DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kirrel and fred

DIOPT Version :9

Sequence 1:	XP_011238330.1	Gene:	Kirrel / 170643	MGIID:	1891396	Length:	805	Species:	Mus musculus
Sequence 2:	NP_608812.3	Gene:	fred / 33613	FlyBaseID:	FBgn0051774	Length:	1447	Species:	Drosophila melanogaster

Alignment Length:	827	Identity:	181/827 - (21%)
Similarity:	303/827 - (36%)	Gaps:	206/827 - (24%)

- Green bases have known domain annotations that are detailed below.

Mouse    84 QWT-----KDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELS-DDASYEC----QATEAA 138
            :||     .:.:|:|   .::....||:......|.|:|:|.:...: |:..:||    :.|.|.
  Fly    54 RWTCCPTLFENVAIG---DVQLNSNYRLDFRPSRGIYDLQIKNTSYNRDNGRFECRIKAKGTGAD 115

Mouse   139 LRSRRAKLTVLIPPEETRIDGGPVILLQAGTPYNLTCRAFNAKPAATIIWFRDGTQQEGAVTSTE 203
            :......||||..|....:..|.:.:.....|..|||.:....|...|.|:|:|:.   ....:.
  Fly   116 VHQEFYNLTVLTAPHPPMVTPGNLAVATEEKPLELTCSSIGGSPDPMITWYREGST---VPLQSY 177

Mouse   204 LLKDG-KRETTISQLLIEPTDLDIGRVFTCRSMNEAIPNGK--ETSIELDVHHPPTVTLSIEPQT 265
            .||.| |...|.:.|.|.|...|.|..:.|...|.|:|.|.  |||:.|:|::.|.|  .:.||.
  Fly   178 ALKGGSKNHYTNATLQIVPRRADDGAKYKCVVWNRAMPEGHMLETSVTLNVNYYPRV--EVGPQN 240

Mouse   266 VLEGER---VIFTCQATANPEILGYRWAKGG-----------FLIEDAHESRYETNVDYSFFTEP 316
            .|:.||   ....|:..|.|.:...||::.|           :.:...|..:|
  Fly   241 PLKVERDHVAKLDCRVDAKPMVSNVRWSRNGQYVSATPTHTIYRVNRHHAGKY------------ 293

Mouse   317 VSCEVYNKVGSTNVSTLV-NVHFAPRIVVYPKPTTTDIGSDVTLTCVWVGNP-PLTLTWTKKDSN 379
             :|...|.:|.|....:| :|.:.|.:.:..|....:.|..|.:.|....|| |:.:.|.|:.:
  Fly   294 -TCSADNGLGKTGEKDIVLDVLYPPIVFIESKTHEAEEGETVLIRCNVTANPSPINVEWLKEGA- 356

Mouse   380 MGPRLPGSPPEANLSAQVLSNSNQLLLKSVTQADAGTYTCRAI-------VPRI-GVAEREVPLY 436
                     |:...:.::|:      |.||....||.|.||::       ..|: ||....|.|.
  Fly   357 ---------PDFRYTGELLT------LGSVRAEHAGNYICRSVNIMQPFSSKRVEGVGNSTVALL 406

Mouse   437 VNGPP----IISSEAVQFAVRGDGGKVECFIGSTPPP----DRIAWAWKENFLEVGTLER----- 488
            |...|    |..::.|...  |:|..:.|   |..||    .:..| :::...::|..::
  Fly   407 VRHRPGQAYITPNKPVVHV--GNGVTLTC---SANPPGWPVPQYRW-FRDMDGDIGNTQKILAQG 465

Mouse   489 --YTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPG---TAIIQ----------LEER 538
              |::.:.:.||                :..|:|.|.|..|.|   |.|::          |::.
  Fly   466 PQYSIPKAHLGS----------------EGKYHCHAVNELGIGKIATIILEVHQPPQFLAKLQQH 514

Mouse   539 EVLPVGIIAGATIGAGILVVFSFAALVFFLYRRRKGSRKDVTLRKL-DIKVETVNREPLTMHSDR 602
            ....||.:..|       |..|.........|..|...:.:..||: ||:         |..:|.
  Fly   515 MTRRVGDVDYA-------VTCSAKGKPTPQIRWIKDGTEILPTRKMFDIR---------TTPTDA 563

Mouse   603 EDDTASISTATRVM--------------KAIYSS-FKDDVDLKQDLRCDTIDTREEYEMKDP-TN 651
            .....::.:..|..              :.:|:. :::||:...    .::..|.|:|   | ..
  Fly   564 GGGVVAVQSILRFRGKARPNGNQLLPNDRGLYTCLYENDVNSAN----SSMHLRIEHE---PIVI 621

Mouse   652 GYYNVRAHEDRPSSRAVL-------------YADYRAPGPTRFDG--RPSSRLSHSSGYAQLNTY 701
            ..||..|::.|.|:..|.             |.:..:|.....||  ..|:|:.::..|..:...
  Fly   622 HQYNKVAYDLRESAEVVCRVQAYPKPEFQWQYGNNPSPLTMSSDGHYEISTRMENNDVYTSILRI 686

Mouse   702 SRAPASDYG------TEPTPSGPSAP------GGTDTTSQLSY----ENYEKFNSHP-FPGAAGY 749
            :....||||      ..|..| ..||      |..:..:.|..    .||...|..| |.|....
  Fly   687 AHLQHSDYGEYICRAVNPLDS-IRAPIRLQPKGSPEKPTNLKILEVGHNYAVLNWTPGFNGGFMS 750

Mouse   750 PTYRLGYPQAPPSGLERTPYE--AYDPIGK-YATATRFSYTSQHSDY 793
            ..|.:.|.:.      .||.|  ..|..|. |..:.:.|.:|.:|::
  Fly   751 TKYLVSYRRV------ATPREQTLSDCSGNGYIPSYQISSSSSNSNH 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kirrel	XP_011238330.1	Ig	54..148	CDD:386229	16/73 (22%)
		Ig2_KIRREL3-like	170..251	CDD:143236	28/83 (34%)
		Ig	255..336	CDD:386229	20/95 (21%)
		Ig_3	340..421	CDD:372822	19/81 (23%)
		Ig5_KIRREL3	439..536	CDD:143306	22/124 (18%)
fred	NP_608812.3	Ig	29..126	CDD:299845	17/74 (23%)
		IG_like	141..228	CDD:214653	28/89 (31%)
		Ig	147..228	CDD:299845	28/83 (34%)
		I-set	232..313	CDD:254352	20/95 (21%)
		IGc2	250..302	CDD:197706	10/64 (16%)
		IG_like	323..385	CDD:214653	19/77 (25%)
		IGc2	330..385	CDD:197706	18/70 (26%)
		Ig_2	416..501	CDD:290606	21/106 (20%)
		IG_like	418..501	CDD:214653	20/104 (19%)
		I-set	505..612	CDD:254352	18/126 (14%)
		Ig	526..611	CDD:143165	14/97 (14%)
		IG_like	633..715	CDD:214653	17/82 (21%)
		Ig	635..713	CDD:143165	16/78 (21%)
		FN3	720..838	CDD:238020	18/78 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838623
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840