2_KIRREL3-like	170..251	CDD:143236	20/98 (20%)
		Ig	255..336	CDD:386229	20/91 (22%)
		Ig_3	340..421	CDD:372822	23/85 (27%)
		Ig5_KIRREL3	439..536	CDD:143306	24/102 (24%)
bdl	NP_608822.1	IG_like	42..128	CDD:214653	16/79 (20%)
		Ig	43..131	CDD:299845	16/82 (20%)
		I-set	153..242	CDD:254352	20/89 (22%)
		Ig	157..242	CDD:299845	20/85 (24%)
		Ig_2	252..337	CDD:290606	26/103 (25%)
		IG_like	260..327	CDD:214653	22/78 (28%)
		I-set	341..428	CDD:254352	23/99 (23%)
		IGc2	356..419	CDD:197706	18/75 (24%)
		FN3	435..524	CDD:238020	19/102 (19%)
		FN3	554..636	CDD:238020	20/99 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900