DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kirrel and Fas2

DIOPT Version :9

Sequence 1:	XP_011238330.1	Gene:	Kirrel / 170643	MGIID:	1891396	Length:	805	Species:	Mus musculus
Sequence 2:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster

Alignment Length:	791	Identity:	161/791 - (20%)
Similarity:	253/791 - (31%)	Gaps:	275/791 - (34%)

- Green bases have known domain annotations that are detailed below.

Mouse   132 CQATEAALRSRRAKLTVLIPPEETRIDGGPVILLQAGTPYNLTCRAFNAKPA--ATIIWFRDGTQ 194
            |..:...|...::.:..:.|.:|  :...||     |.|..||||....:|:  |.:.|
  Fly    18 CSCSLIELTRAQSPILEIYPKQE--VQRKPV-----GKPLILTCRPTVPEPSLVADLQW------ 69

Mouse   195 QEGAVTSTELLKDGKRETTISQLLIEPTDLDIGRVFTCRSMNEAIPNGKETSIELDVHHPPTVT- 258
                       ||.:..|.:.:                       |||:        :.||..|
  Fly    70 -----------KDNRNNTILPK-----------------------PNGR--------NQPPMYTE 92

Mouse   259 --------LSIEPQTVLEGERVIFTCQAT-ANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFT 314
                    |.|...:|..|.:  :.|.|: ||.|||    .||
  Fly    93 TLPGESLALMITSLSVEMGGK--YYCTASYANTEIL----EKG---------------------- 129

Mouse   315 EPVSCEVYNKVGSTNVSTLVNVHFAPRIVVYPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSN 379
              |:.:.|..:..||.               |:.....:|.|..:.|....:|..|:.|.:.
  Fly   130 --VTIKTYVAITWTNA---------------PENQYPTLGQDYVVMCEVKADPNPTIDWLRN--- 174

Mouse   380 MGPRLPGSPPEANLSAQVLSNSNQLLLKSVTQADAGTYTCRAIVPRIG-VAER--EVPLYVNGPP 441
                  |.|........|: .:|.||:::|.::|.|.|||||.|...| :.||  .|.:::. |.
  Fly   175 ------GDPIRTTNDKYVV-QTNGLLIRNVQESDEGIYTCRAAVIETGELLERTIRVEVFIQ-PE 231

Mouse   442 IISSEAVQFAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTI 506
            |||......||.|......|.....|.|: |:|......|.|.|.:|:.|   |..:|:   :||
  Fly   232 IISLPTNLEAVEGKPFAANCTARGKPVPE-ISWIRDATQLNVATADRFQV---NPQTGL---VTI 289

Mouse   507 NNVMEADFQTHYNCTAWNSFG---PGTAIIQLEEREVLPVGIIAGATIGAGILVVFSFA------ 562
            ::|.:.|:.| |.|.|.|..|   ..|.:..|...::..:..:.||....  :.:...|
  Fly   290 SSVSQDDYGT-YTCLAKNRAGVVDQKTKLNVLVRPQIYELYNVTGARTKE--IAITCRAKGRPAP 351

Mouse   563 ALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTAS--ISTATRVMKAIYS---- 621
            |:.|    ||.|::::.|..:.|.....: .|| ....:|.:.|.:  ||.|.|....:|.
  Fly   352 AITF----RRWGTQEEYTNGQQDDDPRII-LEP-NFDEERGESTGTLRISNAERSDDGLYQCIAR 410

Mouse   622 --------------SFKDDV-------------DLKQDLRC--------------------DTID 639
                          .|..|.             ..|.:|.|                    |..|
  Fly   411 NKGADAYKTGHITVEFAPDFSHMKELPPVFSWEQRKANLSCLAMGIPNATIEWHWNGRKIKDLYD 475

Mouse   640 T---------REEYEMKDPTNGYY--------NVR-----------------AHEDRPSSRAVLY 670
            |         |.:..:...|..||        |:.                 ..|.:||......
  Fly   476 TNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQLKEARVPDFVSEAKPSQLTATT 540

Mouse   671 ADYRAPGPTRFDGRPSSRLSHSSGYAQ-LN-TYSRAPASDYGTEPTPSGPSAPGGTDTTSQLSYE 733
            ..:...||:...|.|.  |::|..|.: || .:|.|    |....:|..|....|....::.|:
  Fly   541 MTFDIRGPSTELGLPI--LAYSVQYKEALNPDWSTA----YNRSWSPDSPYIVEGLRPQTEYSF- 598

Mouse   734 NYEKFNSHPFPGAAGYPTYRLGYPQAPP-SGLERTPYEAYDPIGKYATATRFSYTSQH------- 790
               :|.:.   ...|...:.:...|:.| ......|...::|:             ||
  Fly   599 ---RFAAR---NQVGLGNWGVNQQQSTPRRSAPEEPKPLHNPV-------------QHDKEEPVV 644

Mouse   791 -SDYGQRFQQR 800
             |.|...|:.|
  Fly   645 VSPYSDHFELR 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kirrel	XP_011238330.1	Ig	54..148	CDD:386229	2/15 (13%)
		Ig2_KIRREL3-like	170..251	CDD:143236	14/82 (17%)
		Ig	255..336	CDD:386229	19/90 (21%)
		Ig_3	340..421	CDD:372822	19/80 (24%)
		Ig5_KIRREL3	439..536	CDD:143306	30/99 (30%)
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	35/178 (20%)
		IG_like	144..226	CDD:214653	26/91 (29%)
		IGc2	152..209	CDD:197706	18/66 (27%)
		I-set	230..319	CDD:254352	30/96 (31%)
		IGc2	243..309	CDD:197706	22/73 (30%)
		IG_like	330..424	CDD:214653	19/101 (19%)
		IGc2	339..412	CDD:197706	17/78 (22%)
		Ig	447..518	CDD:143165	10/70 (14%)
		fn3	534..611	CDD:278470	19/89 (21%)
		FN3	640..735	CDD:238020	4/16 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900